Yusuke Sakurai, Kensuke Yokoyama, Atsushi Kanno, Akitsugu Tanaka, Eriko Ikeda, Kozue Ando, Masanobu Taguchi, Hideki Sasanuma, Naohiro Sata, Naoki Sano, Noriyoshi Fukushima, Hironori Yamamoto
Internal medicine (Tokyo, Japan) 2024年10月25日
A 50-year-old man was diagnosed with type 1 autoimmune pancreatitis (AIP) following endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and a histopathological examination. After six months of untreated follow-up, the serum IgG4 level decreased, and the diffuse pancreatic enlargement improved; however, a pancreatic head mass became apparent. EUS-FNA of this mass revealed pancreatic ductal adenocarcinoma (PDAC) with IgG4-positive plasma cells. In addition, the resected specimen revealed PDAC, without any features of AIP. After pancreatoduodenectomy, AIP did not recur. The development of AIP in this case could be related to paraneoplastic syndrome.
