基本情報
- 所属
- 自治医科大学 附属さいたま医療センター/ 医学部総合医学第1講座 教授
- 学位
- 医学博士(東京大学)
- J-GLOBAL ID
- 200901000408616016
- researchmap会員ID
- 6000003282
研究キーワード
1研究分野
1論文
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Cardiovascular intervention and therapeutics 2025年2月28日
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Cardiovascular intervention and therapeutics 2025年2月22日The clinical outcomes of percutaneous coronary intervention (PCI) in patients with dialysis are still worse compared with those without dialysis. Among patients with dialysis, those who started dialysis due to diabetic nephropathy (DMN) may have a worse prognosis than those who started dialysis due to non-DMN. This retrospective study aimed to compare the clinical outcomes in dialysis patients who underwent PCI between with and without long-term dialysis due to DMN. We included 303 dialysis patients with PCI. The length of dialysis at the time of PCI was used to stratify the study patients. Patients with DMN and the length of dialysis ≥ 3 years were defined as the long-DMN group (n = 117), and the others were defined as the other group (n = 186). The primary endpoint was the incidence of major adverse cardiac events (MACE), which was defined as a composite of all-cause death, non-fatal myocardial infarction, re-admission for heart failure, and ischemia-driven target vessel revascularization. A total of 165 MACE were observed with the median follow-up of 568 days. The Kaplan-Meier curves showed that MACE was more frequently observed in the long-DMN group than in the other group (p = 0.005). In the multivariate Cox hazard model, long-DMN was significantly associated with MACE (hazard ratio 1.483, 95% confidence interval 1.075-2.046, p = 0.016) after controlling for multiple confounding factors. Among patients with dialysis, the combination of DMN and a long history of dialysis is closely associated with poor clinical outcomes. These patients should be carefully followed up by both cardiologists and nephrologists.
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Cardiovascular intervention and therapeutics 2025年2月3日Percutaneous coronary intervention has been developed for patients with coronary artery disease. Calcified lesions are recognized as an unsolved issue where many clinical devices have evolved and some disappeared. Understanding intracoronary imaging of the calcified lesions can help operators to make decisions during the procedure. There are several potential stories of progression of calcification, although a precise mechanism of progression of calcification remains unknown. In the process of a large calcification, it is histologically believed that lipid is replaced by calcification. This process can be observed by intracoronary imaging devices, i.e., intravascular ultrasound and optical coherence tomography. Calcified nodule is a unique type of calcifications. Among the calcified lesions, especially calcified nodule has serious clinical outcomes such as target lesion revascularization (TLR) with stent under-expansion. Additionally, in-stent calcified nodule is a distinctive type of restenosis pattern after stenting to calcified nodule, leading to malignant cycle of repeated TLR. Recently, calcified nodule is divided into two types based on the surface irregularity: (1) eruptive and (2) non-eruptive calcified nodule. Eruptive calcified nodule has higher rate of target vessel revascularization than non-eruptive calcified nodule despite greater stent expansion in eruptive calcified nodule. It is thought that there are differences of component such as the amount of fibrin and the size of calcific nodules between both, although it is common for both to include calcific nodules and fibrin. Histopathological understanding calcified nodule can be helpful to choose the treatment devices during the procedure in the area where there is no correct answer.
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Cardiovascular intervention and therapeutics 2025年1月24日
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European Heart Journal - Digital Health 6(2) 209-217 2025年1月16日Abstract Aims Delayed diagnosis of pulmonary hypertension (PH) is a known cause of poor patient prognosis. We aimed to develop an artificial intelligence (AI) model, using ensemble learning method to detect PH using electrocardiography (ECG), chest X-ray (CXR), and brain natriuretic peptide (BNP), facilitating accurate detection and prompting further examinations. Methods and results We developed a convolutional neural network model using ECG data to predict PH, labelled by ECG from seven institutions. Logistic regression was used for the BNP prediction model. We referenced a CXR deep learning model using ResNet18. Outputs from each of the three models were integrated into a three-layer fully connected multimodal model. Ten cardiologists participated in an interpretation test, detecting PH from patients’ ECG, CXR, and BNP data both with and without the ensemble learning model. The area under the receiver operating characteristic curves of the ECG, CXR, BNP, and ensemble learning model were 0.818 [95% confidence interval (CI), 0.808–0.828], 0.823 (95% CI, 0.780–0.866), 0.724 (95% CI, 0.668–0.780), and 0.872 (95% CI, 0.829–0.915). Cardiologists’ average accuracy rates were 65.0 ± 4.7% for test without AI model and 74.0 ± 2.7% for test with AI model, a statistically significant improvement (P < 0.01). Conclusion Our ensemble learning model improved doctors’ accuracy in detecting PH from ECG, CXR, and BNP examinations. This suggests that earlier and more accurate PH diagnosis is possible, potentially improving patient prognosis.
MISC
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CIRCULATION 140 2019年11月0
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Journal of Thoracic Disease 10 S3176-S3181 2018年9月1日
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Cardiovascular Revascularization Medicine 19(3) 286-291 2018年4月1日Intravascular ultrasound (IVUS) is mainly used in PCI to treat complex lesions, such as left main bifurcation, chronic total occlusion and calcified lesions. Although IVUS yields useful information such as the presence of napkin-ring calcification, the role of IVUS in rotational atherectomy (RA) is not fully appreciated. Recently, since the deliverability and crossability of IVUS catheters have improved, IVUS should be attempted before RA. Even if the IVUS catheter cannot cross the lesion, IVUS provides information just proximal to the target lesion, which would be useful in the selection of the appropriate guidewire and burr size. IVUS can be repeated following RA, which may influence the decision to continue RA with larger burrs. Circumferential calcification is a good indication for RA, since RA can create a calcium crack that facilitates balloon dilatation. However, if the distribution of calcification is not circumferential, the indication for RA can more safely be determined based on IVUS images than angiographic information alone. Because RA burrs usually follow the route taken by the IVUS catheter, the positional relationship between the IVUS imaging core and calcification would be similar to that between the RA burrs and calcification. The relationship between the RA burrs and distribution of calcification is discussed in this review.
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International heart journal 59(2) 451-454 2018年3月30日A 32-year-old man with a history of bronchial asthma was referred for low back pain and bilateral femur pain. Vascular sonography revealed bilateral deep vein thrombosis (DVT) from the femoral veins to the popliteal veins. Computed tomography revealed hypoplasia of the inferior vena cava (IVC) and dilated lumbar veins, ascending lumbar veins, and azygos vein as collaterals. There was no evidence of malignant neoplasm. The results of the thrombophilia tests were within normal limits. Hypoplasia of the IVC is a rare cause of DVT. This anomaly should be considered as a cause of bilateral and proximal DVT, in particular, in young patients without major risk factors.
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Successful Removal of an Entrapped Rotational Atherectomy Burr Using a Soft Guide Extension CatheterJACC-CARDIOVASCULAR INTERVENTIONS 10(24) E227-E229 2017年12月
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Cardiovascular Revascularization Medicine 18(4) 295-298 2017年6月1日Side branch occlusion, which was one of the common complications in percutaneous coronary interventions, was closely associated with cardiac death and myocardial infarction. Clinical guidelines also support the importance of preservation of physiologic blood flow in SB during PCI to bifurcation lesions. In order to avoid side branch occlusion during stent implantation, we often performed the jailed wire technique, in which a conventional guide wire was inserted to the side branch before stent implantation to the main vessel. However, the jailed wire technique could not always prevent side branch occlusion. In this case report, we described a case of 72-year-old male suffering from angina pectoris. Coronary angiography revealed the diffuse calcified stenosis in the proximal and middle of left anterior descending coronary artery, and the large diagonal branch originated from the middle of the stenosis. To prevent side branch occlusion, we performed a novel side branch protection technique by using the Corsair microcatheter (Asahi Intecc, Nagoya, Japan). In this case report, we illustrated this “Jailed Corsair technique”, and discussed the advantage compared to other side branch protection techniques such as the jailed balloon technique.
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JOURNAL OF CARDIAC FAILURE 22(9) S225-S225 2016年9月
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CIRCULATION JOURNAL 80(8) 1700-1701 2016年8月
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DIABETES RESEARCH AND CLINICAL PRACTICE 118 154-155 2016年8月
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JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 27(7) 881-883 2016年7月
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JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 27(5) 621-622 2016年5月
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CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY 9(1) 2016年1月
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INTERNATIONAL JOURNAL OF CARDIOLOGY 199 38-39 2015年11月
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JOURNAL OF CARDIAC FAILURE 21(10) S190-S190 2015年10月
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Case reports in cardiology 2015 407059-407059 2015年We present a case of a patient who needed rapid switch from intra-aortic balloon pumping (IABP) to percutaneous cardiopulmonary support (PCPS)/venoarterial extracorporeal membrane oxygenation. It is difficult to switch from IABP to PCPS, because 0.035-inch guidewires cannot pass the IABP guidewire lumen (0.025-inch compatible), and the IABP sheath needs to be removed together with the IABP catheter. First, a 0.025-inch guidewire was inserted into the IABP wire lumen, and then the IABP catheter together with the 8 Fr IABP sheath was removed, leaving the 0.025-inch guidewire in place. We used the Perclose ProGlide for safe and rapid exchange of the 0.025-inch guidewire for a 0.035-inch guidewire. This allowed insertion of a PCPS cannula and the prompt initiation of PCPS.
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レジデントノート 16(13) 2486-2495 2014年12月
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ACTA OPHTHALMOLOGICA 92(6) E492-E493 2014年9月
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内分泌・糖尿病・代謝内科 38(6) 490-495 2014年6月
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ICUとCCU : 集中治療医学 36(10) 886-890 2012年10月
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Journal of Diabetes Science and Technology 6(4) 983-985 2012年
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IEEJ Transactions on Sensors and Micromachines 132(11) 381-386 2012年Very recently, mobile devices as intelligent data terminals have become widely popular in the world, which are expected to contribute to medical/health information and communication technology (ICT). As it is recognized to be critical to share medical/health information between patients and healthcare providers electronically, a variety of electronic health record (EHR) and personal health record (PHR) systems have been developed. Furthermore, advances in mobile and cloud computing technologies nowadays enable us to transmit information anywhere at any time, and provide better environment for EHR/PHR. It will be of great importance to promote research and development of a novel mobile/cloud system to integrate dispersedly stored pieces of patients' healthcare information into virtually combined one. Those records include not only static previously collected medical records, but also currently occurring dynamic data of patients such as vital signs, adherence to medication, and emergency medical records. We particularly focus on better clinical outcome, as well as efficacy, safety, and security matters achieved by those innovative systems in the various medical/health fields. Through development of new sensor devices and ICT, a systematic methodology would be strongly required to establish virtual space of ubiquitous health information. © 2012 The Institute of Electrical Engineers of Japan.
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日本遠隔医療学会雑誌 7(2) 144-146 2011年10月
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INTERNATIONAL HEART JOURNAL 52(5) 327-330 2011年9月Interrupted inferior vena cava (IVC) with azygos continuation is a rare congenital anomaly, and is frequently associated with other cardiovascular malformations and situs anomalies, such as left isomerism. These patients usually develop deep vein thrombosis (DVT), and asymptomatic patients above 60 years of age are very rare. Here we report a case of interrupted IVC which we diagnosed in a 72-year-old woman. She was admitted to our hospital suffering from heart failure and supraventricular tachycardia. Echocardiography detected secundum atrial septal defect (ASD). An abnormal paravertebral pleural line on the chest X-rays indicated the existence of venous anomaly. Anatomical images obtained by Multidetector Computed Tomography (MDCT) helped us to successfully perform right heart catheterization procedures through azygos continuation including blood sampling from pulmonary veins. Even in elderly patients, a careful examination of chest X-rays can indicate undiagnosed venous anomalies; thus, it is critically important before planning surgical or interventional procedures. (Int Heart J 2011; 52: 327-330)
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CIRCULATION JOURNAL 75(4) 773-774 2011年4月
共同研究・競争的資金等の研究課題
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