分子病態治療研究センター再生医学研究部

花園豊

研究者氏名	花園豊
	ハナゾノユタカ
URL	http://kaken.nii.ac.jp/d/r/70251246.ja.html
所属	自治医科大学
部署	分子病態治療研究センター再生医学研究部
職名	教授
学位	博士(医学)(東京大学)
J-Global ID	201401078781431912

研究キーワード

幹細胞 ,再生医学 ,大型動物 ,ブタ ,iPS細胞 ,造血幹細胞 ,霊長類モデル ,ヒツジ ,ES細胞 ,造血幹細胞移植

研究分野

ライフサイエンス / 血液、腫瘍内科学 /
ライフサイエンス / 実験動物学 /

経歴

2012年

自治医科大学医学部教授

論文

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MHC-Matched Induced Pluripotent Stem Cells Can Attenuate Cellular and Humoral Immune Responses but Are Still Susceptible to Innate Immunity in Pigs

Yoshihisa Mizukami Tomoyuki Abe Hiroaki Shibata Yukitoshi Makimura Shuh-hei Fujishiro Kimihide Yanase Shuji Hishikawa Eiji Kobayashi Yutaka Hanazono

PLOS ONE 9(6) e98319 2014年6月 [査読有り]

Recent studies have revealed negligible immunogenicity of induced pluripotent stem (iPS) cells in syngeneic mice and in autologous monkeys. Therefore, human iPS cells would not elicit immune responses in the autologous setting. However, given that...

DNA methylation profiles provide a viable index for porcine pluripotent stem cells

Yoshikazu Arai Jun Ohgane Shuh-Hei Fujishiro Kazuaki Nakano Hitomi Matsunari Masahito Watanabe Kazuhiro Umeyama Dai Azuma Naomi Uchida Nozomu Sakamoto Tomohiro Makino Shintaro Yagi Kunio Shiota Yutaka Hanazono Hiroshi Nagashima

Genesis 51(11) 763-776 2013年11月 [査読有り]

Porcine induced pluripotent stem cells (iPSCs) provide useful information for translational research. The quality of iPSCs can be assessed by their ability to differentiate into various cell types after chimera formation. However, analysis of chim...

Generation of Interleukin-2 Receptor Gamma Gene Knockout Pigs from Somatic Cells Genetically Modified by Zinc Finger Nuclease-Encoding mRNA

Masahito Watanabe Kazuaki Nakano Hitomi Matsunari Taisuke Matsuda Miki Maehara Takahiro Kanai Mirina Kobayashi Yukina Matsumura Rieko Sakai Momoko Kuramoto Gota Hayashida Yoshinori Asano Shuko Takayanagi Yoshikazu Arai Kazuhiro Umeyama Masaki Nagaya Yutaka Hanazono Hiroshi Nagashima

PLOS ONE 8(10) e76478 2013年10月 [査読有り]

Zinc finger nuclease (ZFN) is a powerful tool for genome editing. ZFN-encoding plasmid DNA expression systems have been recently employed for the generation of gene knockout (KO) pigs, although one major limitation of this technology is the use of...

Generating Porcine Chimeras Using Inner Cell Mass Cells and Parthenogenetic Preimplantation Embryos

Kazuaki Nakano Masahito Watanabe Hitomi Matsunari Taisuke Matsuda Kasumi Honda Miki Maehara Takahiro Kanai Gota Hayashida Mirina Kobayashi Momoko Kuramoto Yoshikazu Arai Kazuhiro Umeyama Shuh-hei Fujishiro Yoshihisa Mizukami Masaki Nagaya Yutaka Hanazono Hiroshi Nagashima

PLOS ONE 8(4) e61900 2013年4月 [査読有り]

Background: The development and validation of stem cell therapies using induced pluripotent stem (iPS) cells can be optimized through translational research using pigs as large animal models, because pigs have the closest characteristics to humans...

[Stem cell research using large animals].

Hanazono Y

[Rinsho ketsueki] The Japanese journal of clinical hematology 54(4) 329-335 2013年4月 [査読有り]