Manabu Takahashi Hiroaki Yagyu Fumiko Tazoe Shuichi Nagashima Taichi Ohshiro Kenta Okada Jun-Ichi Osuga Ira J. Goldberg Shun Ishibashi
Journal of Lipid Research 54(4) 1124-1134 2013年4月 [査読有り]
The role of macrophage lipoprotein lipase (LpL) in the development of atherosclerosis and adiposity was examined in macrophage LpL knockout (MLpLKO) mice. MLpLKO mice were generated using cre-loxP gene targeting. Loss of LpL in macrophages did not...
Postprandial hyperglycemia and/or hyperlipidemia can contribute to development of atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The objective of this study was to compare the effects of miglitol and sitagliptin on postprandial ...
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 32(8) 1824-U277 2012年8月 [査読有り]
Objective-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) catalyzes the rate-limiting step in cholesterol biosynthesis and has proven to be an effective target of lipid-lowering drugs, statins. The aim of this study was to understand the r...
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 18(3) 190-199 2011年 [査読有り]
Aim: Adipocyte lipolysis is mediated by a family of triglyceride (TG) lipases consisting of hormone-sensitive lipase (LIPE), adipose triglyceride lipase (PNPLA2) and carboxylesterase 1 (CES1); however, little is known about the relationship betwee...
自治医科大学
医学部