研究者氏名	神田善伸
	カンダヨシノブ
URL	http://www.jichi.ac.jp/saitama-sct
所属	自治医科大学
部署	医学部内科学講座　血液学部門　／附属病院・附属さいたま医療センター血液科（兼任）
職名	教授
J-Global ID	200901030637051398

研究キーワード

造血幹細胞移植

研究分野

ライフサイエンス / 血液、腫瘍内科学 /

論文

12 3 4 5 >

Treatment strategy at the decision for allogeneic transplantation in patients with myelodysplastic syndrome in the era of azacitidine: A KSGCT prospective study.

Shinichi Kako Shun-Ichi Kimura Hidenori Wada Yusuke Komiya Hideki Nakasone Masatoshi Sakurai Jun Kato Masatsugu Tanaka Eriko Fujii Takayoshi Tachibana Wataru Yamamoto Maki Hagihara Reiko Watanabe Akira Yokota Hirofumi Nakano Takehiko Mori Chiaki Nakaseko Heiwa Kanamori Shinichiro Okamoto Yoshinobu Kanda

Leukemia research 133 107371-107371 2023年10月

The optimal bridge strategy at the decision for allogeneic hematopoietic stem cell transplantation (HSCT) in patients with myelodysplastic syndrome (MDS) is unclear. We performed a prospective observational study in which 110 patients with MDS who...

Substitution of calcineurin inhibitors with corticosteroids after allogeneic hematopoietic cell transplantation.

Shimpei Matsumi Shun-Ichi Kimura Yuhei Nakamura Masakatsu Kawamura Junko Takeshita Shunto Kawamura Nozomu Yoshino Yukiko Misaki Kazuki Yoshimura Ayumi Gomyo Yosuke Okada Yu Akahoshi Masaharu Tamaki Machiko Kusuda Kazuaki Kameda Hidenori Wada Aki Tanihara Miki Sato Hideki Nakasone Shinichi Kako Yoshinobu Kanda

International journal of hematology 2023年7月

Combination of calcineurin inhibitors (CIs) with short-term methotrexate is a standard prophylactic regimen for graft-versus-host disease (GVHD). However, it is sometimes difficult to continue CIs due to adverse effects, such as renal impairment a...

Antibody-mediated pathogenesis of chronic GVHD through DBY/HLA class II complexes and induction of a GVL effect.

Kento Umino Kaoru Morita Takashi Ikeda Shin-Ichiro Kawaguchi Takashi Nagayama Shoko Ito Daisuke Minakata Masahiro Ashizawa Chihiro Yamamoto Kaoru Hatano Kazuya Sato Ken Ohmine Shin-Ichiro Fujiwara Shun-Ichi Kimura Shinichi Kako Noriko Doki Yukiyasu Ozawa Yasuo Mori Tetsuya Eto Nobuhiro Hiramoto Hirohisa Nakamae Junya Kanda Tatsuo Ichinohe Yoshiko Atsuta Hideki Nakasone Satoko Morishima Yoshinobu Kanda

Blood 2023年6月

Chronic graft-versus-host disease (cGVHD) is a multiorgan syndrome with clinical features resembling those of autoimmune diseases. Thus, understanding commonalities in the pathophysiology of cGVHD and autoimmune diseases, such as the presence of d...

Impact of anti-thymocyte globulin on survival outcomes in female-to-male allogeneic hematopoietic stem cell transplantation

Masaharu Tamaki Yu Akahoshi Masahiro Ashizawa Yukiko Misaki Satoshi Koi Sung-Won Kim Yukiyasu Ozawa Shin-ichiro Fujiwara Shinichi Kako Ken-ichi Matsuoka Masashi Sawa Yuta Katayama Makoto Onizuka Yoshinobu Kanda Takahiro Fukuda Yoshiko Atsuta Kimikazu Yakushijin Hideki Nakasone

Scientific Reports 13(1) 2023年5月

Abstract

Allogeneic hematopoietic cell transplantation between female donors and male recipients (female-to-male allo-HCT) is a well-established risk factor for inferior survival outcomes due to a higher incidence of graft-versus-host disease (GV...

同種造血幹細胞移植後の抗MDA5抗体陽性急速進行性間質性肺疾患に有効であった3剤併用免疫抑制療法

中村侑平川村俊人松見信平松本和久田中里奈石川拓斗松岡あかり米野友啓河村匡捷竹下絢子吉野望吉村一樹三崎柚季子後明晃由美岡田陽介玉置雅治楠田待子赤星佑亀田和明和田英則木村俊一仲宗根秀樹賀古真一伊達洋至神田善伸

臨床血液 64(4) 250-254 2023年4月

34歳男性。KMT2A-MLLT1陽性急性骨髄性白血病の第1寛解期で,busulfan/高用量cyclophosphamideを前処置としてHLA適合の妹より同種末梢血幹細胞移植を施行した。Day14に生着し以降は寛解を維持した。重篤な移植片対宿主病も認めなかったが,経口cyclosporin(CsA)10mg/dayまで減量した移植後6ヶ月の時点で間質性肺炎を発症した。間質性肺炎に対して投与したprednisolone(PSL)の効果は一時的で,間質性肺炎は急速に増悪した。追加精査にて抗...