Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, the organ-specific regulation mechanism is poorly understood. Here, we demonstrate 7-dehydrocholesterol reductase (DHCR7), the terminal ...
Biochemical and biophysical research communications 686 149158-149158 2023年12月
Caspase-11 is an inflammatory caspase that triggers an inflammatory response by regulating non-canonical NLRP3 inflammasome activation. Although the deficiency of both caspase-11 and caspase-1, another inflammatory caspase that functions as an exe...
Journal of molecular and cellular cardiology 180 58-68 2023年7月
Sepsis is a life-threatening syndrome, and its associated mortality is increased when cardiac dysfunction and damage (septic cardiomyopathy [SCM]) occur. Although inflammation is involved in the pathophysiology of SCM, the mechanism of how inflamm...
Takayoshi Matsumura Haruhito Totani Yoshitaka Gunji Masahiro Fukuda Rui Yokomori Jianwen Deng Malini Rethnam Chong Yang Tze King Tan Tadayoshi Karasawa Kazuomi Kario Masafumi Takahashi Motomi Osato Takaomi Sanda Toshio Suda
Nature Communications 13(1) 7064-7064 2022年11月
Abstract
The transcription factor MYB is a crucial regulator of hematopoietic stem and progenitor cells. However, the nature of lineage-specific enhancer usage of the Myb gene is largely unknown. We identify the Myb −68 enhancer, a regulatory ele...
American Journal of Human Genetics 93(2) 289-297 2013年8月
Takayasu arteritis (TAK) is an autoimmune systemic vasculitis of unknown etiology. Although previous studies have revealed that HLA-B*52:01 has an effect on TAK susceptibility, no other genetic determinants have been established so far. Here, we p...
Arteriosclerosis, thrombosis, and vascular biology 25(6) 1135-41 2005年6月 [査読有り]
The Krüppel-like factor (KLF) family is a recently highlighted group of zinc finger transcription factors given their important biological roles which include the vasculature. KLF2, KLF4, KLF5, and KLF6 are notable factors that have been implicate...
Trends in cardiovascular medicine 15(4) 125-9 2005年5月 [査読有り]
Transcriptional regulation in eukaryotes requires an understanding of the regulation of the chromatin structure. Chromatin is the eukaryotic-specific packaging/compaction of DNA with nucleosomal histones. This present review discusses recent advan...
自治医科大学
分子病態治療研究センター