研究者氏名	嶋田明
	シマダアキラ
URL
所属	自治医科大学
部署	附属病院　とちぎ子ども医療センター小児科
職名	教授
学位	医学博士(鳥取大学)
J-Global ID	201001053900160599

研究キーワード

感染免疫学 ,血液腫瘍学 ,小児科 ,hematology/oncology. immunology/infectious disease ,Pediatrics

研究分野

ライフサイエンス / 胎児医学、小児成育学 /

経歴

12 >

2021年6月

現在

自治医科大学小児科教授

2016年7月

2021年5月

岡山大学小児血液腫瘍科准教授

2012年4月

2016年6月

岡山大学小児科講師

2009年10月

2012年3月

名古屋大学小児科病院助教

2007年8月

2009年8月

St.Jude Children's Research Hospital Department of Pharmacology Post.Doc fellow

学歴

1999年

鳥取大学医学研究科

1999年

鳥取大学

1992年

鳥取大学医学部

1992年

鳥取大学

受賞

2011年

クレディセゾン賞

論文

12 3 4 5 >

High IL2RA/CD25 expression is a prognostic stem cell biomarker for pediatric acute myeloid leukemia without a core-binding factor.

Takahiro Aoki Norio Shiba Shinichi Tsujimoto Genki Yamato Yusuke Hara Shota Kato Kenichi Yoshida Seishi Ogawa Yasuhide Hayashi Shotaro Iwamoto Tomohiko Taki Akira Shimada Yuka Iijima-Yamashita Keizo Horibe Akio Tawa Takashi Taga Souichi Adachi Daisuke Tomizawa

Pediatric blood & cancer e30803 2023年12月

CD25 is an aberrant marker expressed on the leukemic stem cell (LSC) surface and an immunotherapy target in acute myeloid leukemia (AML). However, the clinical prevalence and significance of CD25 expression in pediatric AML are unknown. High IL2RA...

TP53 and RB1 alterations characterize poor prognostic subgroups in pediatric acute myeloid leukemia.

Yusuke Hara Norio Shiba Kenichi Yoshida Genki Yamato Taeko Kaburagi Yuichi Shiraishi Kentaro Ohki Yusuke Shiozawa Machiko Kawamura Hirohide Kawasaki Manabu Sotomatsu Takumi Takizawa Hidemasa Matsuo Akira Shimada Nobutaka Kiyokawa Daisuke Tomizawa Takashi Taga Etsuro Ito Keizo Horibe Satoru Miyano Souichi Adachi Tomohiko Taki Seishi Ogawa Yasuhide Hayashi

Genes, chromosomes & cancer 62(7) 412-422 2023年7月

Pediatric acute myeloid leukemia (AML) is a poor prognostic subtype of pediatric leukemia. However, the detailed characteristics of many genetic abnormalities are yet to be established in this disease. Although TP53 and RB1 are established as repr...

Genome-wide DNA methylation analysis in pediatric acute myeloid leukemia.

Genki Yamato Tomoko Kawai Norio Shiba Junji Ikeda Yusuke Hara Kentaro Ohki Shin-Ichi Tsujimoto Taeko Kaburagi Kenichi Yoshida Yuichi Shiraishi Satoru Miyano Nobutaka Kiyokawa Daisuke Tomizawa Akira Shimada Manabu Sotomatsu Hirokazu Arakawa Souichi Adachi Takashi Taga Keizo Horibe Seishi Ogawa Kenichiro Hata Yasuhide Hayashi

Blood advances 6(11) 3207-3219 2022年6月

We investigated genome-wide DNA methylation patterns in 64 pediatric patients with acute myeloid leukemia (AML). Based on unsupervised clustering with the 567 most variably methylated cytosine guanine dinucleotide (CpG) sites, patients were catego...

Correction to: Post-induction MRD by FCM and GATA1-PCR are significant prognostic factors for myeloid leukemia of Down syndrome (Leukemia, (2021), 35, 9, (2508-2516), 10.1038/s41375-021-01157-w)

Takashi Taga Shiro Tanaka Daisuke Hasegawa Kiminori Terui Tsutomu Toki Shotaro Iwamoto Hidefumi Hiramatsu Takako Miyamura Yoshiko Hashii Hiroshi Moritake Hideki Nakayama Hiroyuki Takahashi Akira Shimada Tomohiko Taki Etsuro Ito Asahito Hama Masafumi Ito Katsuyoshi Koh Daiichiro Hasegawa Akiko M. Saito Souichi Adachi Daisuke Tomizawa

Leukemia 35(12) 3622-3624 2021年12月

Following the publication of this article, the authors noted an error in the data reported.

Genome-wide DNA methylation analysis in pediatric AML: The JCCG-JPLSG AML-05 study(和訳中)

大和玄季河合智子柴徳生原勇介大木健太郎鏑木多映子吉田健一白石友一宮野悟清河信敬富澤大輔嶋田明外松学荒川浩一足立壮一多賀崇堀部敬三小川誠司秦健一郎林泰秀

日本血液学会学術集会 83回 OS2-4 2021年9月

MISC

12 3 4 5 >

Prognosis of Pediatric Acute Myeloid Leukemia with KMT2A-MLLT3 According to DNA Methylation Patterns: Jccg JPLSG AML-05 Study

Genki Yamato Tomoko Kawai Norio Shiba Yusuke Hara Kentaro Ohki Taeko Kaburagi Etsuko Ishikita Hirohide Kawasaki Kenichi Yoshida Yuichi Shiraishi Satoru Miyano Nobutaka Kiyokawa Daisuke Tomizawa Akira Shimada Manabu Sotomatsu Takumi Takizawa Souichi Adachi Takashi Taga Keizo Horibe Seishi Ogawa Kenichiro Hata Yasuhide Hayashi

BLOOD 140 9134-9135 2022年11月

ARHGEF2-NTRK1融合遺伝子を有する高悪性度グリア神経細胞腫瘍の1例

坪井伸成黒住和彦中野嘉子鷲尾佳奈嶋田明吉田朗彦河野隆志市村幸一柳井広之伊達勲

Brain Tumor Pathology (Web) 37(Supplement) 2020年

Predisposition to Prolonged Neutropenia After Chemotherapy was Associated With Better Prognosis in Patients With Acute Myeloid Leukemia

Takahiro Aoki Hiroyuki Takahashi Shiro Tanaka Norio Shiba Daiichiro Hasegawa Shotaro Iwamoto Kiminori Terui Hiroshi Moritake Hideki Nakayama Akira Shimada Katsuyoshi Koh Hiroaki Goto Yoshiyuki Kosaka Akiko Saito Keizo Horibe Akitoshi Kinoshita Daisuke Tomizawa Akio Tawa Takashi Taga Souichi Adachi

PEDIATRIC BLOOD & CANCER 66 S21-S21 2019年12月

JACLS ALL02研究におけるAcute Mixed Leukemiaの遺伝子変異(Genetic Alterations in Acute Mixed Leukemia, Result of JACLS-ALL02 study)

Shimada Akira Hasegawa Daiichiro Imamura Toshihiko Kaneda Makoto Yagi Keiko Takahashi Yoshihiro Usami Ikuya Suenobu Souichi Nishimura Shinichiro Hashii Keiko Deguchi Takao Saito Akiko Kato Kouji Kosaka Yoshiyuki Hirayama Masahiro Iguchi Akihiro Kawasaki Hirohide Hori Hiroki Sato Atsushi Nakahata Tatsutoshi Oda Megumi Ueno Hiroo Sanada Masashi Ogawa Seishi Hara Junichi Horibe Keizo

日本小児血液・がん学会雑誌 56(4) 194-194 2019年10月

TP53遺伝子異常を伴う小児急性骨髄性白血病の臨床像と分子生物学異常の解析(Clinical and molecular characterization of pediatric acute myeloid leukemia with TP53 alterations)

Hara Yusuke Taki Tomohiko Yamato Genki Yoshida Kenichi Shiba Norio Kaburagi Taeko Shiraishi Yuichi Ohki Kentaro Kawamura Machiko Sotomatsu Manabu Arakawa Hirokazu Matsuo Hidemasa Shimada Akira Toki Tsutomu Kiyokawa Nobutaka Tomizawa Daisuke Taga Takashi Ito Etsuro Horibe Keizo Miyano Satoru Ogawa Seishi Adachi Souichi Hayashi Yasuhide

日本小児血液・がん学会雑誌 56(4) 192-192 2019年10月