JOURNAL OF MOLECULAR ENDOCRINOLOGY 52(2) 145-158 2014年4月 [査読有り]
Mammalian tribbles homolog 1 (TRIB1) regulates hepatic lipogenesis and is genetically associated with plasma triglyceride (TG) levels and cholesterol, but the molecular mechanisms remain obscure. We explored these mechanisms in mouse livers transf...
Recent genome-wide association studies (GWASs) showed that single nucleotide polymorphisms (SNPs) in FADS1/FADS2 were associated with plasma lipid concentrations in populations with European ancestry. We investigated the associations between the S...
Retinol-binding protein 4 (RBP4) is a recently identified adipokine that was involved in insulin resistance. RBP4 is predominantly expressed from the liver in normal metabolic state to transport retinoids throughout the body, but the exact physiol...
K. Nakayama T. Bayasgalan K. Yamanaka M. Kumada T. Gotoh N. Utsumi Y. Yanagisawa M. Okayama E. Kajii S. Ishibashi S. Iwamoto
JOURNAL OF MEDICAL GENETICS 46(6) 370-374 2009年6月 [査読有り]
Background: Recent genome wide association studies discovered seven novel loci that influence plasma concentrations of triglycerides, high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol in Europeans. To date, large scale r...
Objective: The aim of the study was to investigate genetic heterogeneity among local Japanese populations. Methods: We performed a single nucleotide polymorphism (SNP) study of four demographically distinct local populations (population 1: a large...
S Iwamoto H Suganuma T Kamesaki T Omi H Okuda E Kajii
JOURNAL OF BIOLOGICAL CHEMISTRY 275(35) 27324-27331 2000年9月 [査読有り]
fRhesus-associated glycoprotein is a critical co-factor in the expression of rhesus blood group antigens. We identified and cloned an erythroid-specific major DNase I-hypersensitive site located about 10 kilobases upstream from the translation sta...
S Iwamoto M Yamasaki M Kawano H Okuda T Omi J Takahashi Y Tani M Omine E Kajii
INTERNATIONAL JOURNAL OF HEMATOLOGY 68(3) 257-268 1998年10月 [査読有り]
Rh blood group antigens are associated with non-glycosylated human erythrocyte membrane proteins encoded by two closely related genes, RHCE and RHD, and with a glycoprotein, a critical co-er;pressing factor encoded by the RH50 gene. The sequence a...
S Iwamoto T Omi M Yamasaki H Okuda M Kawano E Kajii
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 243(1) 233-240 1998年2月 [査読有り]
The Rh blood group antigens are carried by two distinct but homologous membrane proteins encoded by two closely related genes, RHCE and RHD. Rh50 glycoprotein is the membrane protein tightly associated with Rh polypeptides and is critical for expr...
自治医科大学