医学部 内科学講座 血液学部門

山本 千裕

ヤマモト チヒロ  (Yamamoto Chihiro)

基本情報

所属
自治医科大学 医学部内科学講座 血液学部門 講師

通称等の別名
Sakurai Chihiro
J-GLOBAL ID
201501017106920717
researchmap会員ID
B000248147

主要な論文

 67
  • Chihiro Sakurai, Kazuteru Ohashi, Kyogo Sakaguchi, Tsunekazu Hishima, Noriko Kamata, Hideki Akiyama, Hisashi Sakamaki
    INTERNATIONAL JOURNAL OF HEMATOLOGY 90(4) 532-536 2009年11月  査読有り
    We report the first case of Mikulicz's disease (MD) occurring 2 years after autologous peripheral blood stem cell transplantation (PBSCT) for multiple myeloma (MM). A 70-year-old man developed bilateral enlargement of parotid and submandibular glands. The patient had previously received 2 courses of autologous PBSCT for IgG-kappa type MM, and had been stable for 2 years. This salivary gland enlargement was initially felt to represent a recurrence of MM, since along with gland swelling, IgG was also elevated. However, repeated biopsy of the left submandibular gland revealed chronic sclerosing sialadenitis rather than plasmacytoma. Results of salivary gland scintigraphy, serological testing, and absence of sicca symptoms also supported the diagnosis of MD. Concurrently, the patient developed severe thrombocytopenia (0.8 x 10(4)/mu l). Bone marrow biopsy showed abundant megakaryocytes, suggesting enhanced platelet destruction. After high-dose steroid and immunoglobulin therapy, the platelet count gradually returned to normal with complete resolution of the salivary gland enlargement. No apparent signs of MM recurrence were documented during these clinical events.

MISC

 14

共同研究・競争的資金等の研究課題

 1