研究者業績

苅尾 七臣

カリオ カズオミ  (Kazuomi Kario)

基本情報

所属
自治医科大学 医学部 内科学講座循環器内科学部門 教授
学位
(BLANK)

J-GLOBAL ID
200901026266273395
researchmap会員ID
1000220767

学歴

 2

論文

 272
  • Hiroyuki Mizuno, Kenji Harada, Kenta Fujimura, Kazuomi Kario
    European heart journal. Cardiovascular Imaging 2025年1月2日  
  • Kazuomi Kario, Naoko Tomitani, Koki Haimoto, Keisuke Narita, Ryosuke Komi, Shinji Koba, Hidekazu Shimizu, Hiroyuki Ohbayashi, Takeshi Fujiwara, Tomoyuki Kabutoya, Hajime Kihara, Hiromitsu Sekizuka, Hiroyuki Mizuno, Yasuhisa Abe, Hajime Haimoto, Kenji Harada, Satoshi Hoshide
    Hypertension Research 2024年10月12日  
  • Yasuhiro Hitomi, Yasushi Imai, Masanari Kuwabara, Yusuke Oba, Tomoyuki Kabutoya, Kazuomi Kario, Hisaki Makimoto, Takahide Kohro, Eiichi Shiraki, Naoyuki Akashi, Hideo Fujita, Tetsuya Matoba, Yoshihiro Miyamoto, Arihiro Kiyosue, Kenichi Tsujita, Masaharu Nakayama, Ryozo Nagai
    International journal of cardiology. Heart & vasculature 54 101507-101507 2024年10月  
    BACKGROUND: Polypharmacy is associated with an increased risk of adverse events due to the higher number of drugs used. This is particularly notable in patients with chronic coronary syndrome (CCS), who are known to use a large number of drugs. Therefore, we investigated polypharmacy in patients with CCS, using CLIDAS, a multicenter database of patients who underwent percutaneous coronary intervention. METHOD AND RESULTS: Between 2017 and 2020, 1411 CCS patients (71.5 ± 10.5 years old; 77.3 % male) were enrolled. The relationship between cardiovascular events occurring during the median follow-up of 514 days and the number of drugs at the time of PCI was investigated. The median number of drugs prescribed was nine. Major adverse cardiovascular events (MACE), defined as cardiovascular death, myocardial infarction, stroke, heart failure, transient ischemic attack, or unstable angina, occurred in 123 patients, and all-cause mortality occurred in 68 patients. For each additional drug, the adjusted hazard ratios for MACE and all-cause mortality increased by 2.069 (p = 0.003) and 1.102 (p = 0.010). The adjusted hazard ratios for MACE and all-cause mortality were significantly higher in the group using nine or more drugs compared to the group using eight or fewer drugs (1.646 and 2.253, both p < 0.001). CONCLUSION: This study showed that an increase in the number of drugs used for CCS may be associated with MACE and all-cause mortality. In patients with CCS, it might be beneficial to minimize the number of medications as much as possible, while managing comorbidities and using guideline-recommended drugs.
  • Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
    American journal of hypertension 2024年7月5日  
    BACKGROUND: Previous studies with several limitations have comparatively analyzed the relationship between ambulatory blood pressure (BP) and self-measured BP and biomarkers of organ damage. This study extends this line of research by examining the relationship between ambulatory and self-measured BP and cardiac, renal, and atherosclerotic biomarkers in outpatients at cardiovascular risk. METHODS: In 1,440 practice outpatients who underwent office, ambulatory, and self-measured BP monitoring, we assessed the relationships of each BP with organ damage biomarkers including b-type natriuretic peptide (BNP), echocardiographic left ventricular mass index (LVMI), urine-albumin-creatinine ratio (UACR), and brachial-ankle pulse wave velocity (baPWV). RESULTS: In the comparison of correlation, self-measured systolic BP (SBP) was more strongly correlated to log-transformed (Ln) BNP (n=1,435; r=0.123 vs. r = -0.093, P<0.001), LVMI (n=1,278; r=0.223 vs. r=0.094, P<0.001), Ln-UACR (n=1,435; r=0.244 vs. r=0.154, P=0.010), and baPWV (n=1,360; r=0.327 vs. r=0.115, P<0.001) than daytime ambulatory SBP. In the linear regression models including office, ambulatory, and self-measured SBP, only self-measured SBP was significantly related to Ln-BNP (P=0.016) and LVMI (P<0.001). In the logistic regression models for the top quartile of LVMI, adding self-measured SBP improved the model predictability (P=0.027), but adding daytime ambulatory SBP did not. However, adding daytime ambulatory SBP improved the model predictability in the logistic model including office and self-measured SBP. CONCLUSIONS: Our study findings suggested that self-measured BP was associated with cardiac biomarkers independent of ambulatory BP.
  • Kazuomi Kario, Satoshi Hoshide, Masaki Mogi
    Hypertension Research 47(4) 833-834 2024年4月  
  • Tomonori Watanabe, Hitoshi Hachiya, Hiroaki Watanabe, Kazunori Anno, Takafumi Okuyama, Tomohiko Harunari, Ayako Yokota, Masashi Kamioka, Takahiro Komori, Yuko Torigoe-Kurosu, Hisaki Makimoto, Tomoyuki Kabutoya, Yoshifumi Kimura, Yasushi Imai, Kazuomi Kario
    Journal of arrhythmia 40(2) 363-373 2024年4月  
    BACKGROUND: The precise details of atrial activation around the triangle of Koch (ToK) remain unknown. We evaluated the relationship between the atrial-activation pattern around the ToK and success sites for slow-pathway (SP) modification ablation in slow-fast atrioventricular reentrant tachycardia (AVNRT). METHODS: Thirty patients with slow-fast AVNRT who underwent successful ablation were enrolled. Atrial activation around the ToK during sinus rhythm was investigated using ultra-high-density mapping pre-ablation. The relationships among features of atrial-activation pattern and success sites were examined. RESULTS: Of 30 patients (22 cryoablation; 8 radiofrequency ablation), 26 patients had a collision site of two wavefronts of delayed atrial activation within ToK, indicating a success site. The activation-search function of Lumipoint software, which highlights only atrial activation with a spatiotemporal consistency, showed non-highlighted area on the tricuspid-annulus side of ToK. In 23 of the patients, a spiky potential was recorded at that collision site outside the Lumipoint-highlighted area. Fifteen cryoablation patients with a success site coincident with a collision site outside the Lumipoint-highlighted area had significantly more frequent disappearances of SP after initial cryoablation (46.7% vs. 0%, p = .029), fewer cryoablations (3.7 ± 1.8 vs. 5.3 ± 1.3, p = .045), and shorter procedure times (170 ± 57 vs. 228 ± 91 min, p = .082) compared to the seven cryoablation patients without such sites. Four patients had transient AV block by ablation inside the Lumipoint-highlighted area with fractionated signals, but no patient developed permanent AV block or recurrence post-procedure (median follow-up: 375 days). CONCLUSIONS: SP modification ablation at the collision site of atrial activation of the tricuspid-annulus side along with a spiky potential could provide a better outcome.
  • Tomonori Watanabe, Satoshi Hoshide, Hitoshi Hachiya, Yoshiyuki Yumita, Masafumi Sato, Tadayuki Mitama, Takafumi Okuyama, Hiroaki Watanabe, Ayako Yokota, Masashi Kamioka, Takahiro Komori, Hisaki Makimoto, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 2024年3月26日  
    Lack of the typical nocturnal blood pressure (BP) fall, i.e non-dipper, has been known as a cardiovascular risk. However, the influence of non-dipper on atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI) has been unclear. We investigated the clinical impact of non-dipping as evaluated by 24-hour ambulatory BP monitoring on the long-term outcome of AF recurrence post-PVI in 76 AF patients with a history of increased BP. The PVI procedure was successful in all 76 patients (mean age, 66±9years; antihypertensive medication, 89%; non-paroxysmal AF, 24%). Twenty patients had AF recurrence during a median follow-up of 1138 days. There was no difference in BP levels between the AF recurrence and non-recurrence groups (average 24 h systolic BP:126 ± 17 vs.125 ± 14 mmHg; P = 0.84). On the other hand, the patients with non-dipper had a higher AF recurrence than those with dipper (38.9% vs.15.0%; P = 0.018). In Cox hazard analysis adjusted by age, non-paroxysmal AF and average 24-hr systolic BP level, the non-dipper was an independent predictor of AF recurrence (HR 2.78 [95%CI:1.05-7.34], P = 0.039). Non-dipper patients had a larger left atrial (LA) volume index than the dipper patients (45.9 ± 17.3 vs.38.3 ± 10.2 ml/m2, P = 0.037). Among the 58 patients who underwent high-density voltage mapping in LA, 11 patients had a low-voltage area (LVA) defined as an area with a bipolar voltage < 0.5 mV. However, there was no association of LVA with non-dipper or dipper (22.2% vs.16.1%, P = 0.555). Non-dipper is an independent predictor of AF recurrence post-PVI. Management of abnormal diurnal BP variation post-PVI may be important.
  • Masaki Mogi, Yasuhito Ikegawa, Shunsuke Haga, Satoshi Hoshide, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 2024年3月15日  
    Hypertension, a disease whose prevalence increases with age, induces pathological conditions of ischemic vascular disorders such as cerebral infarction and myocardial infarction due to accelerated arteriosclerosis and circulatory insufficiency of small arteries and sometimes causes hemorrhagic conditions such as cerebral hemorrhage and ruptured aortic aneurysm. On the other hand, as it is said that aging starts with the blood vessels, impaired blood flow associated with vascular aging is the basis for the development of many pathological conditions, and ischemic changes in target organs associated with vascular disorders result in tissue dysfunction and degeneration, inducing organ hypofunction and dysfunction. Therefore, we hypothesized that hypertension is associated with all age-related vascular diseases, and attempted to review the relationship between hypertension and diseases for which a relationship has not been previously well reported. Following our review, we hope that a collaborative effort to unravel age-related diseases from the perspective of hypertension will be undertaken together with experts in various specialties regarding the relationship of hypertension to all pathological conditions.
  • Kazuomi Kario, Ayako Okura, Satoshi Hoshide, Masaki Mogi
    Hypertension research : official journal of the Japanese Society of Hypertension 2024年3月5日  
    Thirty-year % increase of adults with hypertension in the European/ Americas and South-East Asia/ Western Pacific (WHO region). Create using the data from: World Health Organization. Global report on hypertension: the race against a silent killer. Geneva, Switzerland: 2023.
  • 弓田 馨之, 渡部 智紀, 星出 聡, 渡邉 裕昭, 上岡 正志, 蜂谷 仁, 今井 靖, 苅尾 七臣
    日本循環器学会学術集会抄録集 88回 ECC-3 2024年3月  
  • 横田 彩子, 甲谷 友幸, 三玉 唯由季, 奥山 貴文, 渡邉 裕昭, 上岡 正志, 小森 孝洋, 渡部 智紀, 牧元 久樹, 今井 靖, 苅尾 七臣
    日本循環器学会学術集会抄録集 88回 PJ019-3 2024年3月  
  • 渡邉 裕昭, 牧元 久樹, 興梠 貴英, 菅沼 雅徳, 岡谷 貴之, 奥山 貴文, 横田 彩子, 上岡 正志, 小森 孝洋, 渡部 智紀, 甲谷 友幸, 今井 靖, 苅尾 七臣
    日本循環器学会学術集会抄録集 88回 PJ047-4 2024年3月  
  • 上岡 正志, 渡部 智紀, 渡邉 裕昭, 牧元 久樹, 奥山 貴文, 横田 彩子, 小森 孝洋, 甲谷 友幸, 今井 靖, 苅尾 七臣
    日本循環器学会学術集会抄録集 88回 PJ071-5 2024年3月  
  • 渡部 智紀, 奥山 貴文, 渡邉 裕昭, 上岡 正志, 牧元 久樹, 三玉 唯由季, 佐藤 雅史, 横田 彩子, 小森 孝洋, 甲谷 友幸, 今井 靖, 苅尾 七臣
    日本循環器学会学術集会抄録集 88回 PJ092-3 2024年3月  
  • 三玉 唯由季, 甲谷 友幸, 奥山 貴文, 渡邉 裕昭, 横田 彩子, 上岡 正志, 渡部 智紀, 小森 孝洋, 牧元 久樹, 今井 靖, 苅尾 七臣
    日本循環器学会学術集会抄録集 88回 PJ116-5 2024年3月  
  • 石山 裕介, 大場 祐輔, 牧元 久樹, 菅沼 雅徳, 岡谷 貴之, 興梠 貴英, 苅尾 七臣
    日本循環器学会学術集会抄録集 88回 PJ047-3 2024年3月  
  • Kazuomi Kario, Satoshi Hoshide, Masaki Mogi
    Hypertension Research 47(2) 251-252 2024年2月  
  • Satoshi Hoshide, Masaki Mogi, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 47(2) 253-254 2024年2月  
  • 今井 靖, 苅尾 七臣
    日本臨床薬理学会学術総会抄録集 44回 3-3 2024年1月  
  • 甲谷 友幸, 関 満, 柏原 香菜, 藤村 研太, 今井 靖, 苅尾 七臣, 古井 貞浩, 鈴木 峻, 岡 健介, 松原 大輔, 佐藤 智幸, 金子 政弘, 友保 貴博, 岡 徳彦
    日本成人先天性心疾患学会雑誌 13(1) 161-161 2024年1月  
  • 藤村 研太, 甲谷 友幸, 関 満, 久保田 香菜, 今井 靖, 苅尾 七臣, 古井 貞浩, 鈴木 峻, 岡 健介, 松原 大輔, 佐藤 智幸, 金子 政弘, 友保 貴博, 岡 徳彦
    日本成人先天性心疾患学会雑誌 13(1) 173-173 2024年1月  
  • Keisuke Narita, Zihan Yuan, Nobuhiko Yasui, Satoshi Hoshide, Kazuomi Kario
    JACC. Advances 3(1) 100737-100737 2024年1月  
    BACKGROUND: A simple ambulatory measure of cardiac function could be helpful for monitoring heart failure patients. OBJECTIVES: The purpose of this paper was to determine whether a novel pulse waveform analysis using data obtained by our developed multisensor-ambulatory blood pressure monitoring (ABPM) device, the 'Sf/Am' ratio, is associated with echocardiographic left ventricular ejection fraction (LVEF). METHODS: Multisensor-ABPM was conducted twice at baseline in 20 heart failure (HF) patients with HF-reduced LVEF or HF-preserved LVEF (median age 66 years, male 65%) and over a 6- to 12-month follow-up after patient-tailored treatment. We assessed the changes in the pulse waveform index Sf/Am and LVEF that occurred between the baseline and follow-up. The Sf/Am consists of the area of the ejection part in the square forward wave (Sf) and the amplitude of the measured wave (Am). We divided the patients into the recovered (n = 11) and not-recovered (n = 9) groups defined by a ≥10% increase in LVEF. RESULTS: Although the ambulatory BP levels and variabilities did not change in either group, the Sf/Am increased significantly in the recovered group (baseline 21.4 ± 4.5; follow-up, 25.6 ± 3.7, P = 0.004). The not-recovered group showed no difference between the baseline and follow-up. The follow-up/baseline Sf/Am ratio was significantly associated with the LVEF ratio (r = 0.469, P = 0.037). The Sf/Am was significantly correlated with the LVEF in overall measurements (n = 40, r = 0.491, P = 0.001). CONCLUSIONS: These results demonstrated that a novel noninvasive pulse waveform index, the Sf/Am measured by multisensor-ABPM is associated with LVEF. The Sf/Am may be useful for estimating cardiac function.
  • Kazuomi Kario, Satoshi Hoshide, Masaki Mogi
    Hypertension research : official journal of the Japanese Society of Hypertension 46(12) 2557-2560 2023年12月  
  • Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
    Journal of clinical medicine 12(23) 2023年11月22日  
    Although various guidelines for cardiovascular disease prevention have been established, the optimal drug therapy is often not implemented due to poor medication adherence and the clinical inertia of healthcare practitioners. Polypill strategies are one solution to this problem. Previous studies have established the usefulness of polypills, i.e., combination tablets including three or more medications, for the prevention of cardiovascular disease. For this purpose, the polypills generally contain an antiplatelet medication, an antihypertensive medication, and a statin. For the specific management of hypertension, combination therapy including more than two classes of antihypertensive medications is recommended by most international guidelines. Combination tablets including two classes of antihypertensive medications, such as renin-angiotensin system (RAS) inhibitors (angiotensin-converting enzyme inhibitors [ACEIs] and angiotensin receptor blockers [ARBs]) and Ca-channel blockers or thiazide diuretics, have been reported to be useful for cardiovascular disease prevention and lowering blood pressure (BP) levels. The use of RAS inhibitors is recommended for a wide range of complications, including diabetes, chronic heart failure, and chronic kidney disease. The combination of an RAS inhibitor and diuretic or Ca-channel blocker is thus recommended for the management of hypertension. Finally, we expect that novel medications such as angiotensin receptor neprilysin inhibitors (ARNIs) and sodium glucose cotransporter 2 inhibitors (SGLT2i), which have a more diverse range of effects in hypertension, heart failure, or diabetes, may be a solution to the problem of polypharmacy. Evidence is accumulating on the benefits of polypill strategies in cardiovascular disease prevention. Combination tablets are also effective for the treatment of hypertension.
  • David E. Kandzari, Raymond R. Townsend, Kazuomi Kario, Felix Mahfoud, Michael A. Weber, Roland E. Schmieder, Stuart Pocock, Konstantinos Tsioufis, Dimitrios Konstantinidis, James Choi, Cara East, Lucas Lauder, Debbie L. Cohen, Taisei Kobayashi, Axel Schmid, David P. Lee, Adrian Ma, Joachim Weil, Tolga Agdirlioglu, Markus P. Schlaich, Sharad Shetty, Chandan M. Devireddy, Janice Lea, Jiro Aoki, Andrew S.P. Sharp, Richard Anderson, Martin Fahy, Vanessa DeBruin, Sandeep Brar, Michael Böhm, Yale Wang, Desmond Jay, Brent McLaurin, Carl Lomboy, Suhail Allaqaband, Fuad Jan, Bharat Gummadi, Marc Litt, Fidel Garcia, Jasvindar Singh, Angela Brown, James Choi, Ashley Paul, Andrew Sharp, James Coulson, Aravinda Nanjundappa, Ganpat Thakker, James Campbell, Benjamin Honton, Bruno Farah, Manesh Patel, Antonio Gutierrez, Crystal Tyson, Laura Svetkey, Marat Fudim, Neha Pagidipati, Schuyler Jones, Sreekanth Vemulapalli, Chandan Devireddy, Ambar Kulshreshtha, Bryan Wells, Janice Lea, Bryan Batson, Robert Wilkins, Faisal Sharif, Abdullahi Mohamed Khair, Abhishek Wilson Pallippattu, Aishah Matar Alhmoudi, Brian Gaffney, Christian Cawley, Colin Gorry, Hanan Hamed, Jennifer Carron, John Birrane, Liesbeth Rosseel, Mattia Lunardi, Michael Cronin, Myles McKittrick, Naeif Almagal, Noman Khalid, Qussai Shehahd, Shirjeel Shahzad, Simone Fezzi, Stanislav Tyulkin, Xavier Armario Bel, Sanjit Jolly, Gordon Yip, Jon-David Schwalm, Michael Tsang, Shamir Mehta, Philipp C. Lurz, Christian Binner, Danilo Obradovic, Florian Fahr, Ines Richter, Johannes Rotta detto Loria, Karl Fengler, Karl-Philipp Rommel, Mateo Marin Cuartas, Matthias Lerche, Philipp Hartung, Phillip Münch, Robert Höllriegel, Silke John, Satoru Otsuji, Hirofumi Kusumoto, Hiroto Tamaru, Kasumi Ishibuchi, Katsuyuki Hasegawa, Ken Sugimoto, Mikio Kakishita, Rui Ishii, Shin Takiuchi, Shingo Yasuda, Sho Nakabayashi, Wataru Yamamoto, Yorihiko Higashino, Yuji Shimatani, Yusuke Taniguchi, Konstantinos Tsioufis, Alexandros Kasiakogias, Dimitris Konstantinidis, Eirini Andrikou, Konstantinos Konstantinou, Kyriakos Dimitriadis, Theodoros Kalos, Debbie Cohen, Garvey Rene, Jordana Cohen, Maria Bonanni, Matthew Denker, Rasi Wickramisinghe, Robert Wilensky, Tai Kobayashi, Venkatesh Anjan, Yonghong Huan, Walter Herbert Haught, Joshua Krasnow, Alejandro Vasquez, Carl Gessler, Christopher Roth, David Drenning, Enrique Velasquez, George Soliman, James Murphy, Kaushik Jain, Michael Butler, Mihir Kanitkar, Phillip Laney, Ross Hunter, Shi-Chi Cheng, Thomas Wright, Walter Herbert Haught, Neil Chapman, Ahran Arnold, Alexandra Nowbar, Azara Janmohamed, Ben Corden, Christopher Cook, Christopher Rajkumar, Daniel Keene, David Thompson, Henry Seligman, James Howard, Justin Davies, Mark Sweeney, Matthew Shun-Shin, Michael Foley, Nicholas Quaife, Rasha Al-Lamee, Savvas Hadjiphilippou, Sayan Sen, Yousif Ahmad, Kazuomi Kario, Hayato Shimizu, Hirotaka Waki, Keisuke Narita, Masahisa Shimpo, Satoshi Hoshide, Takahiro Komori, Yukako Ogoyama, Yukiyo Ogata, Yusuke Oba, Mohanned Bisharat, Anton Lishmanov, Mohanned Bisharat, Travis Jeffords, Magdi Ghali, Beth Chia, Rachel Onsrud, Randolph Rough, Jiro Aoki, Daijiro Tomii, Fumiko Mori, Hosei Kikushima, Kai Ninomiya, Kazuyuki Yahagi, Kengo Tanabe, Kosuke Nakamura, Kota Komiyama, Masaaki Nakase, Masahiko Asami, Naoto Setoguchi, Tetsu Tanaka, Yu Horiuchi, Yusuke Watanabe, Dmitriy Feldman, Geoffrey Bergman, Ines Sherifi, Luke Kim, Nivee Amin, Robert Minutello, S. Chiu Wong, Stephen McCullough, Richard D'Souza, Andrew Sharp, Hibba Kurdi, Richard D'Souza, Sarah Statton, Tony Watkinson, Barry Bertolet, Amit Gupta, Benjamin Blossom, Chris Bell, Douglas Hill, Francisco Sierra, James Johnson, John Estess, Joseph Adams, Katie McDuffie, Lee Ferguson, Nelson Little, Richard Dane Ballard, Roger Williams, Wanda Ikeda, William Calhoun, William Carroll, Avneet Singh, Benjamin Hirsh, Perwaiz Meraj, Rajiv Jauhar, Harsh Golwala, Jose Rueda, Kellie Graham, Ramsey Al-Hakim, Robert Rope, David Kandzari, Dariush Bahrami, Denise Reedus, Shukri David, Iram Rehman, Khalid Zakaria, Nishit Choksi, Samer Kazziha, Sarwan Kumar, Souheil Saba, Susan Steigerwalt, Yassir Sirajeldin, Omar Hyder, Herbert Aronow, Andrea Connors, Douglas Shemin, Clare Bent, Terry Levy, Vivek Kodoth, Markus Schlaich, Marcio Kiuchi, Revathy Carnagarin, Sharad Shetty, Sabino Torre, Howard Levitt, Lin Chen, Sarah Fan, Sergio Waxman, Wendy Porr, George Mangos, Brendan Smyth, Cathie Lane, Mark Sader, Kirit Kumar Patel, Anjani Rao, Brett Milford, Guneet Ahluwalia, Jaqueline Sennott, Justin Field, Nihar Jena, Stacy Loree, John Graham, Abdul Al-Hesayen, Akshay Bagai, Junya Shite, Amane Kozuki, Atsushi Suzuki, Eri Masuko, Fumitaka Soga, Hiroyuki Asada, Hiroyuki Shibata, Ryoji Nagoshi, Ryudo Fujiwara, Shokan Kyo, Tomohiro Miyata, Yoichi Kijima, Joachim Weil, Lena Griesinger, Lukas Hafer, Rene-Alexander Starick, Sebastian Keil, Tolga Agdirlioglu, Udo Desch, Shigeru Saito, Eiji Koyama, Futoshi Yamanaka, Hiroaki Yokoyama, Kazuki Tobita, Koki Shishido, Masashi Yamaguchi, Masato Murakami, Noriaki Moriyama, Saeko Takahashi, Shingo Mizuno, Shohei Yokota, Takahiro Hayashi, Takashi Yamada, Tamiharu Yamagishi, Yoichi Sugiyama, Yuka Mashimo, Yusuke Tamaki, Yutaka Tanaka, David Lee, Adrian Ma, Alan Yeung, Thomas Noel, Ernesto Umana, John Katopodis, William Dixon, Tony Walton, Adam Rischin, Adrian Chee, Alexandra Leaney, Himavan Fernando, Ingrid Hopper, Jason Bloom, Jessica Fairley, Julia Stehli, Julian Segan, Meenal Sharma, Melissa Fitzgerald, Michelle Papandony, Naomi Whyler, Samer Noaman, Shazeea Ali, Brian Jefferson, David Reyes, Thomas Johnston, Michael Böhm, Alexander Höfling, Ann-Kathrin Berger, Bodo Cremers, Dominic Millenaar, Felix Mahfoud, Ina Zivanovic, Jelena Lucic, Juliane Dederer, Lucas Lauder, Patrick Fischer, Saarraangan Kulenthiran, Sebastian Ewen, Yvonne Bewarder, Roland Schmieder, Agnes Bosch, Axel Schmid, Christian Ott, Dennis Kannenkeril, Ertan Akarca, Iris Kistner, Julie Kolwelter, Karl Bihlmaier, Kristina Striepe, Marina Karg, Merve Günes-Altan, Stefanie Sofia Anna Friedrich, Susanne Jung, Thomas Dienemann, Antonios Ziakas, Antonios Kouparanis, Areti Pagiantza, Emmanouela Peteinidou, Matthaios Didagelos, Polykarpos Akis Psochias, Mehdi Shishehbor, Ashley Meade, Elena Linetsky, Monique Robinson, John Kotter, Khaled Ziada, John Kotter, William Bachinsky, Alex Garton, Jason Stuck, Vasilios Papademetriou, Annise Chung, Ping Li, Sameer Nagpal, Michael Remetz, Samit Shah, Shannon Lynch
    Journal of the American College of Cardiology 82(19) 1809-1823 2023年11月  
  • Masaki Mogi, Satoshi Hoshide, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 46(11) 2445-2446 2023年11月  
  • Satoshi Hoshide, Masaki Mogi, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 46(10) 2262-2263 2023年10月  
  • Yusuke Oba, Hiroshi Funayama, Masafumi Sato, Hisaya Kobayashi, Kenji Harada, Mamoru Arakawa, Koji Kawahito, Kazuomi Kario
    European Heart Journal - Imaging Methods and Practice 1(2) 2023年9月8日  
  • Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
    Hypertension (Dallas, Tex. : 1979) 2023年9月6日  
    BACKGROUND: Although blood pressure variability (BPV) is reported to be associated with cardiovascular prognoses, it has not been established whether ambulatory BPV ([ABPV], ie, short-term 24-hour BPV) or home BPV ([HBPV], day-to-day BPV) is a superior clinical marker. METHODS: We analyzed the associations of ABPV and HBPV with cardiovascular prognoses and biomarkers in 1314 hypertensive outpatients who underwent both home and ambulatory BP measurements in the J-HOP study (Japan Morning-Surge Home Blood Pressure). BPV was evaluated by the SD, coefficient of variation, and average real variability of the patients' 24-hour ambulatory and home systolic BP values. RESULTS: During the median 7.0-year follow-up, 109 cardiovascular events occurred. All SD, coefficient of variation, and average real variability values of the HBPV were significantly associated with cardiovascular risk even after adjusting by average 24-hour ambulatory systolic BP and each ABPV value: 1 SD of hazard ratio (95% CI) for the SD, 1.36 (1.14-1.63); coefficient of variation, 1.38 (1.16-1.66); and average real variability 1.29 (1.10-1.51) of HBPV. The ABPV parameters did not exhibit comparable relationships. The cardiovascular risk spline curves showed a trend toward increased risks with increasing HBPV parameters. There were no differences between ABPV and HBPV in the relationships with B-type natriuretic peptide and the urine albumin-creatine ratio. CONCLUSIONS: In this comparative analysis of ambulatory and home BP monitoring values in individuals with hypertension, ABPV was not significantly associated with cardiovascular prognosis adjusted by average BP level, and HBPV was suggested to have modest superiority in predicting cardiovascular prognosis compared with ABPV.
  • 朝日 善治, 甲谷 友幸, 奥山 貴文, 渡邉 裕昭, 上岡 正志, 渡部 智紀, 小森 孝洋, 牧元 久樹, 今井 靖, 苅尾 七臣
    日本内科学会関東地方会 689回 29-29 2023年9月  
  • 黒木 安優香, 森田 愛理, 大場 祐輔, 和地 純佳, 石山 裕介, 清水 勇人, 船山 大, 苅尾 七臣
    日本内科学会関東地方会 689回 29-29 2023年9月  
  • 鈴木 規泰, 鈴木 悠介, 大場 祐輔, 船山 大, 苅尾 七臣
    日本心臓病学会学術集会抄録 71回 C-5 2023年9月  
  • Masashi Kamioka, Hisaki Makimoto, Tomonori Watanabe, Hiroaki Watanabe, Takafumi Okuyama, Takashi Kaneshiro, Naoko Hijioka, Ayako Yokota, Takahiro Komori, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 25(9) 2023年8月2日  
    AIMS: The relationship between local unipolar voltage (UV) in the pulmonary vein (PV)-ostia and left atrial wall thickness (LAWT) and the utility of these parameters as indices of outcome after atrial fibrillation (AF) ablation remain unclear. METHODS AND RESULTS: Two-hundred seventy-two AF patients who underwent AF ablation were enrolled. Unipolar voltage of PV-ostia was measured using a CARTO system, and LAWT was measured using computed tomography. The primary endpoint was atrial tachyarrhythmia (ATA) recurrence including AF. The ATA recurrence was documented in 74 patients (ATA-Rec group). The UV and LAWT of the bilateral superior PV roof to posterior and around the right-inferior PV in the ATA-Rec group were significantly greater than in patients without ATA recurrence (ATA-Free group) (P < 0.001). The UV had a strong positive correlation with LAWT (R2 = 0.446, P < 0.001). The UV 2.7 mV and the corresponding LAWT 1.6 mm were determined as the cut-off values for ATA recurrence (P < 0.001, respectively). Multisite LA high UV (HUV, ≥4 areas of >2.7 mV) or multisite LA wall thickening (≥5 areas of >1.6 mm), defined as LA hypertrophy (LAH), was related to higher ATA recurrence. Among 92 LAH patients, 66 had HUV (LAH-HUV) and the remaining 26 had low UV (LAH-LUV), characterized by history of non-paroxysmal AF and heart failure, reduced LV ejection fraction, or enlarged LA. In addition, LAH-LUV showed the worst ablation outcome, followed by LAH-HUV and No LAH (log-rank P < 0.001). CONCLUSION: Combining UV and LAWT enables us to stratify recurrence risk and suggest a tailored ablation strategy according to LA tissue properties.
  • Ayako Yokota, Tomoyuki Kabutoya, Tadayuki Mitama, Takafumi Okuyama, Hiroaki Watanabe, Masashi Kamioka, Tomonori Watanabe, Takahiro Komori, Yasushi Imai, Kazuomi Kario
    Journal of arrhythmia 39(4) 574-579 2023年8月  
    BACKGROUND: While most VVI pacemakers in bradycardic patients are set to a low limit of 60/min, the optimal lower limit rate for VVI pacemakers in atrial fibrillation has not been established. Although an increase in heart rate within the normal range in the setting of a VVI pacemaker might be expected to lead to an increase in cardiac output with the shortening of the diastolic time, the changes in cardiac output at different pacemaker settings have not been fully clarified. METHODS: We included 11 patients with bradycardic atrial fibrillation who had VVI pacemakers implanted. Stroke volume was measured using the electrical cardiometry method (AESCULONⓇ mini; Osypka Medical) without pacing and at ventricular pacings of 60, 70, 80, and 90/min. RESULTS: Stroke volume decreased stepwise at ventricular pacing rates of 60, 70, 80, and 90/min (63.6 ± 11.2, 61.9 ± 10.6, 59.3 ± 12.2, and 57.5 ± 12.2 mL, p < .001), but cardiac output increased (3.81 ± 0.67, 4.33 ± 0.74, 4.74 ± 0.97, and 5.17 ± 1.09 L/min, p < .001). The rate of increase in cardiac output at a pacing rate of 70/min compared to 60/min correlated with left ventricular end-systolic volume (r = 0.711, p = .014). CONCLUSIONS: Cardiac output increased at a pacing rate of 70 compared to 60 in bradycardic atrial fibrillation patients, and the rate of increase in cardiac output was greater in those with larger left ventricular end-systolic volume.
  • Masaki Mogi, Satoshi Hoshide, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 46(8) 1827-1828 2023年8月  
  • Kazuomi Kario, Naoyuki Hasebe, Ken Okumura, Takeshi Yamashita, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Yukihiro Koretsune, Wataru Shimizu, Shinya Suzuki, Hiroyuki Tsutsui, Kazunori Toyoda, Atsushi Hirayama, Masahiro Yasaka, Takenori Yamaguchi, Satoshi Teramukai, Tetsuya Kimura, Yoshiyuki Morishima, Atsushi Takita, Hiroshi Inoue
    Hypertension research : official journal of the Japanese Society of Hypertension 2023年7月11日  
    The benefits of direct oral anticoagulants (DOACs) and warfarin in elderly Japanese patients with non-valvular atrial fibrillation (NVAF) and high home systolic blood pressure (H-SBP) are unclear. This sub-cohort study of the ANAFIE Registry estimated the incidence of clinical outcomes in patients receiving anticoagulant therapy (warfarin and DOACs) stratified by H-SBP levels (<125 mmHg, ≥125-<135 mmHg, ≥135-<145 mmHg and ≥145 mmHg). Of the overall ANAFIE population, 4933 patients who underwent home blood pressure (H-BP) measurements were analyzed; 93% received OACs (DOACs: 3494, 70.8%; warfarin: 1092, 22.1%). In the warfarin group, at <125 mmHg and ≥145 mmHg, the respective incidence rates (per 100 person-years) were 1.91 and 5.89 for net cardiovascular outcome (a composite of stroke/systemic embolic events (SEE) and major bleeding), 1.31 and 3.39 for stroke/SEE, 0.59 and 3.91 for major bleeding, 0.59 and 3.43 for intracranial hemorrhage (ICH), and 4.01 and 6.24 for all-cause death. Corresponding incidence rates in the DOACs group were 1.64 and 2.65, 1.00 and 1.88, 0.78 and 1.69, 0.55 and 1.31, and 3.43 and 3.51. In warfarin-treated patients, the incidence rates of net cardiovascular outcome, stroke/SEE, major bleeding, and ICH were significantly increased at H-SBP ≥ 145 mmHg versus <125 mmHg. In the DOAC group, although there was no significant difference between H-SBP < 125 mmHg and ≥145 mmHg, the incidence rates of these events tended to increase at ≥145 mmHg. These results suggest that strict BP control guided by H-BP is required in elderly NVAF patients receiving anticoagulant therapy.
  • Satoshi Hoshide, Masaki Mogi, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 46(7) 1636-1637 2023年7月  
  • Kazuomi Kario, Satoshi Hoshide, Masaki Mogi
    Hypertension research : official journal of the Japanese Society of Hypertension 46(6) 1357-1362 2023年6月  
  • Kazuomi Kario, Satoshi Hoshide, Masaki Mogi
    Hypertension research : official journal of the Japanese Society of Hypertension 2023年5月15日  
  • Masaki Mogi, Satoshi Hoshide, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 46(5) 1071-1072 2023年5月  
  • Naoki Watanabe, Kenji Harada, Hisaya Kobayashi, Yasushi Imai, Saeko Yoshizawa, Koji Kawahito, Kazuomi Kario
    Circulation journal : official journal of the Japanese Circulation Society 87(5) 673-673 2023年4月25日  
  • Takafumi Okuyama, Tomoyuki Kabutoya, Yuki Gonda, Kana Kubota Kashihara, Yasushi Imai, Yuji Morisawa, Kazuomi Kario
    Internal medicine (Tokyo, Japan) 62(8) 1191-1194 2023年4月15日  
    A 23-year-old man with no significant medical history was rushed to a hospital due to transient loss of consciousness with incontinence. The patient had developed a fever after his second dose of coronavirus disease 2019 (COVID-19) vaccine, and the patient was found groaning in bed approximately 40 hours after the vaccination in the early morning. The patient was diagnosed with Brugada syndrome (BrS) based on a drug-provocation test. His father had been diagnosed with BrS and died suddenly at 51 years of age. Young adults with a family history of BrS should be cautioned about fever following COVID-19 vaccination.
  • Masaki Mogi, Satoshi Hoshide, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 2023年4月11日  
  • 芳野 真子, 今井 靖, 根岸 経太, 大木 伸一, 川人 宏次, 苅尾 七臣
    心臓 55(4) 454-462 2023年4月  
    症例は49歳女性.44歳,48歳時に急性大動脈解離を発症し,保存的加療を受けていた.X年末より肺炎,心不全を呈し,当院での管理を希望され紹介受診となった.高身長,漏斗胸,側彎といった身体的特徴,大動脈解離,大動脈基部拡大があり,典型的なマルファン症候群と診断した.重度大動脈弁閉鎖不全症(AR)とそれによる心不全を呈していた.心不全の急性期管理を行ったのち,Bentall手術,上行大動脈弓部置換を施行,心機能は正常レベルまで回復し現在まで問題なく経過している.遺伝子診断ではFBN1変異を認め,マルファン症候群に典型的なCys残基のアミノ酸置換を伴うミスセンス変異であった.マルファン症候群でARに伴う高度収縮不全・心不全を生じても適切な外科治療と薬物療法を実施することで心機能の回復を得て良好な経過をたどった本例は示唆に富むと思われ,文献的考察とともに報告する.(著者抄録)
  • Tomonori Watanabe, Hiroaki Watanabe, Hitoshi Hachiya, Masafumi Sato, Tadayuki Mitama, Takafumi Okuyama, Ayako Yokota, Masashi Kamioka, Takahiro Komori, Tomoyuki Kabutoya, Yasushi Imai, Kazuomi Kario
    Journal of cardiovascular electrophysiology 34(4) 849-859 2023年4月  
    INTRODUCTION: Beyond pulmonary vein isolation (PVI), additional therapeutic strategies for atrial fibrillation (AF) have not been established. Remodeling of the left atrium (LA) could impact AF recurrence post-PVI. We investigated the impact of unipolar voltage (UV) criteria for the LA posterior wall (LA-PW) on AF recurrence post-PVI. METHODS: We reviewed the cases of 106 AF patients (mean age 63.8 years, nonparoxysmal AF: 59%) who underwent extensive encircling PVI by radiofrequency ablation guided by a 3-dimension mapping system, investigating the impact on AF recurrence of the UV criteria of the LA. RESULTS: Out of all patients, 26 patients had AF recurrence during post-PVI follow-up [median 603 days]. They showed a higher percentage of nonparoxysmal AF (80.8 vs. 52.5%, p = .011), longer AF duration (2.9 ± 2.7 vs. 1.0 ± 1.7 years, p = .002), and larger area size of UV < 2.0 mV in LA-PW (2.8 ± 1.8 vs. 1.0 ± 1.5 cm2 , p < .001) than those without recurrence. Cox Hazard analysis for AF recurrence adjusted by age, gender, AF duration, body mass index and left atrial volume index revealed that an area size over 2.0 cm2 of UV < 2.0 mV in LA-PW (HR 6.9 [95% CI:1.3-35.5], p = .021) posed independent risks for AF recurrence post-PVI. The atrial arrhythmia-free survival rate was higher in those with no area of UV < 3.0 mV in LA-PW compared to those with a sizable area (>2.0 cm2 ) of UV < 3.0 mV and <2.0 mV (95.0% vs. 74.2% vs. 57.1%, Log-Rank: p < .001). In the AF etiology of patients with AF recurrence, 9 of 14 patients who underwent the 2nd procedure had no PV reconnection, and 8 patients required the LA-PW isolation for their non-PV AF. CONCLUSION: UV criteria of LA-PW is a useful parameter for AF-recurrence post-PVI. Lower UV in LA-PW as an indication of electrical remodeling could indicate a higher risk of AF recurrence and the need for further therapeutic strategies.
  • Satoshi Hoshide, Masaki Mogi, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 46(4) 815-816 2023年4月  
  • Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
    Hypertension research : official journal of the Japanese Society of Hypertension 46(4) 950-958 2023年4月  
    Increased blood pressure (BP) variability and the BP surge have been reported to be associated with increased cardiovascular risk independently of BP levels and can also be a trigger of cardiovascular events. There are multiple types of BP variation: beat-to-beat variations related to breathing and the autonomic nervous system, diurnal BP variation and nocturnal dipping related to sleep and physical activity over a 24-hr period, day-to-day BP variability with anomalous readings within a several-day period, visit-to-visit BP variability between outpatient visits, and seasonal variations. BP variability is also associated with the progression to hypertension from prehypertension and the progression of chronic kidney disease and cognitive impairments. Our research group proposed the "resonance hypothesis of blood pressure surge" as a new etiological hypothesis of BP variability and surges; i.e., the concept that when the time phases of surges and hypertension-inducing environmental influences coincide, resonance occurs and is amplified into a larger "dynamic surge" that triggers the onset of cardiovascular disease. New devices to assess BP variability as well as new therapeutic interventions to reduce BP variability are being developed. Although there are still issues to be addressed (including measurement accuracy), cuffless devices and information and communication technology (ICT)-based BP monitoring devices have been developed and validated. These new devices will be useful for the individualized optimal management of BP. However, evidence regarding the usefulness of therapeutic interventions to control BP variability is still lacking.
  • 横田 彩子, 甲谷 友幸, 三玉 唯由季, 奥山 貴文, 渡邉 裕昭, 上岡 正志, 渡部 智紀, 小森 孝洋, 今井 靖, 苅尾 七臣
    日本循環器学会学術集会抄録集 87回 PJ073-5 2023年3月  
  • 三玉 唯由季, 甲谷 友幸, 奥山 貴文, 渡邉 裕昭, 横田 彩子, 上岡 正志, 渡部 智紀, 小森 孝洋, 今井 靖, 苅尾 七臣
    日本循環器学会学術集会抄録集 87回 PJ113-2 2023年3月  
  • 小林 久也, 船山 大, 篠原 肇, 大場 祐輔, 小古山 由佳子, 清水 勇人, 苅尾 七臣
    日本循環器学会学術集会抄録集 87回 CROJ16-9 2023年3月  

MISC

 220
  • 石井 正将, 大塚 康弘, 池邉 壮, 中村 太志, 辻田 賢一, 藤田 英雄, 的場 哲哉, 興梠 貴英, 大場 祐輔, 甲谷 友幸, 苅尾 七臣, 清末 有宏, 水野 由子, 中山 雅晴, 宮本 恵宏, 佐藤 寿彦, 永井 良三
    日本循環器学会学術集会抄録集 88回 PJ122-2 2024年3月  
  • Masaki Mogi, Yasuhito Ikegawa, Shunsuke Haga, Satoshi Hoshide, Kazuomi Kario
    Hypertension Research 2024年  
    Hypertension, a disease whose prevalence increases with age, induces pathological conditions of ischemic vascular disorders such as cerebral infarction and myocardial infarction due to accelerated arteriosclerosis and circulatory insufficiency of small arteries and sometimes causes hemorrhagic conditions such as cerebral hemorrhage and ruptured aortic aneurysm. On the other hand, as it is said that aging starts with the blood vessels, impaired blood flow associated with vascular aging is the basis for the development of many pathological conditions, and ischemic changes in target organs associated with vascular disorders result in tissue dysfunction and degeneration, inducing organ hypofunction and dysfunction. Therefore, we hypothesized that hypertension is associated with all age-related vascular diseases, and attempted to review the relationship between hypertension and diseases for which a relationship has not been previously well reported. Following our review, we hope that a collaborative effort to unravel age-related diseases from the perspective of hypertension will be undertaken together with experts in various specialties regarding the relationship of hypertension to all pathological conditions. (Figure presented.).
  • 人見泰弘, 今井靖, 桑原政成, 牧元久樹, 興梠貴英, 相澤健一, 大場祐輔, 甲谷友幸, 苅尾七臣, 的場哲哉, 藤田英雄, 永井良三
    日本臨床薬理学会学術総会抄録集(Web) 44th 2023年  
  • Michiaki Nagai, Takeshi Fujiwara, Kazuomi Kario
    Journal of Clinical Hypertension 23(9) 1681-1683 2021年9月1日  
  • Michiaki Nagai, Kazuomi Kario
    Journal of Clinical Hypertension 23(8) 1526-1528 2021年8月1日  

共同研究・競争的資金等の研究課題

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