大口昭英

オオクチアキヒデ (Akihide Ohkuchi)

基本情報

所属: 自治医科大学附属病院総合周産期母子医療センター母体・胎児集中治療管理部教授

学位: 医学博士(自治医科大学)

研究者番号: 10306136
J-GLOBAL ID: 200901062593291379
researchmap会員ID: 1000273353

研究キーワード

研究分野

経歴

学歴

1981年4月 - 1987年3月

自治医科大学（JMU）医学部医学科
- 1987年

自治医科大学

委員歴

2023年4月 - 現在

日本産科婦人科学会ガイドライン産科編2026評価委員会
2021年11月 - 現在

日本産科婦人科学会産科婦人科用語集・用語解説集改訂第5版編集委員
2013年 - 現在

関東連合産科婦人科学会地域活性化委員会委員
2006年 - 現在

日本産科婦人科学会 Associate Editor for the Journal of Obstetrics and Gynaecology Research
2021年10月 - 2023年9月

日本妊娠高血圧学会学術委員会委員長

もっとみる

受賞

2020年10月

第11回 Hypertension Research Award 優秀賞日本高血圧学会
2012年

優秀ポスター賞国際妊娠高血圧学会

大口昭英
2012年

優秀論文賞自治医科大学

大口昭英
2010年

優秀論文賞自治医科大学

大口昭英

論文

260

Markedly higher sFlt-1/PlGF ratio in a woman with acute fatty liver of pregnancy compared with HELLP syndrome.

Suzuki H, Nagayama S, Hirashima C, Takahashi K, Takahashi H, Ogoyama M, Nagayama M, Shirasuna K, Matsubara S, Ohkuchi A

The journal of obstetrics and gynaecology research 45(1) 96-103 2018年8月査読有り
Aggregation of Human Trophoblast Cells into Three-Dimensional Culture System Enhances Anti-Inflammatory Characteristics through Cytoskeleton Regulation

Seno Kotomi, Munakata Yasuhisa, Sano Michiya, Kawahara-Miki Ryouka, Takahashi Hironori, Ohkuchi Akihide, Iwata Hisataka, Kuwayama Takehito, Shirasuna Koumei

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19(8) 2018年8月査読有り
Magnetic resonance imaging of degeneration of uterine adenomyosis during pregnancy and post-partum period

Hiroto Hirashima, Akihide Ohkuchi, Rie Usui, Shigeyoshi Kijima, Shigeki Matsubara

Journal of Obstetrics and Gynaecology Research 44(6) 1169-1173 2018年6月1日査読有り
Oxygen concentration modulates cellular senescence and autophagy in human trophoblast cells

Kotomi Seno, Nao Tanikawa, Hironori Takahashi, Akihide Ohkuchi, Hirotada Suzuki, Shigeki Matsubara, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna

American Journal of Reproductive Immunology 79(6) 2018年6月1日査読有り
Re: Peripartum hysterectomy: an economic analysis of direct healthcare costs using routinely collected data: Some concerns from obstetricians' viewpoint

Shigeki Matsubara, Hironori Takahashi, Daisuke Matsubara, Akihide Ohkuchi

BJOG: An International Journal of Obstetrics and Gynaecology 125(7) 905-906 2018年6月1日査読有り
Intrauterine ritodrine exposure and childhood asthma: Is ritodrine a real culprit?

Shigeki Matsubara, Hironori Takahashi, Akihide Ohkuchi, Hideki Kumagai, Shizukiyo Ishikawa

Pediatric Allergy and Immunology 29(3) 332-333 2018年5月1日査読有り
MicroRNA.

Takizawa T, Ohkuchi A, Matsubara S, Takeshita T, Saito S

In: Saito, Shigeru (ed) Preeclampsia: Basic, Genomic, and Clinical (Series Title: Comprehensive Gynecology and Obstetrics) 209-224 2018年4月査読有り
Increased serum levels of sFlt-1/PlGF ratio in preeclamptic women with onset at <32 weeks compared with ≥32 weeks

Hirotada Suzuki, Chikako Hirashima, Shiho Nagayama, Kayo Takahashi, Tatsuo Yamamoto, Shigeki Matsubara, Akihide Ohkuchi

Pregnancy Hypertension 12 96-103 2018年4月1日査読有り
Matsubara–Takahashi cervix-holding technique for massive postpartum hemorrhage in patients with placenta previa with or without placenta accreta spectrum disorders

Hironori Takahashi, Akihide Ohkuchi, Rie Usui, Hirotada Suzuki, Yosuke Baba, Shigeki Matsubara

International Journal of Gynecology and Obstetrics 140(3) 357-364 2018年3月1日査読有り
Pregnancy outcomes in Japanese pregnant women with either chronic hypertension or white coat hypertension (JP-WCH): protocol for a prospective multicenter cohort study

Hiroshima Chikako, Takahashi Kayo, Saito Shigeru, Seki Hiroyuki, Watanebe Kazushi, Naruse Katsuhiko, Makino Shintaro, Metoki Hirohito, Matsubara Shigeki, Ichihara Atsuhiro, Ohkuchi Akihide

HYPERTENSION RESEARCH IN PREGNANCY 6(1) 7-10 2018年3月査読有り
Absent Ductus Venosus Associated with Partial Liver Defect.

Horie K, Takahashi H, Matsubara D, Kataoka K, Furukawa R, Baba Y, Ohkuchi A, Matsubara S

Case reports in obstetrics and gynecology 2018 6591025 2018年査読有り
Galectin-1 as a novel risk factor for both gestational hypertension and preeclampsia, specifially its expression at a low level in the second trimester and a high level after onset

Chikako Hirashima, Akihide Ohkuchi, Shiho Nagayama, Hirotada Suzuki, Kayo Takahashi, Manabu Ogoyama, Hironori Takahashi, Koumei Shirasuna, Shigeki Matsubara

Hypertension Research 41(1) 45-52 2018年査読有り
Increase of maternal peripheral blood NK cells from follicular phase to luteal phase

Yoichi Ishida, Akihide Ohkuchi, Tatsuya Suzuki, Toshihiro Takizawa, Hironori Takahashi, Shigeki Matsubara

JOURNAL OF REPRODUCTIVE IMMUNOLOGY 124 82-82 2017年11月査読有り
PLACENTAL-SPECIFIC MICRORNAS WERE TRANSFERRED INTO DECIDUAL NATURAL KILLER CELLS IN THE FIRST TRIMESTER OF PREGNANCY

Manabu Ogoyama, Akihide Ohkuchi, Tomoko Shima, Shigeru Saito, Toshihiro Takizawa

PLACENTA 59 174-174 2017年11月査読有り
MicroRNA expression analysis of peripheral and decidual natural killer cells in early miscarriage

Manabu Ogoyama, Akihide Ohkuchi, Tomoko Shima, Shigeru Saito, Toshihiro Takizawa, Chaw Kyi-Tha-Thu, Xiaohui Song

JOURNAL OF REPRODUCTIVE IMMUNOLOGY 124 83-83 2017年11月査読有り
DICER1 is present in the syncytiotrophoblast of the human full-term placenta

Toshihiro Takizawa, Hironori Takahashi, Chaw Kyi-Tha-Thu, Manabu Ogoyama, Akihide Ohkuchi, Toshiyuki Takeshita, Shigeki Matsubara

JOURNAL OF REPRODUCTIVE IMMUNOLOGY 124 73-73 2017年11月査読有り
New definition and classification of "Hypertensive Disorders of Pregnancy (HDP)"

Watanabe Kazushi, Matsubara Keiichi, Nakamoto Osamu, Ushijima Junko, Ohkuchi Akihide, Koide Keiko, Makino Shintaro, Mimura Kazuya, Morikawa Mamoru, Naruse Katsuhiko, Tanaka Kanji, Nohira Tomoyoshi, Metoki Hirohito, Takeda Satoru, Seki Hiroyuki, Takagi Kenjiro, Yamasaki Mineo, Ichihara Atsuhiro, Kimura Tadashi, Saito Shigeru

HYPERTENSION RESEARCH IN PREGNANCY 5(2) 39-40 2017年11月査読有り
Pregnancy-related thromboembolism and contributing risk factors: From 10 years of experience at a Japanese tertiary obstetrics institute

Ohhashi Mai, Takahashi Hironori, Baba Yosuke, Suzuki Hirotada, Horie Kenji, Usui Rie, Ohkuchi Akihide, Watanabe Takashi, Matsubara Shigeki

HYPERTENSION RESEARCH IN PREGNANCY 5(2) 59-64 2017年11月査読有り
Home blood pressure measurement (HBPM) for the early detection of hypertensive disorders of pregnancy (HDP) in Japanese women: a multicenter prospective study

Suzuki Yoshikatsu, Yamamoto Tamao, Watanabe Kazushi, Yoshimatsu Jun, Matsubara Keiichi, Mimura Kazuya, Tanaka Kanji, Nishizawa Haruki, Makino Shintaro, Nohira Tomoyoshi, Ohkuchi Akihide, Kawabata Ikuno, Mikami Yukiko, Katsuhiko Naruse, Kaoruko Koide, Metoki Kouji, Ishikawa Gen, Morikawa Mamoru, Shiozaki Arihiro, Saitoh Shigeru

HYPERTENSION RESEARCH IN PREGNANCY 5(2) 36-38 2017年11月査読有り
Timing of surgery for placenta previa with suspected abnormally invasive placentation: a test of team competency?

Shigeki Matsubara, Hironori Takahashi, Daisuke Matsubara, Akihide Ohkuchi

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 96(8) 1029-1029 2017年8月査読有り
Response to Dr Sabour: 'Prediction and prevention of hypertensive disorders of pregnancy: a methodological mistake'

Akihide Ohkuchi, Shigeki Matsubara

HYPERTENSION RESEARCH 40(8) 791-791 2017年8月査読有り
Independent risk factors for a small placenta and a small-for-gestational-age infant at 35-41weeks of gestation: An association with circulating angiogenesis-related factor levels at 19-31weeks of gestation

Chikako Hirashima, Akihide Ohkuchi, Kayo Takahashi, Hirotada Suzuki, Koumei Shirasuna, Shigeki Matsubara

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 43(8) 1285-1292 2017年8月査読有り
Advanced glycation end products regulate interleukin-1 beta production in human placenta

Kotomi Seno, Saoko Sase, Ayae Ozeki, Hironori Takahashi, Akihide Ohkuchi, Hirotada Suzuki, Shigeki Matsubara, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna

JOURNAL OF REPRODUCTION AND DEVELOPMENT 63(4) 401-408 2017年8月査読有り
Association of antenatal antithrombin activity with perinatal liver dysfunction: A prospective multicenter study

Mamoru Morikawa, Hirotada Suzuki, Mana Obata-Yasuoka, Michi Kasai, Hiroaki Itoh, Akihide Ohkuchi, Hiromi Hamada, Shigeru Aoki, Naohiro Kanayama, Hisanori Minakami

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 32(7) 1378-1386 2017年7月査読有り
Effect of urine creatinine level during pregnancy on dipstick test

Yosuke Baba, Itsuko Furuta, Tianyue Zhai, Akihide Ohkuchi, Takahiro Yamada, Kayo Takahashi, Shigeki Matsubara, Hisanori Minakami

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 43(6) 967-973 2017年6月査読有り
Hemostatic effect of intrauterine balloon for postpartum hemorrhage with special reference to concomitant use of "holding the cervix" procedure (Matsubara)

Manabu Ogoyama, Hironori Takahashi, Rie Usui, Yosuke Baba, Hirotada Suzuki, Akihide Ohkuchi, Shigeki Matsubara

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 210 281-285 2017年3月査読有り
Endogenous and exogenous miR-520c-3p modulates CD44-mediated extravillous trophoblast invasion

Hironori Takahashi, Akihide Ohkuchi, Tomoyuki Kuwata, Rie Usui, Yosuke Baba, Hirotada Suzuki, Tha Thu Chaw Kyi, Shigeki Matsubara, Shigeru Saito, Toshihiro Takizawa

PLACENTA 50 25-31 2017年2月査読有り
Uterine-fundal hypoechoic mass: a possible ultrasound sign for cesarean scar pregnancy

H. Takahashi, R. Usui, H. Suzuki, Y. Baba, T. Suzuki, T. Kuwata, A. Ohkuchi, S. Matsubara

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY 44(1) 88-92 2017年査読有り
Prediction and prevention of hypertensive disorders of pregnancy

Akihide Ohkuchi, Chikako Hirashima, Kayo Takahashi, Hirotada Suzuki, Shigeki Matsubara

HYPERTENSION RESEARCH 40(1) 5-14 2017年1月査読有り
Supporting less experienced physicians to write a paper: A proposal to introduce such a system on an academic society basis

Shigeki Matsubara, Akihide Ohkuchi, Hisanori Minakami

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 42(12) 1891-1892 2016年12月査読有り
Which type of placenta previa requires blood transfusion more frequently? A new concept of indiscernible edge total previa

Yosuke Baba, Hironori Takahashi, Akihide Ohkuchi, Rie Usui, Shigeki Matsubara

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 42(11) 1502-1508 2016年11月査読有り
Effect of serum from preeclamptic women on inflammatory response in human placental cells

Ayae Ozeki, Kotomi Seno, Akihide Ohkuchi, Shiho Nagayama, Chikako Hirashima, Hirotada Suzuki, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna

JOURNAL OF REPRODUCTIVE IMMUNOLOGY 118 109-109 2016年11月査読有り
Effect of palmitic acid on interleukin-1 beta secretion via NLRP3 inflammasomes in human placental cells

Kotomi Seno, Hirolci Takano, Ayaka Ohtsu, Akihide Ohkuchi, Tadayoshi Karasawa, Masafumi Takahashi, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna

JOURNAL OF REPRODUCTIVE IMMUNOLOGY 118 134-134 2016年11月査読有り
Serum levels of interleukin-8 in normal pregnancy, gestational hypertension, late-onset preeclampsia, early-onset preeclampsia, and HELLP syndrome

Akihide Ohkuchi, Chikako Hirashima, Shiho Nagayama, Kayo Takahashi, Hirotada Suzuki, Hironori Takahashi, Shigeki Matsubara

JOURNAL OF REPRODUCTIVE IMMUNOLOGY 118 137-137 2016年11月査読有り
Differential expression of microRNA between human first trimester villous and extravillous trophoblast cells: PCR array-based approach(和訳中)

Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki

The Journal of Obstetrics and Gynaecology Research 42(Suppl.1) 13 2016年10月
Uterine artery pseudoaneurysm: its occurrence after non-traumatic events, and possibility of "without embolization" strategy

Yosuke Baba, Hironori Takahashi, Akihide Ohkuchi, Hirotada Suzuki, Tomoyuki Kuwata, Rie Usui, Miyuki Saruyama, Manabu Ogoyama, Shiho Nagayama, Hiroyasu Nakamura, Atsushi Ugajin, Shigeki Matsubara

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY 205 72-78 2016年10月査読有り
THE EFFECT OF MODERATE HYPDXIA ON INFLAMMATORY RESPONSES AND AUTOPHAGY IN HUMAN PLACENTAL CELLS

Koumei Shirasuna, Narumi Shimamura, Chihiro Goto, Kotomi Seno, Akihide Ohkuchi, Hisataka Iwata, Takehito Kuwayama

PLACENTA 46 114-114 2016年10月査読有り
Isolated gestational proteinuria preceding the diagnosis of preeclampsia - an observational study

Takahiro Yamada, Mana Obata-Yasuoka, Hiromi Hamada, Yosuke Baba, Akihide Ohkuchi, Shun Yasuda, Kosuke Kawabata, Shiori Minakawa, Chihiro Hirai, Hideto Kusaka, Nao Murabayashi, Yusuke Inde, Michikazu Nagura, Takeshi Umazume, Atsuo Itakura, Makoto Maeda, Norimasa Sagawa, Yasumasa Ohno, Soromon Kataoka, Keiya Fujimori, Yoshiki Kudo, Tomoaki Ikeda, Akihito Nakai, Hisanori Minakami

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 95(9) 1048-1054 2016年9月査読有り
Palmitic acid induces interleukin-1 beta secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells

Koumei Shirasuna, Hiroki Takano, Kotomi Seno, Ayaka Ohtsu, Tadayoshi Karasawa, Masafumi Takahashi, Akihide Ohkuchi, Hirotada Suzuki, Shigeki Matsubara, Hisataka Iwata, Takehito Kuwayama

JOURNAL OF REPRODUCTIVE IMMUNOLOGY 116 104-112 2016年8月査読有り
Urinary protein-to-creatinine ratio indicative of significant proteinuria in normotensive pregnant women

Yosuke Baba, Akihide Ohkuchi, Rie Usui, Hironori Takahashi, Shigeki Matsubara

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 42(7) 784-788 2016年7月査読有り
Postpartum hemorrhage: is angiographically detectable "sac" mandatory for diagnosis of ruptured pseudoaneurysm?

Shigeki Matsubara, Hironori Takahashi, Manabu Ogoyama, Akihide Ohkuchi, Hiroyasu Nakamura, Yoshio Misawa

ARCHIVES OF GYNECOLOGY AND OBSTETRICS 293(6) 1361-1362 2016年6月査読有り
Spontaneous resolution of post-delivery or post-abortion uterine artery pseudoaneurysm: A report of three cases

Hironori Takahashi, Yosuke Baba, Rie Usui, Akihide Ohkuchi, Shigeyoshi Kijima, Shigeki Matsubara

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 42(6) 730-733 2016年6月査読有り
AGEs and HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cells, Resulting in an Enhancement of Monocyte Migration

Koumei Shirasuna, Kotomi Seno, Ayaka Ohtsu, Shogo Shiratsuki, Akihide Ohkuchi, Hirotada Suzuki, Shigeki Matsubara, Shiho Nagayama, Hisataka Iwata, Takehito Kuwayama

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 75(5) 557-568 2016年5月査読有り
Changes in Central Hemodynamics in Women With Hypertensive Pregnancy Between Before and After Delivery

Taishi Fukushima, Kazuo Eguchi, Akihide Ohkuchi, Hiroshi Miyashita, Kazuomi Kario

JOURNAL OF CLINICAL HYPERTENSION 18(4) 329-336 2016年4月査読有り
Gradual improvement of hyperammonemic hepatic encephalopathy after the extirpation of a large uterine leiomyoma in a woman with constipation and liver cirrhosis resulting from autoimmune hepatitis

Koutaro Kunitomo, Akihide Ohkuchi, Satohiro Matsumoto, Masafumi Wada, Ryuichi Himeno, Tatsuyoshi Sakamoto

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 42(3) 353-357 2016年3月査読有り
IS-AC-4-6 The differential expression of microRNA between human first trimester villous and extravillous trophoblast cells : PCR array-based approach(Group 4 Perinatology 2,International Session Award Candidate)

Takahashi Hironori, Ohkuchi Akihide, Ishida Yoichi, Takizawa Toshihiro, Matsubara Shigeki

日本産科婦人科學會雜誌 68(2) 2016年2月1日
Insertion of the Bakri balloon: The earlier, the better?

Shigeki Matsubara, Hironori Takahashi, Akihide Ohkuchi, Alan K. Lefor

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY 56(1) 117-117 2016年2月査読有り
Ambulatory BP monitoring and clinic BP in predicting small-for-gestational-age infants during pregnancy

K. Eguchi, T. Ohmaru, A. Ohkuchi, C. Hirashima, K. Takahashi, H. Suzuki, K. Kario, S. Matsubara, Mitsuaki Suzuki

JOURNAL OF HUMAN HYPERTENSION 30(1) 62-67 2016年1月査読有り
Surgical management of abnormally invasive placenta: is decreased blood loss due to participation of gynecologic oncologists?

Shigeki Matsubara, Hiroyuki Fujiwara, Akihide Ohkuchi, Hironori Takahashi, Alan K. Lefor

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 95(1) 119-119 2016年1月査読有り
Effect of Resident Participation on Outcomes in High-Order Cesarean Deliveries

Shigeki Matsubara, Akihide Ohkuchi, Alan K. Lefor

OBSTETRICS AND GYNECOLOGY 127(1) 164-165 2016年1月査読有り

MISC

560

STRUCTURAL CHARACTERISTICS OF EXOSOMES AND NANOPARTICLES DERIVED FROM TROPHOBLAST CELL LINE BEWO

Shohei Tozawa, Syunya Noguchi, Takanobu Sakurai, Akihide Ohkuchi, Hironori Takahashi, Hiroyuki Fujiwara, Toshihiro Takizawa

PLACENTA 128 131-132 2022年10月
New definition and classification of "Hypertensive Disorders of Pregnancy (HDP)

Shintaro Makino, Jun Takeda, Satoru Takeda, Kazushi Watanabe, Keiichi Matsubara, Osamu Nakamoto, Junko Ushijima, Akihide Ohkuchi, Keiko Koide, Kazuya Mimura, Mamoru Morikawa, Katsuhiko Naruse, Kanji Tanaka, Tomoyoshi Nohira, Hirohito Metoki, Ikuno Kawabata, Kenjiro Takagi, Mineo Yamasaki, Atsuhiro Ichihara, Tadashi Kimura, Shigeru Saito, Hiroyuki Seki

HYPERTENSION RESEARCH IN PREGNANCY 7(1) 1-5 2019年3月
妊娠前から妊娠中にかけての母体末梢血NK細胞数のダイナミックな変動

石田洋一, 大口昭英, 鈴木達也, 高橋宏典, 松原茂樹

日本産科婦人科学会雑誌 71 S.486 2019年2月4日
ヒト初期胎盤の合胞体性栄養膜細胞はmiRNAを生合成している

瀧澤俊広, 高橋宏典, 小古山学, 小古山学, 大口昭英, 竹下俊行, 松原茂樹

日本産科婦人科学会雑誌 71 S.383 2019年2月4日
Outline of the new definition and classification of "Hypertensive Disorders of Pregnancy (HDP)"; a revised JSSHP statement of 2005

Kazushi Watanabe, Keiichi Matsubara, Osamu Nakamoto, Junko Ushijima, Akihide Ohkuchi, Keiko Koide, Shintaro Makino, Kazuya Mimura, Mamoru Morikawa, Katsuhiko Naruse, Kanji Tanaka, Tomoyoshi Nohira, Hirohito Metoki, Ikuno Kawabata, Satoru Takeda, Hiroyuki Seki, Kenjiro Takagi, Mineo Yamasaki, Atsuhiro Ichihara, Tadashi Kimura, Shigeru Saito

HYPERTENSION RESEARCH IN PREGNANCY 6(2) 33-37 2018年11月