BACKGROUND: Fabry disease (FD) is an inherited lysosomal storage disease caused by deficiency of α-galactosidase A (α-Gal A) encoded by the GLA gene. The symptoms of FD occur as a result of the accumulation of globotriaosylceramide (Gb3), comprisi...
Shota Okabe Yuki Takayanagi Masahide Yoshida Tatsushi Onaka
iScience 26(3) 106243-106243 2023年3月
Whether commonly used experimental animals show aversion toward inequality of social rewards, as humans do remains unknown. We examined whether rats emitted the 22-kHz distress calls under social reward inequality. Rats showed affiliative behavior...
Masahide Yoshida Tomoko Saito Yuki Takayanagi Yoshikazu Totsuka Tatsushi Onaka
Scientific reports 12(1) 20390-20390 2022年11月
The CRISPR-Cas9 method for generation of knock-in mutations in rodent embryos yields many F0 generation candidates that may have the designed mutations. The first task for selection of promising F0 generations is to analyze genomic DNA which likel...
Brain and nerve = Shinkei kenkyu no shinpo 75(11) 1205-1209 2023年11月
Resilience is a term that describes the capacity of coping with and recovering from stress and adversity. In terms of the concept of allostasis, resilience is the ability to appropriately regulate allostasis, efficiently terminate the allostatic r...
自治医科大学
医学部