研究者氏名	長嶋茂雄
	ナガシマシゲオ
URL	http://kaken.nii.ac.jp/d/r/60433116.ja.html
所属	自治医科大学
部署	医学部感染・免疫学講座　ウイルス学部門
職名	准教授
J-Global ID	201401008778902426

研究キーワード

Tsg101 ,E型肝炎ウイルス ,ESCRT機構 ,放出 ,MVB経路 ,粒子形成 ,分子疫学 ,B群 ,ロタウイルス ,MRSA ,生理学 ,浸淫状況 ,PVL ,新種 ,プロテオーム ,スタフィロコアグラーゼ ,黄色ブドウ球菌 ,成人 ,熱帯地域 ,感染培養系 ,アジア ,多剤排出蛋白 ,下痢症 ,感染性cDNAクローン ,ゲノム変異 ,下痢 ,PSAPモチーフ ,腸球菌

研究分野

ライフサイエンス / ウイルス学 /
ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含む /
ライフサイエンス / 細胞生物学 /
ライフサイエンス / 分子生物学 /

経歴

2013年

自治医科大学医学部講師

論文

<3 456 7 >

The spontaneous clearance of hepatitis E virus (HEV) and emergence of HEV antibodies in a transfusion-transmitted chronic hepatitis E case after completion of chemotherapy for acute myeloid leukemia

Hiroshi Okano Tatsunori Nakano Ryugo Ito Ami Tanaka Yuji Hoshi Keiji Matsubayashi Hiroki Asakawa Kenji Nose Satomi Tsuruga Tomomasa Tochio Hiroaki Kumazawa Yoshiaki Isono Hiroki Tanaka Shimpei Matsusaki Tomohiro Sase Tomonori Saito Katsumi Mukai Akira Nishimura Keiki Kawakami Shigeo Nagashima Masaharu Takahashi Hiroaki Okamoto

Clinical Journal of Gastroenterology 13(2) 252-259 2020年4月

A 64-year-old woman was infected with hepatitis E virus (HEV) during chemotherapy for leukemia. By retrospective analyses of stored serum from the blood products and the patient, the source of the infection was determined to be platelet concentrat...

Multivesicular body sorting and the exosomal pathway are required for the release of rat hepatitis E virus from infected cells.

Putu Prathiwi Primadharsini Shigeo Nagashima Masaharu Takahashi Tominari Kobayashi Takashi Nishiyama Tsutomu Nishizawa Jiro Yasuda Mulyanto Hiroaki Okamoto

Virus research 278 197868-197868 2020年3月 [査読有り]

Recent reports have shown that rat hepatitis E virus (HEV) is capable of infecting humans. We also successfully propagated rat HEV into human PLC/PRF/5 cells, raising the possibility of a similar mechanism shared by human HEV and rat HEV. Rat HEV ...

A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis in Heart and Kidney Transplant Recipients in Japan.

Yohei Owada Yukio Oshiro Yuki Inagaki Hiroshi Harada Nobuhiro Fujiyama Naoki Kawagishi Takashi Yagisawa Joichi Usui Naotake Akutsu Yoshihiro Itabashi Kazuhide Saito Yoshihiko Watarai Naotsugu Ichimaru Ryoichi Imamura Miyaji Kyakuno Kentaro Ide Yuichi Shibuya Yasuhiro Okabe Minoru Ono Konosuke Sasaki Akira Shiose Kazumasa Yamagishi Hiroshi Ohnishi Shigeo Nagashima Masaharu Takahashi Kenji Yuzawa Hiroaki Okamoto Nobuhiro Ohkohchi

Transplantation 104(2) 437-444 2020年2月 [査読有り]

BACKGROUND: Recently, chronic hepatitis E has been reported in solid organ transplant (SOT) recipients in European countries. Previously, we clarified the prevalence of hepatitis E virus (HEV) infection in Japanese liver transplant recipients and ...

IFN-λ3 as a host immune response in acute hepatitis E virus infection.

Murata K Kang JH Nagashima S Matsui T Karino Y Yamamoto Y Atarashi T Oohara M Uebayashi M Sakata H Matsubayashi K Takahashi K Arai M Mishiro S Sugiyama M Mizokami M Okamoto H

Cytokine 125 154816-154816 2020年1月 [査読有り]

Antiviral candidates against the hepatitis E virus (HEV) and their combinations inhibit HEV growth in in vitro.

Takashi Nishiyama Tominari Kobayashi Suljid Jirintai Shigeo Nagashima Putu Prathiwi Primadharsini Tsutomu Nishizawa Hiroaki Okamoto

Antiviral research 170 104570-104570 2019年10月

Hepatitis E is a global public health problem. Ribavirin (RBV) and pegylated interferon alpha are currently administered to cure hepatitis E. Recently, in combination with RBV, sofosbuvir (SOF), an anti-hepatitis C virus nucleotide analog, is also...