医学部臨床検査医学講座

水品佳子

研究者氏名	水品佳子
	ミズシナヨシコ
URL
所属	自治医科大学
部署	医学部臨床検査医学講座
職名	講師
J-Global ID	202001016285502357

研究キーワード

急性肺傷害

研究分野

ライフサイエンス / 呼吸器内科学 /

論文

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Caspase-11 deficiency attenuates neutrophil recruitment into the atherosclerotic lesion in apolipoprotein E-deficient mice.

Tadayoshi Karasawa Takanori Komada Chintogtokh Baatarjav Emi Aizawa Yoshiko Mizushina Kenta Fujimura Yoshitaka Gunji Satoko Komori Hidetoshi Aizawa Cantona Billton Jing Tao Takayoshi Matsumura Masafumi Takahashi

Biochemical and biophysical research communications 686 149158-149158 2023年12月

Caspase-11 is an inflammatory caspase that triggers an inflammatory response by regulating non-canonical NLRP3 inflammasome activation. Although the deficiency of both caspase-11 and caspase-1, another inflammatory caspase that functions as an exe...

NLRP3 inflammasome-driven IL-1β and IL-18 contribute to lipopolysaccharide-induced septic cardiomyopathy.

Kenta Fujimura Tadayoshi Karasawa Takanori Komada Naoya Yamada Yoshiko Mizushina Chintogtokh Baatarjav Takayoshi Matsumura Kinya Otsu Norihiko Takeda Hiroaki Mizukami Kazuomi Kario Masafumi Takahashi

Journal of molecular and cellular cardiology 180 58-68 2023年7月

Sepsis is a life-threatening syndrome, and its associated mortality is increased when cardiac dysfunction and damage (septic cardiomyopathy [SCM]) occur. Although inflammation is involved in the pathophysiology of SCM, the mechanism of how inflamm...

Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome.

Tadayoshi Karasawa Takanori Komada Naoya Yamada Emi Aizawa Yoshiko Mizushina Sachiko Watanabe Chintogtokh Baatarjav Takayoshi Matsumura Masafumi Takahashi

eLife 11 2022年5月

Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by mutations of NLRP3 gene encoding cryopyrin. Familial cold autoinflammatory syndrome, the mildest form of CAPS, is characterized by cold-induced inflammation in...

Immunoglobulin G4-related Pleuritis Complicated with Minimal Change Disease.

Yoshiko Mizushina Jun Shiihara Motoko Nomura Hiromitsu Ohta Fumiyoshi Ohyanagi Yoshiyuki Morishita Hiroyoshi Tsubochi Akira Tanaka Yasuhiro Yamaguchi

Internal medicine (Tokyo, Japan) 61(5) 723-728 2022年3月

A 70-year-old woman with bilateral pleural effusion and respiratory failure was admitted to our hospital. Nephrotic syndrome due to minimal change disease had been diagnosed four months before admission. Because blood tests and a pleural fluid ana...

Dramatic response to alectinib in a patient with ALK-rearranged squamous cell lung cancer.

Jun Shiihara Fumiyoshi Ohyanagi Hikari Amari Minemichi Toda Hiroki Tahara Motoi Yuzawa Yuki Maeda Motoko Nomura Yoshiko Mizushina Yoshiaki Nagai Hiromitsu Ohta Yasuhiro Yamaguchi

Thoracic cancer 12(17) 2420-2423 2021年9月

Lung cancers with anaplastic lymphoma kinase (ALK) rearrangements are highly sensitive to treatment with ALK tyrosine kinase inhibitors (TKIs). Due to the very low rate of patients with squamous cell carcinoma enrolled in clinical trials, the effi...

共同研究・競争的資金等の研究課題

急性肺傷害における炎症性細胞死Pyroptosisの機序と役割の解明
日本学術振興会: 科学研究費助成事業
水品佳子

研究期間: 2022年4月 - 2024年3月

肺線維症における無菌性炎症の分子基盤の解明
日本学術振興会: 科学研究費助成事業
水品佳子

研究期間: 2020年4月 - 2022年3月

急性肺傷害における無菌性炎症の分子基盤の解明
日本学術振興会: 科学研究費助成事業
水品佳子高橋将文

研究期間: 2016年8月 - 2018年3月

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医学部 臨床検査医学講座

水品 佳子

研究キーワード

研究分野

論文

共同研究・競争的資金等の研究課題

医学部臨床検査医学講座

水品佳子