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武藤弘行

研究者氏名	武藤弘行
	ムトウヒロユキ
URL
所属	自治医科大学
部署	医学部情報センター　／　内科学講座消化器内科学部門
職名	教授
学位	医学博士(東京大学)
J-Global ID	201101096449019060

研究キーワード

胃癌

研究分野

ライフサイエンス / 消化器内科学 /

論文

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SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans

Miho Sashikawa Kimura Hiroyuki Mutoh Kentaro Sugano

JOURNAL OF GASTROENTEROLOGY 46(11) 1292-1299 2011年11月 [査読有り]

Background SOX9 is a marker for stem cells in the intestine and overexpression of SOX9 is found in some types of cancer. However, the expression of SOX9 in normal stomach, precancerous intestinal metaplasia, and gastric carcinoma has not yet been ...

Cell lineage dynamics in the process leading to intestinal metaplasia

Hirotsugu Sakamoto Hiroyuki Mutoh Hiroko Hayakawa Miho Sashikawa Kentaro Sugano

JOURNAL OF GASTROENTEROLOGY 46(5) 620-628 2011年5月 [査読有り]

Gene expression in the early stage of the transition to intestinal metaplasia in human gastric mucosa has not been determined. In this study, we investigated the temporal relationship between cell lineage changes and intestine-specific gene expres...

Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa

Hiroyuki Mutoh Miho Sashikawa Kentaro Sugano

DIFFERENTIATION 81(2) 92-98 2011年2月 [査読有り]

Sox2 is closely related to the gastric phenotype. Sox2 plays a pivotal role in gastric epithelial differentiation in the adult. Sox2 expression is reduced in Helicobacter pylori-associated intestinal metaplastic change of the gastric epithelium. T...

Expression of Claudin-2 in intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach

Hirotsugu Sakamoto Hiroyuki Mutoh Kentaro Sugano

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 45(11) 1273-1280 2010年11月 [査読有り]

Objective. Cdx2 is expressed in human intestinal metaplastic mucosa and induces intestinal metaplastic mucosa in Cdx2-transgenic mouse stomach. Claudin-2 is a structural component of tight junctions in the intestine and Cdx2 activates the Claudin-...

Monocyte chemoattractant protein-1 is generated via TGF-beta by myofibroblasts in gastric intestinal metaplasia and carcinoma without H-pylori infection

Hiroyuki Mutoh Miho Sashikawa Hiroko Hayakawa Kentaro Sugano

CANCER SCIENCE 101(8) 1783-1789 2010年8月 [査読有り]

Helicobacter pylori (H. pylori) stimulates secretion of monocyte chemoattractant protein 1 (MCP-1) from gastric mucosa. Monocyte chemoattractant protein-1 (MCP-1) expression and macrophage infiltration are recognized in human gastric carcinoma. We...