基本情報
- 所属
- 自治医科大学 医学部薬理学講座臨床薬理学部門 教授医学部内科学講座循環器内科学部門 教授(兼)
- 学位
- 医学博士(東京大学)
- J-GLOBAL ID
- 201401001007364738
- researchmap会員ID
- B000238134
- 外部リンク
研究キーワード
6研究分野
1経歴
5-
2023年9月 - 現在
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2023年9月 - 現在
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2017年 - 現在
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2013年11月 - 2017年3月
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2012年3月 - 2013年10月
学歴
2-
1997年4月 - 2001年3月
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1988年4月 - 1994年3月
論文
177-
IJC Heart & Vasculature 101430-101430 2024年5月
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Scientific reports 14(1) 7874-7874 2024年4月3日
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Journal of arrhythmia 40(2) 363-373 2024年4月BACKGROUND: The precise details of atrial activation around the triangle of Koch (ToK) remain unknown. We evaluated the relationship between the atrial-activation pattern around the ToK and success sites for slow-pathway (SP) modification ablation in slow-fast atrioventricular reentrant tachycardia (AVNRT). METHODS: Thirty patients with slow-fast AVNRT who underwent successful ablation were enrolled. Atrial activation around the ToK during sinus rhythm was investigated using ultra-high-density mapping pre-ablation. The relationships among features of atrial-activation pattern and success sites were examined. RESULTS: Of 30 patients (22 cryoablation; 8 radiofrequency ablation), 26 patients had a collision site of two wavefronts of delayed atrial activation within ToK, indicating a success site. The activation-search function of Lumipoint software, which highlights only atrial activation with a spatiotemporal consistency, showed non-highlighted area on the tricuspid-annulus side of ToK. In 23 of the patients, a spiky potential was recorded at that collision site outside the Lumipoint-highlighted area. Fifteen cryoablation patients with a success site coincident with a collision site outside the Lumipoint-highlighted area had significantly more frequent disappearances of SP after initial cryoablation (46.7% vs. 0%, p = .029), fewer cryoablations (3.7 ± 1.8 vs. 5.3 ± 1.3, p = .045), and shorter procedure times (170 ± 57 vs. 228 ± 91 min, p = .082) compared to the seven cryoablation patients without such sites. Four patients had transient AV block by ablation inside the Lumipoint-highlighted area with fractionated signals, but no patient developed permanent AV block or recurrence post-procedure (median follow-up: 375 days). CONCLUSIONS: SP modification ablation at the collision site of atrial activation of the tricuspid-annulus side along with a spiky potential could provide a better outcome.
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Hypertension research : official journal of the Japanese Society of Hypertension 2024年3月26日Lack of the typical nocturnal blood pressure (BP) fall, i.e non-dipper, has been known as a cardiovascular risk. However, the influence of non-dipper on atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI) has been unclear. We investigated the clinical impact of non-dipping as evaluated by 24-hour ambulatory BP monitoring on the long-term outcome of AF recurrence post-PVI in 76 AF patients with a history of increased BP. The PVI procedure was successful in all 76 patients (mean age, 66±9years; antihypertensive medication, 89%; non-paroxysmal AF, 24%). Twenty patients had AF recurrence during a median follow-up of 1138 days. There was no difference in BP levels between the AF recurrence and non-recurrence groups (average 24 h systolic BP:126 ± 17 vs.125 ± 14 mmHg; P = 0.84). On the other hand, the patients with non-dipper had a higher AF recurrence than those with dipper (38.9% vs.15.0%; P = 0.018). In Cox hazard analysis adjusted by age, non-paroxysmal AF and average 24-hr systolic BP level, the non-dipper was an independent predictor of AF recurrence (HR 2.78 [95%CI:1.05-7.34], P = 0.039). Non-dipper patients had a larger left atrial (LA) volume index than the dipper patients (45.9 ± 17.3 vs.38.3 ± 10.2 ml/m2, P = 0.037). Among the 58 patients who underwent high-density voltage mapping in LA, 11 patients had a low-voltage area (LVA) defined as an area with a bipolar voltage < 0.5 mV. However, there was no association of LVA with non-dipper or dipper (22.2% vs.16.1%, P = 0.555). Non-dipper is an independent predictor of AF recurrence post-PVI. Management of abnormal diurnal BP variation post-PVI may be important.
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Pacing and clinical electrophysiology : PACE 47(1) 127-130 2024年1月BACKGROUND: Using third-party resources to manage remote monitoring (RM) data from implantable cardiac electronic devices (CIEDs) can assist in device clinic workflows. However, each hospital-acquired data is not used for further analysis as big data. METHODS AND RESULTS: We developed a real-time and automatically centralized system of CIED information from multiple hospitals. If the extensive data-based analysis suggests individual problems, it can be returned to each hospital. To show its feasibility, we prospectively analyzed data from six hospitals. For example, unexpected abnormal battery levels were easily illustrated without recall information. CONCLUSIONS: The centralized RM system could be a new platform that promotes the utilization of device data as big data, and that information could be used for each patient's practice.
MISC
224-
Circulation journal : official journal of the Japanese Circulation Society 66 386-386 2002年3月31日
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Circulation journal : official journal of the Japanese Circulation Society 66 283-283 2002年3月31日
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Circulation journal : official journal of the Japanese Circulation Society 66 437-437 2002年3月31日
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Circulation journal : official journal of the Japanese Circulation Society 66 431-431 2002年3月31日
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Circulation journal : official journal of the Japanese Circulation Society 66 787-787 2002年3月31日
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Circulation journal : official journal of the Japanese Circulation Society 66 586-586 2002年3月31日
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TAF-1 is a transcriptional cofactor that represses activation by the transcription factor IKLF/BTEB2Circulation journal : official journal of the Japanese Circulation Society 66 464-464 2002年3月31日
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Circulation journal : official journal of the Japanese Circulation Society 66 263-263 2002年3月31日
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Circulation journal : official journal of the Japanese Circulation Society 66 263-263 2002年3月31日
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Circulation journal : official journal of the Japanese Circulation Society 66 265-265 2002年3月31日
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Circulation journal : official journal of the Japanese Circulation Society 66 220-220 2002年3月31日
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Circulation journal : official journal of the Japanese Circulation Society 66 169-169 2002年3月31日
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THROMBOSIS AND HAEMOSTASIS 85(2) 226-230 2001年2月The platelet-collagen receptor, glycoprotein Ia/IIa (integrin alpha (2)beta (1)) plays a fundamental role in the adhesion of platelets to fibrillar collagen, an event leading to platelet activation and thrombus formation and contributing to the pathogenesis of thrombotic disease. Further, glyco protein Ia/IIa receptor density and function may be associated with two linked and silent polymorphisms (C-807/T and (873)G/A) within the glycoprotein Ia gene. We tested the extent to which these polymorphisms serve as genetic markers of myocardial infarction in a Japanese population. A case-control study was carried out using 210 Japanese myocardial infarction patients and 420 age- and sex-matched controls. Genotyping was accomplished using PCR followed by melting curve analysis with specific fluorescent hybridization probes. The (CC)-C-807. CT, TT genotypes linked perfectly to the (873)GG, GA, AA genotypes, respectively. Allele frequencies of the T-807 ((873)A) variant were similar in the control and patient groups (0.373 vs. 0.352). The T-807 and (873)A variants of platelet glycoprotein la gene are common and in a perfect linkage in the Japanese population, but it appears unlikely that the T-807 ((873)A) variant represents a useful marker of increased risk for myocardial infarction.
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The Journal of biological chemistry 275(47) 36991-8 2000年11月24日Ca(2+), which enters cardiac myocytes through voltage-dependent Ca(2+) channels during excitation, is extruded from myocytes primarily by the Na(+)/Ca(2+) exchanger (NCX1) during relaxation. The increase in intracellular Ca(2+) concentration in myocytes by digitalis treatment and after ischemia/reperfusion is also thought to result from the reverse mode of the Na(+)/Ca(2+) exchange mechanism. However, the precise roles of the NCX1 are still unclear because of the lack of its specific inhibitors. We generated Ncx1-deficient mice by gene targeting to determine the in vivo function of the exchanger. Homozygous Ncx1-deficient mice died between embryonic days 9 and 10. Their hearts did not beat, and cardiac myocytes showed apoptosis. No forward mode or reverse mode of the Na(+)/Ca(2+) exchange activity was detected in null mutant hearts. The Na(+)-dependent Ca(2+) exchange activity as well as protein content of NCX1 were decreased by approximately 50% in the heart, kidney, aorta, and smooth muscle cells of the heterozygous mice, and tension development of the aortic ring in Na(+)-free solution was markedly impaired in heterozygous mice. These findings suggest that NCX1 is required for heartbeats and survival of cardiac myocytes in embryos and plays critical roles in Na(+)-dependent Ca(2+) handling in the heart and aorta.
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CIRCULATION 102(18) 183-183 2000年10月
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THROMBOSIS AND HAEMOSTASIS 84(1) 137-137 2000年7月
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CIRCULATION 98(17) 604-605 1998年10月
書籍等出版物
7共同研究・競争的資金等の研究課題
13-
日本学術振興会 科学研究費助成事業 2022年4月 - 2025年3月
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日本学術振興会 科学研究費助成事業 2022年4月 - 2025年3月
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日本学術振興会 科学研究費助成事業 2020年4月 - 2025年3月
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日本学術振興会 科学研究費助成事業 2020年4月 - 2025年3月
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日本学術振興会 科学研究費助成事業 2020年7月 - 2023年3月