研究者業績

藤田 英雄

フジタ ヒデオ  (FUJITA HIDEO)

基本情報

所属
自治医科大学 附属さいたま医療センター/ 医学部総合医学第1講座 教授
学位
医学博士(東京大学)

J-GLOBAL ID
200901000408616016
researchmap会員ID
6000003282

研究キーワード

 1

論文

 302
  • Masataka Sata, Hiroshi Yamashita, Seiryo Sugiura, Hideo Fujita, Shin-ichi Momomura, Takashi Serizawa
    Pflügers Archiv European Journal of Physiology 429(3) 443-445 1995年1月  査読有り
    We attempted to introduce calcium regulation into in vitro motility assay. Cardiac thin filament was reconstituted from actin and tropomyosin-troponin complex purified from rat myocardium separately. Double staining of the filaments showed tropomyosin-troponin complex was integrated along actin filaments homogeneously. The reconstituted thin filaments were made to slide on cardiac myosin fixed on a glass coverslip in the presence of MgATP while varying free Ca2+ concentration of the medium ([Ca2+]). Filaments showed only Brownian motion when [Ca2+] was below 10-6.4 M. However, filaments slid at a constant velocity when [Ca2+] exceeded 10-6.4 M, showing that the sliding was regulated in an on-off manner. The threshold [Ca2+] increased to 10-5.0 M under acidic conditions, indicating a decrease in Ca2+ sensitivity of the contractile proteins. Simple actin filaments slid at a constant velocity independently of [Ca2+], demonstrating that the regulatory proteins were responsible for this on-off manner regulation. This new assay technique may be a powerful tool to directly evaluate the Ca2+ sensitivity of the contractile apparatus and to investigate how cardiac contraction is regulated by Ca2+. © 1995 Springer-Verlag.
  • 石坂 信和, 渡辺 昌文, 藤田 英雄
    Japanese Journal of Interventional Cardiology 8(3) 264-270 1993年6月  
    1) TECは先端のカッターを回転させて粥腫を破砕し,破砕片を吸引回収する新しいカテーテルである。TECを用いた冠動脈形成術において,末梢塞栓を認めず,血栓除去効果は十分期待できる。2) TEC通過成功病変は21病変中8病変,TECのみで残存狭窄度50%以下となった病変は12病変であり,TECのみでは,粥腫除去効果は不十分である。3)バックアップの弱い9Fのガイドカテーテルとハイトルクフロッピーガイドワイヤーを使用した症例に,TEC通過不成功例があり,病変部のTEC通過にはガイドカテーテルの強い補助と専用ガイドワイヤーの使用が必要と考えられた。4)極端な屈曲を有する病変を除外することによりTECは比較的安全に施行し得た。5) TECとバルーンを使用した冠動脈形成術の3ヵ月後の再狭窄率は29%であった。翌日造影時の狭窄度は,3ヵ月後再狭窄のpredictorであった

MISC

 107
  • Yohei Nomura, Naoyuki Kimura, Akinori Aomatsu, Akio Matsuda, Yusuke Imamura, Yosuke Taniguchi, Daijiro Hori, Manabu Shiraishi, Kenichi Sakakura, Hiroshi Wada, Hideo Fujita, Yoshiyuki Morishita, Koichi Yuri, Kenji Matsumoto, Atsushi Yamaguchi
    CIRCULATION 140 2019年11月  
    0
  • 的場 哲哉, 興梠 貴英, 藤田 英雄, 苅尾 七臣, 中山 雅晴, 清末 有宏, 辻田 賢一, 宮本 恵宏, 中島 直樹, 筒井 裕之, 永井 良三
    医療情報学連合大会論文集 39回 155-155 2019年11月  
  • Kenichi Sakakura, Kei Yamamoto, Yousuke Taniguchi, Yoshimasa Tsurumaki, Shin-ichi Momomura, Hideo Fujita
    Cardiovascular Revascularization Medicine 19(3) 286-291 2018年4月1日  
    Intravascular ultrasound (IVUS) is mainly used in PCI to treat complex lesions, such as left main bifurcation, chronic total occlusion and calcified lesions. Although IVUS yields useful information such as the presence of napkin-ring calcification, the role of IVUS in rotational atherectomy (RA) is not fully appreciated. Recently, since the deliverability and crossability of IVUS catheters have improved, IVUS should be attempted before RA. Even if the IVUS catheter cannot cross the lesion, IVUS provides information just proximal to the target lesion, which would be useful in the selection of the appropriate guidewire and burr size. IVUS can be repeated following RA, which may influence the decision to continue RA with larger burrs. Circumferential calcification is a good indication for RA, since RA can create a calcium crack that facilitates balloon dilatation. However, if the distribution of calcification is not circumferential, the indication for RA can more safely be determined based on IVUS images than angiographic information alone. Because RA burrs usually follow the route taken by the IVUS catheter, the positional relationship between the IVUS imaging core and calcification would be similar to that between the RA burrs and calcification. The relationship between the RA burrs and distribution of calcification is discussed in this review.
  • Yusuke Adachi, Kenichi Sakakura, Tomohisa Okochi, Takaaki Mase, Mitsunari Matsumoto, Hiroshi Wada, Hideo Fujita, Shin-Ichi Momomura
    International heart journal 59(2) 451-454 2018年3月30日  
    A 32-year-old man with a history of bronchial asthma was referred for low back pain and bilateral femur pain. Vascular sonography revealed bilateral deep vein thrombosis (DVT) from the femoral veins to the popliteal veins. Computed tomography revealed hypoplasia of the inferior vena cava (IVC) and dilated lumbar veins, ascending lumbar veins, and azygos vein as collaterals. There was no evidence of malignant neoplasm. The results of the thrombophilia tests were within normal limits. Hypoplasia of the IVC is a rare cause of DVT. This anomaly should be considered as a cause of bilateral and proximal DVT, in particular, in young patients without major risk factors.
  • Kenichi Sakakura, Yousuke Taniguchi, Takunori Tsukui, Kei Yamamoto, Shin-ichi Momomura, Hideo Fujita
    JACC-CARDIOVASCULAR INTERVENTIONS 10(24) E227-E229 2017年12月  

共同研究・競争的資金等の研究課題

 3