研究者氏名	大森司

URL	http://kaken.nii.ac.jp/d/r/70382843.ja.html
所属	自治医科大学
部署	医学部生化学講座病態生化学部門
職名	教授
J-Global ID	201401094169729665

研究キーワード

ST2 ,血友病 ,第VIII因子 ,遺伝子治療 ,第IX因子 ,血小板 ,スフィンゴシン1-リン酸

研究分野

ライフサイエンス / 血液、腫瘍内科学 /
ライフサイエンス / 整形外科学 /

経歴

2017年4月

現在

自治医科大学医学部生化学講座病態生化学部門教授

委員歴

12 >

2020年6月

現在

日本血栓止血学会理事

現在

日本血栓止血学会代議員

現在

臨床血液編集委員

現在

日本血液学会代議員

日本血液学会教育委員

受賞

12 >

2018年

自治医科大学優秀論文賞

2018年

武田医学振興財団薬科学シンポジウム褒賞金受賞

2017年

日本血液学会国際シンポジウムOral Presentation Award Platinum

2012年

自治医科大学優秀論文賞

2010年

自治医科大学優秀論文賞

論文

Hemophilia gene therapy-New country initiatives.

Ulrike M Reiss Lei Zhang Tsukasa Ohmori

Haemophilia : the official journal of the World Federation of Hemophilia Suppl(3) 132-141 2021年2月 [査読有り]

Gene therapy is an opportunity for haemophilia patients to receive a one-time treatment and have lasting factor levels for years or decades instead of dependence on repeated administration within short intervals and on sustained supply of drug. Gr...

Altered behavior in mice overexpressing soluble ST2.

Motoshi Kikuchi Kenkichi Takase Morisada Hayakawa Hiroko Hayakawa Shin-Ichi Tominaga Tsukasa Ohmori

Molecular brain 13(1) 74-74 2020年5月 [査読有り]

Psychoneuroimmunological studies have clearly demonstrated that both cellular and humoral immunity are related to major depression. Soluble ST2 is regarded as a key molecule regulating immune system as well as cell proliferation. Indeed, soluble S...

Induction of IκBζ Augments Cytokine and Chemokine Production by IL-33 in Mast Cells.

Hiromi Ohto-Ozaki Morisada Hayakawa Nobuhiko Kamoshita Takashi Maruyama Shin-Ichi Tominaga Tsukasa Ohmori

Journal of immunology (Baltimore, Md. : 1950) 204(8) 2033-2042 2020年4月 [査読有り]

IκBζ (encoded by the Nfkbiz) is a member of the nuclear IκB family, which is involved in the expression of secondary response genes based on signals from TLR or IL-1R. ST2L, an IL-33R, is a member of the IL-1R family and abundantly expressed in ti...

Advances in gene therapy for hemophilia: basis, current status, and future perspectives.

Tsukasa Ohmori

International journal of hematology 111(1) 31-41 2020年1月 [査読有り]

Hemophilia is a congenital hemorrhagic disease caused by genetic abnormalities in coagulation factor VIII or factor IX. Current conventional therapy to prevent bleeding requires frequent intravenous injections of coagulation factor concentrates fr...

Safety of intra-articular transplantation of lentivirally transduced mesenchymal stromal cells for haemophilic arthropathy in a non-human primate.

Tsukasa Ohmori Hiroaki Mizukami Yuko Katakai Sho Kawai Hitoyasu Nakamura Makoto Inoue Tsugumine Shu Hideharu Sugimoto Yoichi Sakata

International journal of hematology 108(3) 239-245 2018年9月 [査読有り]

Joint bleeding and resultant arthropathy are major determinants of quality of life in haemophilia patients. We previously developed a mesenchymal stromal cell (MSC)-based treatment approach for haemophilic arthropathy in a mouse model of haemophil...

もっとみる