Retroviral vectors are used for gene transduction into cells and have been applied to gene therapy. Retroviral vectors using envelope protein (Env) of RD-114 virus, a feline endogenous retrovirus, have been used for gene transduction. In this stud...
Recent developments in genome sequencing techniques have led to the identification of huge numbers of endogenous retroviruses (ERV) in various mammals. ERVs, which occupy 8%-13% of mammalian genomes, are believed to affect mammalian evolution and ...
JOURNAL OF VIROLOGY 88(12) 6896-6905 2014年6月 [査読有り]
Endogenous retroviruses (ERVs) are the remnants of retroviral infection of ancestral germ cells. Mutations introduced into ERVs halt the production of infectious agents, but their effects on the function of retroviral proteins are not fully unders...
Yuki Nakaya Katsuo Koshi So Nakagawa Kazuyoshi Hashizume Takayuki Miyazawa
Journal of Virology 87(19) 10563-10572 2013年10月 [査読有り]
ABSTRACT
During placentation, mammals employ different strategies for nourishing and supporting fetuses. Members of the Bovidae family, consisting of cloven-hoofed ruminants, utilize multiple maternal attachment points on the placenta, known as ...
So Nakagawa Hanako Bai Toshihiro Sakurai Yuki Nakaya Toshihiro Konno Takayuki Miyazawa Takashi Gojobori Kazuhiko Imakawa
GENOME BIOLOGY AND EVOLUTION 5(2) 296-306 2013年 [査読有り]
In evolution of mammals, some of essential genes for placental development are known to be of retroviral origin, as syncytin-1 derived from an envelope (env) gene of an endogenous retrovirus (ERV) aids in the cell fusion of placenta in humans. Alt...
自治医科大学
医学部