医学部 麻酔科学・集中治療医学講座

今長谷 尚史

イマハセ ヒサシ  (Hisashi Imahase)

基本情報

所属
自治医科大学 医学部麻酔科学・集中治療医学講座(集中治療医学部門) 助教
東京大学 大学院医学系研究科社会医学専攻医療倫理学講座 医学博士課程
学位
M.D.(2008年3月 九州大学医学部医学科)
MPH(2018年3月 東京大学大学院医学系研究科)

研究者番号
10724057
J-GLOBAL ID
202001009330787540
researchmap会員ID
R000006893

経歴

 2

論文

 20
  • 今長谷 尚史, 方山 真朱, 塩塚 潤二, 鈴木 賀代, 小山 寛介, 藤内 研, 新里 祐太朗, 讃井 將満
    日本救急医学会雑誌 35(11) 781-781 2024年11月  
  • 小古山 由佳子, 小山 寛介, 新里 祐太朗, 今長谷 尚史, 藤内 研, 佐多 奈歩, 方山 真朱, 讃井 將満
    日本集中治療医学会雑誌 31(Suppl.1) S1006-S1006 2024年9月  
  • Ken Tonai, Shinshu Katayama, Kansuke Koyama, Hisashi Imahase, Shin Nunomiya
    Journal of anesthesia, analgesia and critical care 4(1) 23-23 2024年4月3日  
    BACKGROUND: Sepsis-3 emphasizes the recognition of sepsis-induced cellular metabolic abnormalities, and utilizes serum lactate level as a biomarker of cellular metabolic abnormalities. Magnesium plays an important role as a cofactor in glucose metabolism, although it is not well known that magnesium deficiency causes elevated serum lactate levels. Additionally, it remains unclear how magnesium status affects the role of serum lactate levels as a marker of metabolic abnormalities in sepsis. Thus, this study aimed to investigate the association between serum magnesium and lactate levels in patients with sepsis and explore this relationship from the perspectives of time course and circulatory abnormalities. METHODS: This retrospective observational study of adult patients with sepsis was performed at the 16-bed intensive care unit of Jichi Medical University Hospital between June 2011 and December 2017. The relationship between serum magnesium and lactate levels for 5 days from intensive care unit admission was investigated along the time course. Multivariate logistic regression analysis was performed to evaluate the association between serum magnesium and lactate levels during intensive care unit admission. RESULTS: Among 759 patients included, 105 had hypomagnesemia (magnesium level < 1.6 mg/dL), 558 had normal serum magnesium levels (1.6-2.4 mg/dL), and 96 had hypermagnesemia (magnesium level > 2.4 mg/dL) at intensive care unit admission. From intensive care unit admission to day 5, the hypomagnesemia group had higher serum lactate levels and a higher frequency of lactic acidosis than the normal magnesium level and hypermagnesemia groups (70% vs. 51.6% vs. 50%; P < 0.001). Hypomagnesemia at intensive care unit admission was independently associated with lactic acidosis, i.e., lactic acid level > 2 mmol/L (odds ratio, 2.76; 95% confidence interval, 1.60-4.76; P < 0.001). CONCLUSIONS: Hypomagnesemia was associated with serum lactate levels in the early and post-resuscitation phases of sepsis. Further studies are needed to elucidate whether the magnesium status is associated with sepsis-induced cellular and metabolic abnormalities.
  • 今長谷 尚史, 方山 真朱
    日本救急医学会雑誌 34(12) 725-725 2023年12月  
  • 今長谷 尚史, 方山 真朱, 布宮 伸, 藤内 研, 小山 寛介, 三須 侑子, 岡田 和之, 古内 三基子
    日本集中治療医学会雑誌 30(Suppl.1) S433-S433 2023年6月  

MISC

 149

書籍等出版物

 1

所属学協会

 2

共同研究・競争的資金等の研究課題

 1