Jiaying Liu   Go Kasuya   Buntaro Zempo   Koichi Nakajo   
Frontiers in Physiology 13 2022年6月 [査読有り]
<jats:p>The HCN4 channel is essential for heart rate regulation in vertebrates by generating pacemaker potentials in the sinoatrial node. HCN4 channel abnormality may cause bradycardia and sick sinus syndrome, making it an important target for cli...
<title>Abstract</title>Modulation of voltage-gated potassium (Kv) channels by auxiliary subunits is central to the physiological function of channels in the brain and heart1,2. Native Kv4 tetrameric channels form macromolecular ternary ...