During periods of fasting, the body undergoes a metabolic shift from carbohydrate utilization to the use of fats and ketones as an energy source, as well as the inhibition of de novo lipogenesis and the initiation of gluconeogenesis in the liver. ...
Mild cognitive impairment (MCI) is not just a prodrome to dementia, but a very important intervention point to prevent dementia caused by Alzheimer's disease (AD). It has long been known that people with AD have a higher fr...
Zahra Mehrazad Saber Yoshinori Takeuchi Yoshikazu Sawada Yuichi Aita Man Hei Ho Samia Karkoutly Duhan Tao Kyoka Katabami Chen Ye Yuki Murayama Akito Shikama Yukari Masuda Yoshihiko Izumida Takafumi Miyamoto Takashi Matsuzaka Takehito Sugasawa Kazuhiro Takekoshi Yasushi Kawakami Hitoshi Shimano Naoya Yahagi
Biochemical and biophysical research communications 582 35-42 2021年12月 [査読有り]
High protein diet (HPD) is an affordable and positive approach in prevention and treatment of many diseases. It is believed that transcriptional regulation is responsible for adaptation after HPD feeding and Kruppel-like factor 15 (KLF15), a zinc ...
Yoshinori Takeuchi Naoya Yahagi Yuichi Aita Zahra Mehrazad-Saber Man Hei Ho Yiren Huyan Yuki Murayama Akito Shikama Yukari Masuda Yoshihiko Izumida Takafumi Miyamoto Takashi Matsuzaka Yasushi Kawakami Hitoshi Shimano
iScience 24(12) 103446-103446 2021年12月 [査読有り]
KLF15 is a transcription factor that plays an important role in the activation of gluconeogenesis from amino acids as well as the suppression of lipogenesis from glucose. Here we identified the transcription start site of liver-specific KLF15 tran...
The identification of upstream transcription factors regulating the expression of a gene is generally not an easy process. To facilitate this task, we constructed an expression cDNA library named Transcription Factor Expression Library (TFEL), wh...
自治医科大学
医学部