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  2. 西村 渉

西村 渉

ニシムラ ワタル  (Wataru Nishimura)

基本情報

所属
自治医科大学医学部 解剖学講座解剖学部門 教授
学位
博士（医学）(岡山大学)
ORCID ID
 https://orcid.org/0000-0002-8068-1277
J-GLOBAL ID
200901002936688765
researchmap会員ID
1000365863
外部リンク

研究キーワード

 10

研究分野

 7

経歴

 8
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学歴

 2

委員歴

 17
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受賞

 11
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論文

 46
  • Takao Nammo, Nobuaki Funahashi, Haruhide Udagawa, Junji Kozawa, Kenta Nakano, Yukiko Shimizu, Tadashi Okamura, Miho Kawaguchi, Takashi Uebanso, Wataru Nishimura, Masaki Hiramoto, Iichiro Shimomura, Kazuki Yasuda
    Life science alliance 7(8) 2024年8月  
    A lack of social relationships is increasingly recognized as a type 2 diabetes (T2D) risk. To investigate the underlying mechanism, we used male KK mice, an inbred strain with spontaneous diabetes. Given the association between living alone and T2D risk in humans, we divided the non-diabetic mice into singly housed (KK-SH) and group-housed control mice. Around the onset of diabetes in KK-SH mice, we compared H3K27ac ChIP-Seq with RNA-Seq using pancreatic islets derived from each experimental group, revealing a positive correlation between single-housing-induced changes in H3K27ac and gene expression levels. In particular, single-housing-induced H3K27ac decreases revealed a significant association with islet cell functions and GWAS loci for T2D and related diseases, with significant enrichment of binding motifs for transcription factors representative of human diabetes. Although these H3K27ac regions were preferentially localized to a polymorphic genomic background, SNVs and indels did not cause sequence disruption of enriched transcription factor motifs in most of these elements. These results suggest alternative roles of genetic variants in environment-dependent epigenomic changes and provide insights into the complex mode of disease inheritance.
  • Aiko Oka, Masahiro Takahashi, Wataru Nishimura, Shogo Oyamada, Shinichiro Oka, Satoshi Iwasaki, Kengo Kanai, Mitsuhiro Okano
    The journal of allergy and clinical immunology. Global 3(2) 100237-100237 2024年5月  
    The objective of this study was to investigate the levels of gene expression in the middle ear mucosa of 2 patients diagnosed with eosinophilic otitis media. One patient with severe hearing loss showed high expression levels of genes encoding IL-5 and IL-33 receptors.
  • Haruhide Udagawa, Nobuaki Funahashi, Wataru Nishimura, Takashi Uebanso, Miho Kawaguchi, Riku Asahi, Shigeru Nakajima, Takao Nammo, Masaki Hiramoto, Kazuki Yasuda
    Scientific reports 13(1) 17958-17958 2023年10月20日  
    The mechanisms of impaired glucose-induced insulin secretion from the pancreatic β-cells in obesity have not yet been completely elucidated. Here, we aimed to assess the effects of adipocyte-derived factors on the functioning of pancreatic β-cells. We prepared a conditioned medium using 3T3-L1 cell culture supernatant collected at day eight (D8CM) and then exposed the rat pancreatic β-cell line, INS-1D. We found that D8CM suppressed insulin secretion in INS-1D cells due to reduced intracellular calcium levels. This was mediated by the induction of a negative regulator of insulin secretion-NECAB1. LC-MS/MS analysis results revealed that D8CM possessed steroid hormones (cortisol, corticosterone, and cortisone). INS-1D cell exposure to cortisol or corticosterone increased Necab1 mRNA expression and significantly reduced insulin secretion. The increased expression of Necab1 and reduced insulin secretion effects from exposure to these hormones were completely abolished by inhibition of the glucocorticoid receptor (GR). NECAB1 expression was also increased in the pancreatic islets of db/db mice. We demonstrated that the upregulation of NECAB1 was dependent on GR activation, and that binding of the GR to the upstream regions of Necab1 was essential for this effect. NECAB1 may play a novel role in the adipoinsular axis and could be potentially involved in the pathophysiology of obesity-related diabetes mellitus.
  • Aiko Oka, Kengo Kanai, Takaya Higaki, Seiichiro Makihara, Yohei Noda, Shin Kariya, Mizuo Ando, Wataru Nishimura, Mitsuhiro Okano
    The journal of allergy and clinical immunology. Global 2(3) 100123-100123 2023年8月  
    BACKGROUND: Chronic rhinosinusitis (CRS) can be divided into endotypes by functional or pathophysiologic findings. OBJECTIVE: The aim of this study was to analyze the expression of cytokines, prostaglandin (PG) synthases, and their receptors related to the pathogenesis of CRS, especially those contributing to nasal polyp (NP) formation. METHODS: NPs and uncinate tissue (UT) samples were collected from 90 patients who underwent endoscopic sinus surgery. They included 75 patients with CRS (including 45 with eosinophilic CRS [eCRS] and 30 with non-eCRS) and 15 patients without CRS. A total of 30 genes were selected for our original DNA array plate to analyze the levels of expression of 10 cytokines (IFN-γ, IL-4, IL-5, IL-10, IL-13, IL-17A, IL-22, IL-25, IL-33, and TSLP), 4 prostaglandin synthases (prostaglandin D2 [PGD2] synthase, prostaglandin E2 synthase, COX-1, and COX-2), and their 16 receptors. Clustering analysis was performed according to the expression results, and clinical findings of patients from each cluster were investigated. RESULTS: The samples could be divided into 3 clusters. Cluster 1 showed elevated levels of expression of IL4, IL5, IL13, TSLP, IL1RL1 (ST2 [an IL-33 receptor]), HPGDS, and GPR44 (CRTH2, a PGD2 receptor); cluster 2 showed elevated levels of expression of IL17A and PTGES; and cluster 3 showed an elevated level of expression of IL25. Regarding clinical features, the main characteristics of each cluster were as follows: NPs from patients with eCRS for cluster 1, NPs and/or UT samples from patients with non-eCRS for cluster 2, and UTs from patients with non-CRS for cluster 3. CONCLUSION: The results suggest that there are associations between type 2 inflammation/PGD2 and eCRS and also between type 3 inflammation/prostaglandin E2 and non-eCRS.
  • Wataru Nishimura, Hiroaki Iwasa, Munkhtuya Tumurkhuu
    International Journal of Molecular Science 23(9) 4478 2022年4月  査読有り招待有り筆頭著者責任著者
もっとみる

MISC

 139
  • 宇田川 陽秀, 川口 美穂, 平本 正樹, 西村 渉, 鏑木 康志, 安田 和基
    糖尿病 53(Suppl.1) S-203 2010年4月  
  • Ilham El Khattabi, Takuma Kondo, Wataru Nishimura, Susan Bonner-Weir, Gordon Weir, Arun Sharma
    DIABETES 58 A427-A427 2009年6月  
  • Wataru Nishimura, Susan Bonner-Weir, Kirstine Juhl, Arun Sharma
    DIABETES 58 A408-A409 2009年6月  
  • Wan-Chun Li, Annemarie Kloosterman, Wataru Nishimura, Elena Toschi, Arun Sharma, Susan Bonnerweir
    DIABETES 56 A421-A421 2007年6月  
  • Wataru Nishimura, Sheldon Rowan, Therese Salameh, Richard Maas, Susan Bonner-Weir, Susan Sell, Arun Sharma
    DIABETES 56 A48-A48 2007年6月  
  • Kondo Takuma, Ilham El Khattabi, Wataru Nishimura, Susan Bonner-Weir, Gordon Weir, Arun Sharma
    DIABETES 56 A444-A445 2007年6月  
  • Angela Koh, Elena Toschi, Tandy Aye, Wataru Nishimura, Igor Leykin, Aron Sharma, Susan Bonner-Weir
    DIABETES 56 A429-A429 2007年6月  
  • 西村 渉, Sharma Arun
    再生医療 6(1) 56-63,7〜9 2007年2月  
  • Takuma Kondo, Therese Salameh, Samit Shah, Ilham Elkhattabi, Wataru Nishimura, Arun Sharma
    DIABETES 55 A367-A367 2006年6月  
  • Wataru Nishimura, Takuma Kondo, Ilham El Khattabi, Rikke Dodge, I-Cheng Ho, Susan-Bonner Weir, Arun. J. Sharma
    DIABETES 55 A362-A362 2006年6月  
  • 堀見 忠司, 近藤 慶二, 吉田 貢, 寺田 紘一, 徳岡 裕文, 久 明史, 松岡 潔, 三原 康生, 杉山 章, 津野 憲雄, 松野 剛, 石川 忠則, 武田 功, 笹岡 和雄, 市川 純一, 稲垣 優, 岡崎 泰長, 岡林 孝弘, 公家 健志, 長田 裕典, 西岡 豊, 濱田 円, 渋谷 祐一, 志摩 泰生, 尾崎 和七, 藤澤 憲司, 石井 龍宏, 伊藤 充矢, 桜間 一史, 西江 学, 内多 嘉具, 依光 幸夫, 横田 哲夫, 高崎 元宏, 堤 克嘉, 江盛 康之, 高松 正宏, 山本 良一, 谷岡 洋亮, 重戸 伸幸, 清水 慎一, 久礼 三子雄, 宇田 憲司, 森 一正, 佐野 由文, 根津 眞司, 尾形 雅彦, 高野 篤, 花田 備文, 秋森 豊一, 神原 浩, 藤村 治彦, 間島 國博, 松田 浩明, 森 淳, 小倉 薫, 岡本 健, 小橋 研太, 西村 渉, 水嶋 秀, 宮内 章充, 松岡 尚則, 中川 仁志, 尾崎 信三, 中城 徹, 永野 克二, 野口 洋文, 小高 雅人, 寺石 文則, 森 直樹, 久保 慎一郎, 甫喜本 憲弘, 小坂 芳和, 森 佐和, 宗石 秀典, 田中 優治, 森下 延真, 江口 泰右, 宮川 美子, 上岡 樹生, 上野 邦夫, 畠山 暢生, 福田 綾子, 澤田 妙子, 井上 敬太, 斉藤 華子, 伊藤 友佳, 岸本 英樹
    高知市医師会医学雑誌 10(1) 131-137 2005年3月  
    高知県立中央病院において1986～2003年までに手術した初発胃癌3056例(男性1944例,女性1112例)の臨床的検討を報告した.30歳未満が14例(0.5%:男性6例,女性8例),90歳以上が8例(0.3%:男性3例,女性5例)であった.術式は開腹による幽門側胃切除術1820例(59.6%),同胃全摘術748例(24.5%),内視鏡的胃粘膜切除術259例(8.5%),腹腔鏡・腹腔鏡補助幽門側胃切除術87例(2.8%)などで,切除不能胃癌は82例(2.7%)であった.胃癌手術以外の付加手術は794例(26.4%)で行い,胆嚢摘出術348例(全胃癌手術中11.4%),膵体尾部-脾合併切除155例(5.1%),脾臓摘出術70例(2.3%),結腸切除術59例(1.9%)などであった.最近5ヵ年間の566例の累積生存率は,5年生存率が85.1%,Stage別の5年生存率はStage Ia 95.9%,Ib 92.1%,II 84.9%,IIIa 67.2%,IIIbとIVに5年生存はなく,4年生存率ではそれぞれ44.0%,6.5%であった
  • 堀見 忠司, 近藤 慶二, 吉田 貢, 寺田 紘一, 徳岡 裕文, 久 明史, 松岡 潔, 三原 康生, 杉山 章, 津野 憲雄, 松野 剛, 石川 忠則, 武田 功, 笹岡 和雄, 市川 純一, 稲垣 優, 岡崎 泰長, 岡林 孝弘, 公家 健志, 長田 裕典, 西岡 豊, 濱田 円, 渋谷 祐一, 志摩 泰生, 尾崎 和七, 藤澤 憲司, 石井 龍宏, 伊藤 充矢, 桜間 一史, 西江 学, 内多 嘉具, 依光 幸夫, 横田 哲夫, 高崎 元宏, 堤 克嘉, 江盛 康之, 高松 正宏, 山本 良一, 谷岡 洋亮, 重戸 伸幸, 清水 慎一, 久礼 三子雄, 宇田 憲司, 森 一正, 佐野 由文, 根津 眞司, 尾形 雅彦, 高野 篤, 花田 備文, 秋森 豊一, 神原 浩, 藤村 治彦, 間島 國博, 松田 浩明, 森 淳, 小倉 薫, 岡本 健, 小橋 研太, 西村 渉, 水嶋 秀, 宮内 章充, 松岡 尚則, 中川 仁志, 尾崎 信三, 中城 徹, 永野 克二, 野口 洋文, 小高 雅人, 寺石 文則, 森 直樹, 久保 慎一郎, 甫喜本 憲弘, 小坂 芳和, 森 佐和, 宗石 秀典, 田中 優治, 森下 延真, 江口 泰右, 宮川 美子, 上岡 樹生, 上野 邦夫, 畠山 暢生, 福田 綾子, 澤田 妙子, 井上 敬太, 斉藤 華子, 伊藤 友佳, 岸本 英樹
    高知市医師会医学雑誌 10(1) 138-141 2005年3月  
    高知県立中央病院において1986～2003年までに手術した残胃癌63例(男性49例,女性14例)の臨床的検討を報告した.残胃癌63例は同時期に手術を行った初発胃癌3056例の2.0%であった.年齢別では40歳代2例,50歳代9例,60歳代20例,70歳代27例,80歳代5例であった.術式は残胃全摘術57例(90.5%),内視鏡的胃粘膜切除術2例(3.2%)で,切除不能が4例(6.3%)あった.付加手術は47例(74.6%)で行い,胆嚢摘出術11例(全残胃癌手術の17.5%),膵体尾部-脾合併切除術11例(17.5%),結腸切除術7例(11.1%),脾摘出術6例(9.5%),肝切除術6例(9.5%)などであった.術後経過不明1例を除く62例の累積生存率は,1年65.2%,2年54.7%,3年40.5%,4年24.9%,5年21.8%で,切除できた60例では1年67.6%,2年56.6%,3年42%,4年25.8%,5年22.6%と若干良好であったが,いずれも初発胃癌より生存率は低かった
  • T Kondo, T Salameh, S Shah, W Nishimura, A Sharma
    DIABETES 54 A401-A402 2005年  
  • W Nishimura, T Salameh, R Dodge, T Kondo, IC Ho, S Bonner-Weir, A Sharma
    DIABETES 54 A393-A394 2005年  
  • W Nishimura, T Salameh, T Kondo, A Sharma
    DIABETES 53 A40-A40 2004年6月  
  • M Deguchi, T Iizuka, Y Hata, W Nishimura, K Hirao, Yao, I, H Kawabe, Y Takai
    JOURNAL OF BIOLOGICAL CHEMISTRY 277(38) 35778-35778 2002年9月  
  • Yao, I, J Iida, W Nishimura, Y Hata
    JOURNAL OF NEUROSCIENCE 22(13) 5354-5364 2002年7月  
    Brain-enriched guanylate kinase-associated protein (BEGAIN) interacts with postsynaptic density (PSD)-95/synapse-associated protein (SAP) 90. In immunohistochemistry and immunocytochemistry, BEGAIN was detected in nuclei and at synapses in neurons. Nuclear localization was also confirmed through subcellular fractionation. BEGAIN was localized exclusively in nuclei when expressed in epithelial cells. These findings led us to analyze the mechanism to determine the subcellular localization of BEGAIN in neurons. Green fluorescent protein (GFP)-tagged BEGAIN appeared first in nuclei and subsequently accumulated at dendrites. Approximately 75 and 90% of GFP-BEGAIN clusters were colocalized with synaptophysin and PSD-95/SAP90, respectively. GFP-protein containing only the N-terminal region also formed foci in nuclei and clusters at dendrites. The N-terminal BEGAIN was not precisely targeted to synapses, although it was partially localized at synapses, possibly through dimer formation with endogenous BEGAIN. The truncated form of PSD-95/SAP90 containing the guanylate kinase domain blocked synaptic targeting of BEGAIN but did not affect cluster formation at dendrites. NMDA receptor antagonists blocked localization of GFP-BEGAIN at synapses but did not affect recruitment to dendrites. These results suggest that BEGAIN is recruited to dendrites by the N-terminal region independently of NMDA receptor activity and that synaptic targeting of BEGAIN depends on NMDA receptor activity and may be mediated by interaction with PSD-95/SAP90.
  • J Iida, W Nishimura, Yao, I, Y Hata
    EUROPEAN JOURNAL OF NEUROSCIENCE 15(9) 1493-1498 2002年5月  
    Membrane-associated guanylate kinase-interacting protein (MAGUIN) has been identified as a protein binding postsynaptic density (PSD)-95 and synaptic scaffolding molecule (S-SCAM). MAGUIN has one sterile alpha motif, one conserved region in connector enhancer of ksr (Cnk) (CRIC), one PSD-95/Dlg-A/ZO-1 (PDZ) and one pleckstrin homology (PH) domain. There are two isoforms, MAGUIN-1 and -2. MAGUIN-1 binds the PDZ domains of PSD-95 and S-SCAM by the C-terminus, whereas MAGUIN-2 does not bind to PSD-95 or S-SCAM. Here, we have determined that MAGUIN-2 is also localized at synapses and that the synaptic localization of MAGUIN depends on the pleckstrin homology domain. The overexpressed C-terminal PDZ-binding region inhibits the synaptic targeting of PSD-95. Furthermore, the synaptic targeting of MAGUIN does not require N-methyl-d-aspartate (NMDA) receptor activity. These findings suggest that MAGUIN-1 and -2 are recruited to synapses by the PH domain and that MAGUIN-1 subsequently interacts with PSD-95 at synapses.
  • W Nishimura, Yao, I, J Iida, N Tanaka, Y Hata
    JOURNAL OF NEUROSCIENCE 22(3) 757-765 2002年2月  
    Synaptic scaffolding molecule (S-SCAM) is a synaptic membrane-associated guanylate kinase with inverted domain organization (MAGI) that interacts with NMDA receptor subunits and neuroligin. In epithelial cells, the non-neuronal isoform of S-SCAM (MAGI-1) is localized at tight or adherens junctions. Recent studies have revealed that the polarized targeting of MAGI-1 to the lateral membrane is mediated by its C-terminal region and that MAGI-1 interacts with beta-catenin in epithelial cells. In this article, we report that S-SCAM interacts with beta-catenin in neurons. beta-Catenin is coimmunoprecipitated with S-SCAM from rat brain. Both S-SCAM and beta-catenin are localized at synapses and are partially colocalized. The C-terminal region of S-SCAM binds to the C-terminal region of beta-catenin. We have tested how the interaction between S-SCAM and beta-catenin plays a role in the synaptic targeting of S-SCAM and beta-catenin. S-SCAM is targeted to synapses via the C-terminal postsynaptic density-95/Dlg-A/ZO-1 (PDZ) domain. beta-Catenin is targeted to synapses with armadillo repeats. The over-expressed C-terminal region of beta-catenin blocks the synaptic targeting of S-SCAM. The overexpressed C-terminal region of S-SCAM is partially targeted to synapses and forms a small number of clusters. In the presence of overexpressed beta-catenin, the C-terminal region of S-SCAM forms more clusters at synapses. These data suggest that the synaptic targeting of S-SCAM is mediated by the interaction with beta-catenin.
  • W Nishimura, Y Naomoto, K Hamaya, S Toda, K Miyagi, N Tanaka
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 16(5) 586-590 2001年5月  
    Basaloid-squamous cell carcinoma of the esophagus (BSCC) is an extremely rare tumor. Histologically, this tumor should be differentiated from adenoid cystic carcinoma (ACC) and small cell undifferentiated carcinoma (SCUC). Biologically, this tumor is very aggressive, with a propensity for distant metastasis. We report a 64-year-old male with esophageal BSCC. The patient complained of dysphagia and was found to have a torous lesion in the esophagus on radiological examination. Upper gastrointestinal fiberscopy showed a localized ulcerative type tumor, which was diagnosed as squamous cell carcinoma (SCC) on biopsy. Surgery resulted in curative resection. A histological examination of the resected tumor showed features of BSCC. Immunohistochemical examination demonstrated AE3/1- and CAM 5.2-positive tumor cells, and laminin-positive cells in the periphery of the nests. These data were useful in differentiating this tumor from ACC and SCUC. Six months after surgery, the patient developed hepatic metastases, which were successfully treated by regional chemotherapy via the hepatic artery by using fluorouracil. The patient is currently being followed up at the outpatient clinic and shows no signs of any recurrence. (C) 2001 Blackwell Science Asia Pty Ltd.
  • W Nishimura, T Iizuka, S Hirabayashi, N Tanaka, Y Hata
    JOURNAL OF CELLULAR PHYSIOLOGY 185(3) 358-365 2000年12月  
    Brain-specific angiogenesis inhibitor (BAI)-associated protein (BAP)1 (also called membrane-associated guanylate kinase [MAGI]-1) is composed of six PSD-95/Dlg-A/ZO-1 (PDZ) domains, two WW domains, and one guanylate kinase (CK) domain. We previously reported that BAP1 is localized at tight junctions in Madine Darby canine kidney (MDCK) cells and intestinal epithelial cells. Here, we have determined the localization of BAP1 in normal rat kidney (NRK) cells that do not form light junctions. BAP1 was colocalized with E-cadherin along the lateral membrane, suggesting its localization at adherens junctions. Green fluorescent protein (GFP)-BAP1 was distributed in the cytosol in separate NRK cells, and accumulated to the cell-cell contacts when NRK cells have contact with each other. The GFP-BAP1 mutant containing either the first PDZ and CK domains or the WW and second PDZ domains was localized in the cytosol and the nucleus. The GFP-BAP1 mutant containing the second to fourth PDZ domains was distributed in the cytosol. The construct containing the fifth and sixth PDZ domains was localized at the cell-cell contacts along the lateral membrane and slightly in the nucleus, whereas the construct lacking the fifth and sixth PDZ domains was localized in the cytosol and in the nucleus. BAP1 was tyrosine-phosphorylated in vivo, but the tyrosine phosphorylation of BAP1 was not correlated with its localization. These results suggest that the signal in the carboxyl-terminal PDZ domains functions dominantly in vivo to target BAP1 to the lateral membrane, although potential nuclear localization signals exist in the N-terminal region of BAP1. J. Cell. Physiol. 185:358-365, 2000. (C) 2000 Wiiey-Liss, Inc.
  • 西村 渉, 田中紀章, 畑裕
    実験医学 18 2541-2545 2000年11月  
  • M Deguchi, T Iizuka, Y Hata, W Nishimura, K Hirao, Yao, I, H Kawabe, Y Takai
    JOURNAL OF BIOLOGICAL CHEMISTRY 275(38) 29875-29880 2000年9月  
    A neural plakophilin-related armadillo repeat protein (NPRAP)/delta-catenin interacts with one of Alzheimer disease-related gene products, presenilin 1. We have previously reported the interaction of NPRAP/delta-catenin with synaptic scaffolding molecule, which is involved in the assembly of synaptic components. NPRAP/delta-catenin also interacts with E-cadherin and beta-catenin and is implicated in the organization of cell-cell junctions. p0071, a ubiquitous isoform of NPRAP/delta-catenin, is localized at desmosomes in HeLa and A431 cells and at adherens junctions in Madin-Darby bovine kidney cells. We have identified here a novel protein interacting with NPRAP/ delta-catenin and p0071 and named this protein plakophilin-related armadillo repeat protein-interacting PSD-95/ Dlg-A/ZO-1 (PDZ) protein (PAPIN). PAPIN has six PDZ domains and binds to NPRAP/delta-catenin and p0071 via the second PDZ domain. PAPIN and p0071 are ubiquitously expressed in various tissues and are localized at cell-cell junctions in normal rat kidney cells and bronchial epithelial cells. PAPIN may be a scaffolding protein connecting components of epithelial junctions with p0071.
  • Experimental Medicine (Japanese) 18 (18), 2541-2545 2000年  
  • 西村 渉, 戸田佐登志, 宮木功次
    日本臨床外科学会雑誌 60(6) 1528-1532 1999年  
    症例は81歳女性.食欲不振を主訴に当院入院,精査にて食道癌および胃体上部に巨大な粘膜下腫瘍を認め, 6月17日食道亜全摘・胃上部切除R1,胸腔内食道胃吻合を施行した.胃粘膜下腫瘍は8.0×7.8×4.8cmで,病理組織所見では扁平上皮癌であり,食道癌の胃壁内転移と考えられた.原発性食道癌取扱い規約に基づく手術所見はImEi, A0 N(-), M0. Pl0. Stage Iであった.術後2年2カ月現在再発兆候を認めない.食道癌の胃壁内転移の頻度は1.0～4.7%と少ないが,原発巣に比べ胃壁内転移巣の方が大きかったり,急速に増大するものがしばしば認められる.食道癌の診療に際しては,たとえ術前N(-), A0の症例であっても胃病変の詳細な観察が必要である.
  • 西村 渉, 戸田佐登志, 宮木功
    胆と膵 20(9) 799-802 1999年  
  • 西村 渉, 戸田 佐登志, 宮木 功次
    日本臨床外科学会雑誌 60 (6), 1528-1532(6) 1528-1532 1999年  
    症例は81歳女性.食欲不振を主訴に当院入院,精査にて食道癌および胃体上部に巨大な粘膜下腫瘍を認め, 6月17日食道亜全摘・胃上部切除R1,胸腔内食道胃吻合を施行した.胃粘膜下腫瘍は8.0×7.8×4.8cmで,病理組織所見では扁平上皮癌であり,食道癌の胃壁内転移と考えられた.原発性食道癌取扱い規約に基づく手術所見はImEi, A0 N(-), M0. Pl0. Stage Iであった.術後2年2カ月現在再発兆候を認めない.食道癌の胃壁内転移の頻度は1.0～4.7%と少ないが,原発巣に比べ胃壁内転移巣の方が大きかったり,急速に増大するものがしばしば認められる.食道癌の診療に際しては,たとえ術前N(-), A0の症例であっても胃病変の詳細な観察が必要である.
  • Journal of Biliary Tract and Pancreas (Japanese) 20 (9), 799-802 1999年  
  • 移植 32 (2), 67-72 1997年  
  • 西村 渉, 堀見忠司, 長田裕典, 宮内章充, 松岡尚則, 西村誠明, 三宅 晋, 森田荘二郎
    移植 32(3) 174-179 1997年  
  • W Nishimura, T Horimi, S Miyake, M Nishimura, F Kuwao, N Mizobuchi, M Yamamoto
    JAPANESE JOURNAL OF TRANSPLANTATION 32(2) 67-72 1997年  
    A positive crossmatch, especially in T-cell reactivity, against donor cells is considered a contraindication to renal transplantation. Generally, a crossmatch is positive when the reading score is 4 (killed lymphocytes are over 20%). Double filtration plasmapheresis (DFPP) is useful for turning a positive crossmatch in patients into a negative one. Among 110 recipients with living related donors, 26 patients who had a positive crossmatch (including 12 cases of T-cell warm reactivity and 4 cases of B-cell warm reactivity) before but not at the time of transplantation after DFPP, have successfully accepted grafts in living related renal transplantation. Graft survival was observed retrospectively in these 26 patients for the comparison with 84 patients with a negative cross match. Of these 110 patients, 47 underwent donor specific blood transfusion (DST) and then DFPP. All patients were immune-suppressed with cyclosporine, azathioprine and methyl-predonisolone prior to the procedures. There was no difference between graft survival rate oi patients with and without a previous positive cross match. We conclude that a living related renal transplantation in patients with previous positive crossmatch, after DFPP, can be safely undertaken.
  • W Nishimura, T Horimi, H Nagata, A Miyauchi, N Matsuoka, S Nishimura, S Miyake, S Morita
    JAPANESE JOURNAL OF TRANSPLANTATION 32(3) 174-179 1997年  
    A 44 year-old woman received a living related renal transplant. On postoperative day 12, the serum creatinine level increased, and a graft biopsy showed acute rejection. Pulse therapy with methylprednisolone was given, but she developed high fever, severe upper abdominal pain and anemia on postoperative day 18 Abdominal ultrasonography and computed tomography showed swelling of the gallbladder and a tumor-like lesion in the liver bed. On the diagnosis of a tumor in the gallbladder with bleeding, we performed cholecystectomy on postoperative day 23. The gallbladder was filled with blood, and had a small polyp and a stone. Microscopic findings showed acute cholecystitis and a hemorrhagic polyp. In the mucosal cytologic examination with Papanicolaou stain, a cytomegalic inclusion body was observed. After cholecystectomy the function of the graft has been maintained satisfactorily. To date, 68 cases of hemorrhage from the gallbladder have been reported, but among them there is only one case after renal transplant.
  • T Horimi, M Takasaki, A Toki, W Nishimura, S Morita
    HEPATO-GASTROENTEROLOGY 43(11) 1225-1229 1996年9月  
    Background/Aims: Hormone therapy by tamoxifen was performed on patients with adenocarcinoma of the pancreas and the effect of tamoxifen on their survival rate was evaluated inpatients with resected pancreatic adenocarcinoma (n=65). Material and Methods: Tamoxifen. lugs administered once daily (at 20mg) in addition, to immunochemotherapy (Tegaful, Mitomycin, Krestin or OK-432). Results: A remarkably beneficial effect of tamoxifen was found when compared with non-tamoxifen group (p<0.01). When the location of the pancreatic carcinoma was considered, the survival rate of the tamoxifen group with adenocarcinoma in the head and in, also the body/tail of the pancreas revealed the same statistically significant difference (p<0.01) individually. Regarding curability by surgery, the beneficial effect of tamoxifen was observed even in the survival rate of patients who had received noncurative surgery. Furthermore, the remarkable effect of tamoxifen was revealed in the male group, whose one-year survival rate for resected carcinoma in the head of the pancreas was 85.6% (n=16) as when. compared to 19.1% of non-tamoxifen group (n=15) and also in the female group whose one-year survival rate was 53.8% (n=1.3) compared with 21.4% of non-tamoxifen group (n=7) (p<0.01). Conclusion: With these data, we can see that the adjuvant therapy of tamoxifen in carcinoma of the pancreas confers a significant benefit to those patients who have received a surgical resection and reduction in the volume of the carcinoma in the pancreas.
  • 西村 渉, 堀見忠司, 公家健志, 中川仁志, 坂本芳也
    日本臨床外科医学会雑誌 57(3) 643-648 1996年  
    症例は33歳女性.妊娠7カ月時点より腹痛・膨満感・便秘を認めたが,妊娠悪阻として経過観察されていた.妊娠34週6日に出産後も腹痛・腹満感が続くため当院受診し,腹部膨満,肝腫大,腹水を指摘された.入院後の諸検査でS状結腸癌による腸閉塞および多発性肝転移と診断し,分娩から10日後にS状結腸切除術を施行した.手術所見はS状結腸癌で, circ 3型3.0×3.0cm, SE, P0, H3, M(-), N2(+), Stage IV, 病理所見は高分化型腺癌で, s, INFβ, ly3, v3, n2(+), ow(-), aw(-), ew(-) であった. H3に対しreservoirを留置し術後化学療法を行ったが,術後3カ月で肝転移の増大による肝不全のため死亡した.妊娠合併大腸癌はきわめて稀で,本邦報告例は28例にすぎない.その予後は一般に不良であり,妊婦でも本症の疑いがあれば便潜血,超音波など胎児に影響のない検査を積極的に進める必要があるものと考えられた.
  • 西村 渉, 堀見 忠司, 公家 健志, 中川 仁志, 坂本 芳也
    日本臨床外科医学会雑誌 57 (3), 643-648(3) 643-648 1996年  
    症例は33歳女性.妊娠7カ月時点より腹痛・膨満感・便秘を認めたが,妊娠悪阻として経過観察されていた.妊娠34週6日に出産後も腹痛・腹満感が続くため当院受診し,腹部膨満,肝腫大,腹水を指摘された.入院後の諸検査でS状結腸癌による腸閉塞および多発性肝転移と診断し,分娩から10日後にS状結腸切除術を施行した.手術所見はS状結腸癌で, circ 3型3.0×3.0cm, SE, P0, H3, M(-), N2(+), Stage IV, 病理所見は高分化型腺癌で, s, INFβ, ly3, v3, n2(+), ow(-), aw(-), ew(-) であった. H3に対しreservoirを留置し術後化学療法を行ったが,術後3カ月で肝転移の増大による肝不全のため死亡した.妊娠合併大腸癌はきわめて稀で,本邦報告例は28例にすぎない.その予後は一般に不良であり,妊婦でも本症の疑いがあれば便潜血,超音波など胎児に影響のない検査を積極的に進める必要があるものと考えられた.
  • 堀見忠司, 公家健志, 西村 渉, 田中 拓, 高崎元宏, 依光幸夫, 森田荘二郎
    高知県立中央病院医学雑誌 21 45-47 1994年  
  • 西村 渉, 堀見忠司, 石川忠則, 川上雅史, 依光聖一, 高橋 功, 森田荘二郎
    高知県立中央病院医学雑誌 21(2) 75-80 1994年  
  • Kochi Journal of Medicine (Japanese) 21 (2), 45-47 1994年  
  • Kochi Journal of medicine (Japanese) 21 (2), 75-80 1994年  

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