附属さいたま医療センター 周産期母子医療センター 新生児部門

池田 太郎

イケダ タロウ  (Taro Ikeda)

基本情報

所属
自治医科大学 附属さいたま医療センター周産期母子医療センター周産期科新生児部門/総合医学第二講座 教授
学位
医学博士(日本大学)
医科学修士(日本大学)

研究者番号
00318396
J-GLOBAL ID
200901087227924264
researchmap会員ID
1000286170

学歴

 1

主要な論文

 335
  • Takashi Hosokawa, Noriyoshi Konuma, Taro Ikeda, Makoto Hashimoto, Hide Kaneda, Kensuke Ohashi, Taro Matsumoto, Tsugumichi Koshinaga
    JOURNAL OF PEDIATRIC SURGERY 50(8) 1352-1358 2015年8月  査読有り
    Background/purpose: Mainstreammodels for anal sphincter injury use large animals. We developed a simple and stable anal sphincter injury model in a small animal (i.e., rats) to obtain manometry measurements by using a miniaturized probe and applying cardiotoxin. Methods: The histological structure of the anal canal was evaluated by using manometry in normal rats (n = 40). We damaged the internal and external anal sphincters by locally administering snake poison (cardiotoxin; 20 uM, 100 mu L 8 points). We evaluated the anal canal function through manometry measurements (n = 5) and examined the histology using hematoxylin-eosin staining (at each time point, n = 3; total n = 15). Results: The manometry parameters and structure of the anal canal of normal rats were similar to those of humans, because rats have resting pressure, rectoanal reflex in the manometry, and an external and internal anal sphincter. After inducing injury, the following findings were observed: rhythmic wave loss and a remarkable reduction in the anal sphincter resting pressure; and local bleeding and advanced infiltration of the inflammatory cells (day 1) and the loss of muscle fibers (day 3). Conclusion: This new rat model will contribute to increasing the knowledge on the anal canal. (C) 2015 Elsevier Inc. All rights reserved.

MISC

 112

書籍等出版物

 5

講演・口頭発表等

 66