基本情報
研究キーワード
33経歴
5-
2006年 - 現在
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2006年 - 現在
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1998年 - 2006年
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1994年 - 1995年
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1985年
受賞
2-
2003年
論文
166-
NEUROSCIENCE LETTERS 136(2) 157-160 1992年3月 査読有りEffects of a dopamine D1 receptor antagonist, SCH 23390, were investigated on plasma level of vasopressin after stressful stimuli in rats. The antagonist markedly attenuated the increase in plasma level of vasopressin after electric footshocks but not after s.c. injected hypertonic saline. The antagonist, however, did not significantly change the suppressive vasopressin response to fear-related emotional stress, though the drug suppressed motor behavior of the rat during testing period. These data suggest that dopamine D1 receptors play an important role selectively in the facilitatory vasopressin response to noxious stimuli in rats.
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NEUROSCIENCE LETTERS 133(1) 133-136 1991年11月 査読有りThe possibility that arterial baroreceptors may be involved in the potentiation of vasopressin or oxytocin secretion observed after noxious stimuli was tested in male rats after sino-aortic denervation (SAD). There was no significant difference in plasma level of vasopressin or oxytocin between the SAD and the corresponding sham-operation control (SHAM) groups with or without electric shocks. An i.p. injected alpha-1-adrenergic receptor antagonist, prazosin, decreased arterial blood pressure both in the SAD and in the SHAM groups. However, the increased levels of these hormones after prazosin were significantly lower in the SAD than in the SHAM groups. Reflexly evoked tachycardia after prazosin occurred in the SHAM but not in the SAD groups. These results suggest that afferent neural signals originating from arterial baroreceptors are not involved in potentiation of vasopressin and oxytocin secretion after noxious stimuli in the rat.
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THIRD INTERNATIONAL VASOPRESSIN CONFERENCE 208 245-255 1991年 査読有り
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NEUROSCIENCE LETTERS 120(2) 187-190 1990年12月 査読有りInteractions between emotional stress due to fear and hypovolemic stimuli on vasopressin secretion were studied in rats. Intraperitoneally injected dextran did not significantly change plasma osmolality osmolality and arterial blood pressure but increased blood hemoglobin and plasma vasopressin level. An i.v. infused physiological solution reversed these changes. Emotional stress due to fear acquired by learning suppressed plasma vasopressin level in dextran-injected rats. Emotional stress due to fear produced by low-frequency footshocks also suppressed the increased plasma vasopressin level. These results suggest that emotional stress due to fear interacts with afferent neural signals originating from cardio-vascular volume receptors in the control of vasopressin secretion.
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EXPERIMENTAL BRAIN RESEARCH 81(1) 53-58 1990年 査読有り
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NEUROSCIENCE LETTERS 105(3) 312-315 1989年11月 査読有り
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JOURNAL OF NEUROENDOCRINOLOGY 1(4) 233-234 1989年 査読有り
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NEUROSCIENCE RESEARCH 6(2) 143-148 1988年12月 査読有り
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EXPERIMENTAL BRAIN RESEARCH 71(2) 291-297 1988年 査読有り
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JAPANESE JOURNAL OF PHYSIOLOGY 38(5) 741-746 1988年 査読有り
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RECENT PROGRESS IN POSTERIOR PITUITARY HORMONES 1988 797 65-72 1988年 査読有り
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BRAIN RESEARCH 410(1) 140-142 1987年4月 査読有り
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BIOCHEMISTRY 25(26) 8396-8402 1986年12月 査読有り
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JAPANESE JOURNAL OF PHYSIOLOGY 36(5) 921-933 1986年 査読有り
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JAPANESE JOURNAL OF PHYSIOLOGY 36(6) 1253-1260 1986年 査読有り
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JAPANESE JOURNAL OF PHYSIOLOGY 36(6) 1261-1266 1986年 査読有り
MISC
165-
bioRxiv 2022年3月12日Abstract In humans, tear volume increases in emotional arousal. No studies have investigated the relationship of emotional arousal and tear volume in animals. We measured tear volume in dogs before and after reunion with their owners. Tear volume increased significantly during owner, but not familiar non-owner, reunions but not during reunions with familiar non-owners. When oxytocin instillation was applied to dogs, the tear volume increased, suggesting that oxytocin can mediate the emotion-induced tear secretion in dogs. When the photos of dog’s face in which artificial tear was applied to the dog’s eyes, the positive impression of these photo increased. These suggest that emotional tear can facilitate human-dog emotional connection.
共同研究・競争的資金等の研究課題
38-
日本学術振興会 科学研究費助成事業 基盤研究(B) 2020年4月 - 2023年3月
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日本学術振興会 科学研究費助成事業 挑戦的研究(萌芽) 2019年6月 - 2021年3月
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日本学術振興会 科学研究費助成事業 基盤研究(B) 2017年4月 - 2020年3月
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日本学術振興会 科学研究費助成事業 挑戦的研究(萌芽) 2017年6月 - 2019年3月
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日本学術振興会 科学研究費助成事業 新学術領域研究(研究領域提案型) 2015年11月 - 2018年3月