基本情報
研究キーワード
33経歴
5-
2006年 - 現在
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2006年 - 現在
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1998年 - 2006年
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1994年 - 1995年
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1985年
受賞
3-
2024年10月
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2003年
論文
182-
Journal of neuroendocrinology 31(3) e12700 2019年3月 査読有りOxytocin neurones in the hypothalamus are activated by stressful stimuli and food intake. The oxytocin receptor is located in various brain regions, including the sensory information-processing cerebral cortex; the cognitive information-processing prefrontal cortex; reward-related regions such as the ventral tegmental areas, nucleus accumbens and raphe nucleus; stress-related areas such as the amygdala, hippocampus, ventrolateral part of the ventromedial hypothalamus and ventrolateral periaqueductal gray; homeostasis-controlling hypothalamus; and the dorsal motor complex controlling intestinal functions. Oxytocin affects behavioural and neuroendocrine stress responses and terminates food intake by acting on the metabolic or nutritional homeostasis system, modulating emotional processing, reducing reward values of food intake, and facilitating sensory and cognitive processing via multiple brain regions. Oxytocin also plays a role in interactive actions between stress and food intake and contributes to adaptive active coping behaviours.
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Nature communications 9(1) 4604-4604 2018年11月2日 査読有り
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MOLECULAR THERAPY 26(5) 130-131 2018年5月 査読有り
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Journal of neuroendocrinology e12603 2018年4月22日 査読有り
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The journal of gene medicine 20(4) e3013 2018年4月 査読有り
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Endocrinology 159(2) 763-775 2018年2月1日 査読有り
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Molecular genetics and metabolism reports 10 67-74 2017年3月 査読有り
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Biological psychiatry 81(3) 243-251 2017年2月1日 査読有り
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JOURNAL OF NEUROENDOCRINOLOGY 28(6) 2016年6月 査読有り
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Neuroscience research 99 62-8 2015年10月 査読有り
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Neuroscience letters 600 22-7 2015年7月23日 査読有り
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Science (New York, N.Y.) 348(6232) 333-6 2015年4月17日 査読有り
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Interdisciplinary Information Sciences 21(3) 189-195 2015年 査読有りOxytocin plays an essential role in milk ejection and parturition in mammals. Oxytocin has also been shown to be involved in the control of various behaviors, including anxiety-related behaviors, food intake and affiliative behaviors.<br>We previously showed that noxious stimuli or stimuli previously paired with noxious stimuli (conditioned fear stimuli) activate hypothalamic oxytocin neurons via activation of brainstem catecholaminergic/prolactin-releasing peptide (PrRP)-positive neurons. Oxytocin neurons are activated not only by noxious stimuli but also by non-noxious touch stimuli. Social contact has been suggested to activate oxytocin neurons. Non-noxious tactile stimuli induce 50-kHz ultrasonic vocalization, an index of positive states in rats, and activate hypothalamic oxytocin neurons, suggesting that pleasant tactile stimuli activate oxytocin neurons.<br>Physiological roles of oxytocin released during noxious or non-noxious tactile stimuli remain to be clarified. Noxious stimuli increase anxiety-related behavior, while pleasant sensory stimuli have pro-social actions. We have shown that endogenous oxytocin reduces anxiety-related behaviors, induces a decrease in amounts of food intake per meal, and facilitates social recognition via distinct neural pathways. Roles of oxytocin released during sensory stimuli may be dependent upon the sensory stimuli used, and oxytocin may contribute to the prevention of overreactions to noxious stimuli or mediate pro-social or anxiolytic actions of pleasant tactile stimuli.
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Endocrinology 155(8) 2996-3004 2014年8月 査読有り
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The Journal of physiology 591(13) 3433-49 2013年7月1日 査読有り
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JOURNAL OF NEUROENDOCRINOLOGY 25(5) 455-465 2013年5月 査読有り
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Journal of child and adolescent psychopharmacology 23(2) 123-7 2013年3月 査読有り
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JOURNAL OF NEUROENDOCRINOLOGY 24(4) 629-641 2012年4月 査読有り
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JOURNAL OF NEUROENDOCRINOLOGY 24(4) 587-598 2012年4月 査読有り
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Endocrinology 152(7) 2768-74 2011年7月 査読有り
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Journal of neuroendocrinology 23(1) 20-7 2011年1月 査読有り
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The FEBS journal 277(24) 4998-5005 2010年12月 査読有り
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JOURNAL OF NEUROENDOCRINOLOGY 22(9) 987-995 2010年9月 査読有り
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PEPTIDES 31(6) 1124-1130 2010年6月 査読有り
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 396(3) 703-708 2010年6月 査読有り
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TRENDS IN ENDOCRINOLOGY AND METABOLISM 21(5) 287-293 2010年5月 査読有り
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Pathophysiology 17(2) 135-140 2010年4月 査読有り
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JOURNAL OF ENDOCRINOLOGY 204(3) 275-285 2010年3月 査読有り
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NATURE 464(7287) 413-U110 2010年3月 査読有り
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ENDOCRINE JOURNAL 57 S353-S353 2010年3月 査読有り
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JOURNAL OF NEUROENDOCRINOLOGY 22(1) 33-42 2010年1月 査読有り
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JOURNAL OF NEUROENDOCRINOLOGY 21(11) 921-934 2009年11月 査読有り
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CELL METABOLISM 10(5) 355-365 2009年11月 査読有り
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HORMONES AND BEHAVIOR 55(3) 434-441 2009年3月 査読有り
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JOURNAL OF NEUROENDOCRINOLOGY 21(3) 183-190 2009年3月 査読有り
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JOURNAL OF NEUROSCIENCE 29(7) 2259-2271 2009年2月 査読有り
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JOURNAL OF CLINICAL INVESTIGATION 118(12) 4014-4024 2008年12月 査読有り
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NEUROSCIENCE 156(3) 466-474 2008年10月 査読有り
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NEUROREPORT 19(9) 951-955 2008年6月 査読有り
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ENDOCRINOLOGY 149(3) 1295-1301 2008年3月 査読有り
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STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS 11(5) 363-369 2008年 査読有り
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ADVANCES IN VASOPRESSIN AND OXYTOCIN: FROM GENES TO BEHAVIOUR TO DISEASE 170 137-151 2008年 査読有り
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日本生理学会大会発表要旨集 2008 106-106 2008年Food intake is controlled by signals from the brainstem that mediate signals from the gut. Prolactin-releasing peptide (PrRP) neurons are localized in the brainstem. In the present study, we investigated whether food intake activates PrRP neurons. We examined expression of phospho-CREB in PrRP neurons after food intake. The percentage of phospho-CREB-positive PrRP neurons in the nucleus of tractus solitarii was increased by food intake, suggesting that food intake activates PrRP neurons in the nucleus tractus solitarii. To further study the role of endogenous PrRP in food intake, we generated PrRP-deficient mice. PrRP-deficient mice developed late onset obestity associated with metabolic disorders due to hyperphagia but not to energy expenditure, and showed an attenuated response to the peripheral satiety signal, cholecystokinin. Blockade of endogenous PrRP signaling by a central injection of monoclonal anti-PrRP neutralizing antibodies increased food intake, reflecting an increase in meal size. Furthermore, we demonstrated that leptin-induced reduction in food intake and body weight was impaired in PrRP-deficient mice. All these data suggest that PrRP relays satiety signals within the brain and that disturbance of this system can result in obesity and associated metabolic disorders. [J Physiol Sci. 2008;58 Suppl:S106]
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ANESTHESIA AND ANALGESIA 105(5) 1489-1493 2007年11月 査読有り
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PEPTIDES 28(8) 1596-1604 2007年8月 査読有り
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ENDOCRINOLOGY 148(5) 2251-2263 2007年5月 査読有り
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TRANSPLANTATION 83(10) 1365-1370 2007年5月 査読有り
MISC
165-
bioRxiv 2022年3月12日Abstract In humans, tear volume increases in emotional arousal. No studies have investigated the relationship of emotional arousal and tear volume in animals. We measured tear volume in dogs before and after reunion with their owners. Tear volume increased significantly during owner, but not familiar non-owner, reunions but not during reunions with familiar non-owners. When oxytocin instillation was applied to dogs, the tear volume increased, suggesting that oxytocin can mediate the emotion-induced tear secretion in dogs. When the photos of dog’s face in which artificial tear was applied to the dog’s eyes, the positive impression of these photo increased. These suggest that emotional tear can facilitate human-dog emotional connection.
共同研究・競争的資金等の研究課題
38-
日本学術振興会 科学研究費助成事業 基盤研究(B) 2020年4月 - 2023年3月
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日本学術振興会 科学研究費助成事業 挑戦的研究(萌芽) 2019年6月 - 2021年3月
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日本学術振興会 科学研究費助成事業 基盤研究(B) 2017年4月 - 2020年3月
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日本学術振興会 科学研究費助成事業 挑戦的研究(萌芽) 2017年6月 - 2019年3月
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日本学術振興会 科学研究費助成事業 新学術領域研究(研究領域提案型) 2015年11月 - 2018年3月