分子病態治療研究センター再生医学研究部

花園豊

研究者氏名	花園豊
	ハナゾノユタカ
URL	http://kaken.nii.ac.jp/d/r/70251246.ja.html
所属	自治医科大学
部署	分子病態治療研究センター再生医学研究部
職名	教授
学位	博士(医学)(東京大学)
J-Global ID	201401078781431912

研究キーワード

幹細胞 ,再生医学 ,大型動物 ,ブタ ,iPS細胞 ,造血幹細胞 ,霊長類モデル ,ヒツジ ,ES細胞 ,造血幹細胞移植

研究分野

ライフサイエンス / 血液、腫瘍内科学 /
ライフサイエンス / 実験動物学 /

経歴

2012年

自治医科大学医学部教授

論文

<2 345 6 >

Generation of Naive-Like Porcine-Induced Pluripotent Stem Cells Capable of Contributing to Embryonic and Fetal Development

Shuh-hei Fujishiro Kazuaki Nakano Yoshihisa Mizukami Takuya Azami Yoshikazu Arai Hitomi Matsunari Rikiya Ishino Takashi Nishimura Masahito Watanabe Tomoyuki Abe Yutaka Furukawa Kazuhiro Umeyama Shinya Yamanaka Masatsugu Ema Hiroshi Nagashima Yutaka Hanazono

STEM CELLS AND DEVELOPMENT 22(3) 473-482 2013年2月 [査読有り]

In pluripotent stem cells (PSCs), there are 2 types: naive and primed. Only the naive type has the capacity for producing chimeric offspring. Mouse PSCs are naive, but human PSCs are in the primed state. Previously reported porcine PSCs appear in ...

Hollow Fiber Vitrification Provides a Novel Method for Cryopreserving In Vitro Maturation/Fertilization-Derived Porcine Embryos

Miki Maehara Hitomi Matsunari Kasumi Honda Kazuaki Nakano Yasuhiro Takeuchi Takahiro Kanai Taisuke Matsuda Yukina Matsumura Yui Hagiwara Norihisa Sasayama Akio Shirasu Masashi Takahashi Masahito Watanabe Kazuhiro Umeyama Yutaka Hanazono Hiroshi Nagashima

BIOLOGY OF REPRODUCTION 87(6) 133 2012年12月 [査読有り]

In vitro matured (IVM) oocytes have been used to create genetically modified pigs for various biomedical purposes. However, porcine embryos derived from IVM oocytes are very cryosensitive. Developing improved cryopreservation methods would facilit...

Maternal administration of busulfan before in utero transplantation of human hematopoietic stem cells enhances engraftments in sheep

Tomoyuki Abe Shigeo Masuda Yujiro Tanaka Suguru Nitta Yoshihiro Kitano Satoshi Hayashi Yutaka Hanazono Yoshikazu Nagao

EXPERIMENTAL HEMATOLOGY 40(6) 436-444 2012年6月 [査読有り]

In utero transplantation (IUT) of human hematopoietic stem cells has been conducted in sheep, which are used as large animal models of human hematopoietic reconstitution and models for clinical IUT; however, the levels of engraftment have generall...

A Simplified In Vitro Teratoma Assay for Pluripotent Stem Cells Injected Into Rodent Fetal Organs.

Masuda S Yokoo T Sugimoto N Doi M Fujishiro SH Takeuchi K Kobayashi E Hanazono Y

Cell medicine 3(1-3) 103-112 2012年1月 [査読有り]

Migration of cells from the yolk sac to hematopoietic tissues after in utero transplantation of early and mid gestation canine fetuses.

Shigeo Masuda Satoshi Hayashi Naohide Ageyama Hiroaki Shibata Tomoyuki Abe Yoshikazu Nagao Yutaka Hanazono

Transplantation 92(2) e5-6; author reply e6-7-6; author reply e6 2011年7月 [査読有り]