最先端循環モニタリング研究開発講座

苅尾 七臣

カリオ カズオミ  (Kazuomi Kario)

基本情報

所属
自治医科大学 医学部 内科学講座循環器内科学部門 教授
学位
(BLANK)

J-GLOBAL ID
200901026266273395
researchmap会員ID
1000220767

学歴

 2

論文

 539
  • Kazuomi Kario, Naoko Tomitani, Koki Haimoto, Keisuke Narita, Ryosuke Komi, Shinji Koba, Hidekazu Shimizu, Hiroyuki Ohbayashi, Takeshi Fujiwara, Tomoyuki Kabutoya, Hajime Kihara, Hiromitsu Sekizuka, Hiroyuki Mizuno, Yasuhisa Abe, Hajime Haimoto, Kenji Harada, Satoshi Hoshide
    Hypertension Research 2024年10月12日  
  • Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
    American journal of hypertension 2024年7月5日  
    BACKGROUND: Previous studies with several limitations have comparatively analyzed the relationship between ambulatory blood pressure (BP) and self-measured BP and biomarkers of organ damage. This study extends this line of research by examining the relationship between ambulatory and self-measured BP and cardiac, renal, and atherosclerotic biomarkers in outpatients at cardiovascular risk. METHODS: In 1,440 practice outpatients who underwent office, ambulatory, and self-measured BP monitoring, we assessed the relationships of each BP with organ damage biomarkers including b-type natriuretic peptide (BNP), echocardiographic left ventricular mass index (LVMI), urine-albumin-creatinine ratio (UACR), and brachial-ankle pulse wave velocity (baPWV). RESULTS: In the comparison of correlation, self-measured systolic BP (SBP) was more strongly correlated to log-transformed (Ln) BNP (n=1,435; r=0.123 vs. r = -0.093, P<0.001), LVMI (n=1,278; r=0.223 vs. r=0.094, P<0.001), Ln-UACR (n=1,435; r=0.244 vs. r=0.154, P=0.010), and baPWV (n=1,360; r=0.327 vs. r=0.115, P<0.001) than daytime ambulatory SBP. In the linear regression models including office, ambulatory, and self-measured SBP, only self-measured SBP was significantly related to Ln-BNP (P=0.016) and LVMI (P<0.001). In the logistic regression models for the top quartile of LVMI, adding self-measured SBP improved the model predictability (P=0.027), but adding daytime ambulatory SBP did not. However, adding daytime ambulatory SBP improved the model predictability in the logistic model including office and self-measured SBP. CONCLUSIONS: Our study findings suggested that self-measured BP was associated with cardiac biomarkers independent of ambulatory BP.
  • Kazuomi Kario, Satoshi Hoshide, Masaki Mogi
    Hypertension Research 47(4) 833-834 2024年4月  
  • Tomonori Watanabe, Hitoshi Hachiya, Hiroaki Watanabe, Kazunori Anno, Takafumi Okuyama, Tomohiko Harunari, Ayako Yokota, Masashi Kamioka, Takahiro Komori, Yuko Torigoe-Kurosu, Hisaki Makimoto, Tomoyuki Kabutoya, Yoshifumi Kimura, Yasushi Imai, Kazuomi Kario
    Journal of arrhythmia 40(2) 363-373 2024年4月  
    BACKGROUND: The precise details of atrial activation around the triangle of Koch (ToK) remain unknown. We evaluated the relationship between the atrial-activation pattern around the ToK and success sites for slow-pathway (SP) modification ablation in slow-fast atrioventricular reentrant tachycardia (AVNRT). METHODS: Thirty patients with slow-fast AVNRT who underwent successful ablation were enrolled. Atrial activation around the ToK during sinus rhythm was investigated using ultra-high-density mapping pre-ablation. The relationships among features of atrial-activation pattern and success sites were examined. RESULTS: Of 30 patients (22 cryoablation; 8 radiofrequency ablation), 26 patients had a collision site of two wavefronts of delayed atrial activation within ToK, indicating a success site. The activation-search function of Lumipoint software, which highlights only atrial activation with a spatiotemporal consistency, showed non-highlighted area on the tricuspid-annulus side of ToK. In 23 of the patients, a spiky potential was recorded at that collision site outside the Lumipoint-highlighted area. Fifteen cryoablation patients with a success site coincident with a collision site outside the Lumipoint-highlighted area had significantly more frequent disappearances of SP after initial cryoablation (46.7% vs. 0%, p = .029), fewer cryoablations (3.7 ± 1.8 vs. 5.3 ± 1.3, p = .045), and shorter procedure times (170 ± 57 vs. 228 ± 91 min, p = .082) compared to the seven cryoablation patients without such sites. Four patients had transient AV block by ablation inside the Lumipoint-highlighted area with fractionated signals, but no patient developed permanent AV block or recurrence post-procedure (median follow-up: 375 days). CONCLUSIONS: SP modification ablation at the collision site of atrial activation of the tricuspid-annulus side along with a spiky potential could provide a better outcome.
  • Tomonori Watanabe, Satoshi Hoshide, Hitoshi Hachiya, Yoshiyuki Yumita, Masafumi Sato, Tadayuki Mitama, Takafumi Okuyama, Hiroaki Watanabe, Ayako Yokota, Masashi Kamioka, Takahiro Komori, Hisaki Makimoto, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 2024年3月26日  
    Lack of the typical nocturnal blood pressure (BP) fall, i.e non-dipper, has been known as a cardiovascular risk. However, the influence of non-dipper on atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI) has been unclear. We investigated the clinical impact of non-dipping as evaluated by 24-hour ambulatory BP monitoring on the long-term outcome of AF recurrence post-PVI in 76 AF patients with a history of increased BP. The PVI procedure was successful in all 76 patients (mean age, 66±9years; antihypertensive medication, 89%; non-paroxysmal AF, 24%). Twenty patients had AF recurrence during a median follow-up of 1138 days. There was no difference in BP levels between the AF recurrence and non-recurrence groups (average 24 h systolic BP:126 ± 17 vs.125 ± 14 mmHg; P = 0.84). On the other hand, the patients with non-dipper had a higher AF recurrence than those with dipper (38.9% vs.15.0%; P = 0.018). In Cox hazard analysis adjusted by age, non-paroxysmal AF and average 24-hr systolic BP level, the non-dipper was an independent predictor of AF recurrence (HR 2.78 [95%CI:1.05-7.34], P = 0.039). Non-dipper patients had a larger left atrial (LA) volume index than the dipper patients (45.9 ± 17.3 vs.38.3 ± 10.2 ml/m2, P = 0.037). Among the 58 patients who underwent high-density voltage mapping in LA, 11 patients had a low-voltage area (LVA) defined as an area with a bipolar voltage < 0.5 mV. However, there was no association of LVA with non-dipper or dipper (22.2% vs.16.1%, P = 0.555). Non-dipper is an independent predictor of AF recurrence post-PVI. Management of abnormal diurnal BP variation post-PVI may be important.

MISC

 221
  • 石井 正将, 大塚 康弘, 池邉 壮, 中村 太志, 辻田 賢一, 藤田 英雄, 的場 哲哉, 興梠 貴英, 大場 祐輔, 甲谷 友幸, 苅尾 七臣, 清末 有宏, 水野 由子, 中山 雅晴, 宮本 恵宏, 佐藤 寿彦, 永井 良三
    日本循環器学会学術集会抄録集 88回 PJ122-2 2024年3月  
  • Masaki Mogi, Yasuhito Ikegawa, Shunsuke Haga, Satoshi Hoshide, Kazuomi Kario
    Hypertension Research 2024年  
    Hypertension, a disease whose prevalence increases with age, induces pathological conditions of ischemic vascular disorders such as cerebral infarction and myocardial infarction due to accelerated arteriosclerosis and circulatory insufficiency of small arteries and sometimes causes hemorrhagic conditions such as cerebral hemorrhage and ruptured aortic aneurysm. On the other hand, as it is said that aging starts with the blood vessels, impaired blood flow associated with vascular aging is the basis for the development of many pathological conditions, and ischemic changes in target organs associated with vascular disorders result in tissue dysfunction and degeneration, inducing organ hypofunction and dysfunction. Therefore, we hypothesized that hypertension is associated with all age-related vascular diseases, and attempted to review the relationship between hypertension and diseases for which a relationship has not been previously well reported. Following our review, we hope that a collaborative effort to unravel age-related diseases from the perspective of hypertension will be undertaken together with experts in various specialties regarding the relationship of hypertension to all pathological conditions. (Figure presented.).
  • 人見泰弘, 今井靖, 桑原政成, 牧元久樹, 興梠貴英, 相澤健一, 大場祐輔, 甲谷友幸, 苅尾七臣, 的場哲哉, 藤田英雄, 永井良三
    日本臨床薬理学会学術総会抄録集(Web) 44th 2023年  
  • Michiaki Nagai, Takeshi Fujiwara, Kazuomi Kario
    Journal of Clinical Hypertension 23(9) 1681-1683 2021年9月1日  
  • Michiaki Nagai, Kazuomi Kario
    Journal of Clinical Hypertension 23(8) 1526-1528 2021年8月1日  

共同研究・競争的資金等の研究課題

 28