Shu Hisata   Toshiaki Sakisaka   Takeshi Baba   Tomohiro Yamada   Kazubiro Aoki   Mlchiyuki Matsuda   Yoshimi Takai   
JOURNAL OF CELL BIOLOGY 178(5) 843-860 2007年8月
Neurotrophins, such as NGF and BDNF, induce sustained activation of Rap1 small G protein and ERK, which are essential for neurite outgrowth. We show involvement of a GDP/GTP exchange factor (GEF) for Rap1, PDZ-GEFI, in these processes. PDZ-GEF1 is...