研究者氏名	長嶋茂雄
	ナガシマシゲオ
URL	http://kaken.nii.ac.jp/d/r/60433116.ja.html
所属	自治医科大学
部署	医学部感染・免疫学講座　ウイルス学部門
職名	准教授
J-Global ID	201401008778902426

研究キーワード

Tsg101 ,E型肝炎ウイルス ,ESCRT機構 ,放出 ,MVB経路 ,粒子形成 ,分子疫学 ,B群 ,ロタウイルス ,MRSA ,生理学 ,浸淫状況 ,PVL ,新種 ,プロテオーム ,スタフィロコアグラーゼ ,黄色ブドウ球菌 ,成人 ,熱帯地域 ,感染培養系 ,アジア ,多剤排出蛋白 ,下痢症 ,感染性cDNAクローン ,ゲノム変異 ,下痢 ,PSAPモチーフ ,腸球菌

研究分野

ライフサイエンス / ウイルス学 /
ライフサイエンス / 衛生学、公衆衛生学分野：実験系を含む /
ライフサイエンス / 細胞生物学 /
ライフサイエンス / 分子生物学 /

経歴

2013年

自治医科大学医学部講師

論文

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First detection and characterization of rat hepatitis E Virus (HEV-C1) in Japan

Masaharu Takahashi Satoshi Kunita Manri Kawakami Teruki Kadosaka Hiromi Fujita Nobuhiro Takada Masao Miyake Tominari Kobayashi Hiroshi Ohnishi Shigeo Nagashima Kazumoto Murata Hiroaki Okamoto

VIRUS RESEARCH 314 2022年6月

Rat hepatitis E virus (HEV-C1) in the Orthohepevirus C species has been reported to cause zoonotic infection and hepatitis in humans. HEV-C1 strains have been detected from wild rats in many countries in Europe, Asia, and North America. However, i...

Subclinical hepatitis E virus (HEV) infection detected by nucleic acid amplification test on blood donation: short-term positivity for immunoglobulin G class of antibody against HEV.

Izumi Hasegawa Tatsunori Nakano Hiroki Koguchi Naruomi Jinno Noboru Hirashima Shigeo Nagashima Masaharu Takahashi Kazumoto Murata Hiroaki Okamoto

Clinical journal of gastroenterology 15(4) 750-754 2022年5月

A case of subclinical hepatitis E virus (HEV) infection was detected by nucleic acid amplification test on blood donation. The patient was followed-up until day 220 after the blood donation but showed no symptoms throughout the observation period....

Development of recombinant infectious hepatitis E virus harboring the nanoKAZ gene and its application in drug screening

Putu Prathiwi Primadharsini Shigeo Nagashima Takashi Nishiyama Masaharu Takahashi Kazumoto Murata Hiroaki Okamoto

Journal of Virology 96(6) 2022年2月

Bioluminescent reporter viruses are essential tools in molecular virological research. They have been widely used to investigate viral life cycles and in the development of antiviral drugs.Hepatitis E virus (HEV) is a quasi-enveloped virus with a ...

Identification of hepatitis E virus in wild sika deer in Japan.

Masaharu Takahashi Akira Nishizono Manri Kawakami Emiko Fukui Emiko Isogai Hiroyuki Matsuoka Seigo Yamamoto Hitoshi Mizuo Shigeo Nagashima Kazumoto Murata Hiroaki Okamoto

Virus research 308 198645-198645 2022年1月

Hepatitis E virus (HEV) is a zoonotic agent mainly transmitted through the consumption of uncooked or undercooked meat products derived from infected animals. In Japan, domestic pigs and wild boars are the major animal reservoirs, and whether or n...

Chronic Infection with Hepatitis C Virus Subtype 1 g in a Japanese Patient Successfully Treated with Glecaprevir/Pibrentasvir.

Takeshi Hatanaka Satoru Kakizaki Takuya Kaburagi Naoto Saito Sachi Nakano Yoichi Hazama Sachiko Yoshida Yoko Hachisu Yoshiki Tanaka Teruo Yoshinaga Kenji Kashiwabara Atsushi Naganuma Yuichi Yamazaki Toshio Uraoka Shigeo Nagashima Masaharu Takahashi Tsutomu Nishizawa Kazumoto Murata Hiroaki Okamoto

Internal medicine (Tokyo, Japan) 61(10) 1537-1543 2021年12月

A 66-year-old man, who had undergone plasma exchange 30 years previously in Egypt for the treatment of falciparum malaria, was referred to our hospital for treatment of chronic hepatitis C (HCV). An analysis of the 655-nucleotide 5'-untranslated r...