EUROPEAN JOURNAL OF PHARMACOLOGY 749 98-106 2015年2月 [査読有り]
A group of synthetic substance P (SP) antagonists, such as [Arg(6),D-Trp(7,9),N(Me)Phe(8)]-substance P(6-11) and [D-Arg(1),D-Phe(5),D-Trp(7,9),Leu(11)]-substance P, bind to a range of distinct G-protein-coupled receptor (GPCR) family members, incl...
Shizue Masuki Eri Sumiyoshi Taka-aki Koshimizu Jinze Qian Keiichi Higuchi Gozoh Tsujimoto Hiroshi Nose
JOURNAL OF PHYSIOLOGY-LONDON 591(14) 3651-3665 2013年7月 [査読有り]
We previously reported that cerebral activation suppressed baroreflex control of heart rate (HR) at the onset of voluntary locomotion. In the present study, we examined whether vasopressin V1a receptors in the brain were involved in these response...
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 57 72-81 2013年4月 [査読有り]
Metastasis-associated protein, S100A4 is suggested as a marker for fibrosis in several organs. It also modulates DNA binding of p53 and affects its function. However, the functional role of S100A4 in the myocardium has remained unclear. Therefore,...
The tocolytic agent ritodrine acts on the β2-adrenoceptor and is an effective treatment option for preterm labor. However, several adverse effects of ritodrine therapy, including liver damage, have been noted. To elucidate the underlying mechanism...
T Koshimizu G Tsujimoto A Hirasawa Y Kitagawa A Tanoue
CARDIOVASCULAR RESEARCH 63(4) 662-672 2004年9月
Background: Increasing evidence from clinical trials indicates that carvedilol, an antagonist of alpha1- and beta-adrenergic receptors (ARs), provides an effective treatment for chronic heart failure, whereas nonselective alpha1-AR blockade has an...
T Koshimizu S Ueno A Tanoue N Yanagihara SS Stojilkovic G Tsujimoto
JOURNAL OF BIOLOGICAL CHEMISTRY 277(49) 46891-46899 2002年12月
P2X purinergic receptors (P2XRs) differ among themselves with respect to their ligand preferences and channel kinetics during activation, desensitization, and recovery. However, the contributions of distinct receptor subdomains to the subtype-spec...
自治医科大学
医学部