Crystallin aggregation in the eye lens is involved in the pathogenesis of cataracts. The aggregation is considered to be promoted by non-enzymatic post-translational modifications, such as the deamidation and stereoinversion of amino acid residues...
Yuki Kitamura Shinji Oikawa Jie Chang Yurie Mori Gaku Ichihara Sahoko Ichihara
Antioxidants 12(4) 844-844 2023年3月 [査読有り]
Based on the known role of oxidative stress in the pathogenesis and progression of metabolic syndrome, we used two-dimensional gel electrophoresis with immunochemical detection of protein carbonyls (2D-Oxyblot) to characterize the carbonylated pro...
Diabetes mellitus (DM) is a pro-thrombotic state that can potentially cause serious cardiovascular complications. Platelet hyperactivation plays an important role in these pathological processes, however there is little or no information on the ef...
Yuki Kitamura Nathan Mise Yurie Mori Yuka Suzuki Tomoki Ohashi Saeko Tada-Oikawa Masaki Tokisu Cai Zong Shinji Oikawa Sahoko Ichihara
Scientific Reports 10(1) 2020年12月 [査読有り]
<title>Abstract</title>
Smoking increases the risk of cardiovascular diseases. The present study was designed to determine the effects of 2-month exposure to cigarette smoke (CS) on proteins in the left ventricles of spontaneously hypertensive ra...
自治医科大学
医学部