Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), statins, which are used to prevent cardiovascular diseases, are associated with a modest increase in the risk of new-onset diabetes. To investigate the role of HMGCR in the developmen...
Shota Okabe   Yuki Takayanagi   Masahide Yoshida   Tatsushi Onaka   
Scientific reports 10(1) 9135-9135 2020年6月 [査読有り]
Gentle tactile stimuli have been shown to play an important role in the establishment and maintenance of affiliative social interactions. Oxytocin has also been shown to have similar actions. We investigated the effects of gentle stroking on affil...
Yoshida M   Takayanagi Y   Ichino-Yamashita A   Sato K   Sugimoto Y   Kimura T   Nishimori K   
Journal of neuroendocrinology 31(3) e12700 2019年3月 [査読有り]
Oxytocin neurones in the hypothalamus are activated by stressful stimuli and food intake. The oxytocin receptor is located in various brain regions, including the sensory information-processing cerebral cortex; the cognitive information-processing...
Social stress has deteriorating effects on various psychiatric diseases. In animal models, exposure to socially dominant conspecifics (i.e., social defeat stress) evokes a species-specific defeat posture via unknown mechanisms. Oxytocin neurons ha...
Brain and nerve = Shinkei kenkyu no shinpo 75(11) 1205-1209 2023年11月
Resilience is a term that describes the capacity of coping with and recovering from stress and adversity. In terms of the concept of allostasis, resilience is the ability to appropriately regulate allostasis, efficiently terminate the allostatic r...