分子病態治療研究センター 心血管・遺伝学研究部
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  2. 奥田 浩

奥田 浩

オクダ ヒロシ  (Hiroshi Okuda)

基本情報

所属
自治医科大学 医学部数学 教授
J-GLOBAL ID
201401009209723250
researchmap会員ID
B000238167
外部リンク

研究キーワード

 18

研究分野

 5

経歴

 15
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受賞

 1

論文

 55
  • Sho Sugiyama, Yong Hwa Chong, Masayuki Shito, Manami Kasuga, Tsuyoshi Kawakami, Chihiro Udagawa, Hiroshi Aoki, Makoto Bonkobara, Shuichi Tsuchida, Atsushi Sakamoto, Hiroshi Okuda, Atsushi Nagai, Toshinori Omi
    LEGAL MEDICINE 15(6) 303-309 2013年11月  査読有り責任著者
    To develop DNA markers for forensic analysis, we examined the hypervariable region 1 (HVR1) sequences of 447 pure-bred domestic dogs (Canis lupus familiaris) that had been bred and raised in Japan. HVR1 is a 660-bp stretch of mitochondrial (mt) DNA. Among the 447 HVR1 sequences examined, we identified 58 haplotypes from 47 single nucleotide polymorphisms (SNPs) and two insertion-deletion (InDel) polymorphisms. The haplotype diversity inferred from inter-breed analysis (N = 154, 88 breeds) was 0.929 +/- 0.011. Intra-breed analysis showed that the haplotype diversity of Golden Retrievers (N = 53), Labrador Retrievers (N = 67), Miniature Dachshunds (N = 61), Toy Poodles (N = 62), and Welsh Corgis (N = 50) was 0.624 +/- 0.052, 0.722 +/- 0.029, 0.922 +/- 0.010, 0.877 +/- 0.020, and 0.443 +/- 0.084, respectively. The results of this genotype analysis were used to construct a dataset consisting of dog mtDNA HVR1 sequences for use in forensic applications in Japan. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
  • 杉山 将, 鄭 英和, 市東 正幸, 河上 剛, 宇田川 智野, 近江 俊徳, 盆子原 誠, 奥田 浩, 土田 修一
    DNA多型 19 56-58 2011年  責任著者
  • Maki Kumada, Munkhtulga Lkhagvasuren, Nanami Utsumi, Toshinori Omi, Takaya Gotoh, Toyomi Kamesaki, Hiroshi Okuda, Eiji Kajii, Sadahiko Iwamoto
    COMMUNITY GENETICS 11(3) 150-159 2008年  査読有り責任著者
    Objective: The aim of the study was to investigate genetic heterogeneity among local Japanese populations. Methods: We performed a single nucleotide polymorphism (SNP) study of four demographically distinct local populations (population 1: a large city; population 2: isolated islands; populations 3 and 4: rural areas). Seventy SNPs in a region spanning 5 Mb of chromosome 17 known to be a candidate region for essential hypertension were genotyped and linkage disequilibrium analyses were performed. Results: Statistical analyses of SNP allele frequencies and haplotype distribution showed significant divergence among the populations, mostly between population 2 and the other populations. Pairwise D' declined with increasing population size, and smaller populations retained a high linkage disequilibrium. Conclusion: Population 2 is likely to have a different ancestry from the majority of the Japanese population, whereas the heterogeneity among the other populations may result from differences in population size or geographic background. Copyright (C) 2008 S. Karger AG, Basel.
  • Omi T, Kumada M, Kamesaki T, Okuda H, Munkhtulga L, Yanagisawa Y, Utsumi N, Gotoh T,Hata A, Soma M, Umemura S, Ogihara T, Takahashi N, Tabara Y,Shimada K, Mano H, Kajii E,Miki T,Iwamoto S.
    Eur J Hum Genet. 14(12) 1295-1305 2006年  査読有り責任著者
  • 高橋 順子, 近江 俊徳, 山下 順香, 田中 光信, 平山 文也, 亀崎 豊実, 奥田 浩, 岩本 禎彦, 梶井 英治, 谷 慶彦, 柴田 弘俊
    血液事業 28(2) 329-329 2005年8月  
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MISC

 3
  • M Kumada, S Iwamoto, T Kamesaki, H Okuda, E Kajii
    GENE 299(1-2) 165-172 2002年10月  
    The mouse genomic sequence of the region containing the gene Rhced, the orthologue to the human gene RH30, was determined to elucidate the structure of Rhced and its flanking regions and to compare these with the corresponding human genomic region. Two genes, Smpl and AK003528 (an orthologue of FLJ10747), flank Rhced. Neither sequences homologous to the characteristic nucleotide elements flanking the RHD gene in humans (rhesus boxes) nor an additional Rh gene were found within the mouse region sequenced. This result and that of a previous report demonstrate that this chromosomal region of the mouse comprises five genes (FLJI0747-RHCE-SMP1-NPD014-P29) that exhibit syntenic homology with the corresponding human region, which suggests that the RHD gene and rhesus boxes were inserted later. Evaluations of tissue distribution and subcellular localization of these genes indicate that the SMPI orthologue has a ubiquitous tissue distribution and cytoplasmic localization, whereas AK003528 is expressed slightly higher in testis with a strong subcellular localization in the nucleus. Despite the steady improvements in the draft sequence of the human genome, this study demonstrates the continuing benefits of comparative genetic analyses in increasing our understanding of human genomic structure. (C) 2002 Elsevier Science B.V. All rights reserved.
  • 岩本 禎彦, 亀崎 豊実, 熊田 真樹, 奥田 浩, 袴田 陽二, 小林 英司, 梶井 英治
    日本輸血学会雑誌 47(2) 200-200 2001年4月  
  • 亀崎豊実, 岩本禎彦, 近江俊徳, 奥田浩, 田中光信, 高橋順子, 瀬尾たい子, 谷慶彦, 梶井英治
    日本法医学雑誌 54(2) 2000年  

書籍等出版物

 7
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講演・口頭発表等

 84
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担当経験のある科目(授業)

 8
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共同研究・競争的資金等の研究課題

 11
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