Proceedings of the National Academy of Sciences of the United States of America 115(4) 708-713 2018年1月 [査読有り]
Genetically engineered pigs play an indispensable role in the study of rare monogenic diseases. Pigs harboring a gene responsible for a specific disease can be efficiently generated via somatic cell cloning. The generation of somatic cell-cloned p...
Center for Development of Advanced Medical Technology (CDAMTec) in Jichi Medical University was established in 2009. It is the first educational research facility specialized for medical research and training using swine in Japan. Preclinical stud...
Pigs with X-linked severe combined immunodeficiency (X-SCID) caused by a mutation of the interleukin-2 receptor gamma chain gene (IL2RG) are of value for a wide range of studies. However, they do not survive longer than 8 weeks because of their su...
Naoki Osada Jiro Kikuchi Takashi Umehara Shin Sato Masashi Urabe Tomoyuki Abe Nakanobu Hayashi Masahiko Sugitani Yutaka Hanazono Yusuke Furukawa
Oncotarget 9(5) 6450-6462 2018年 [査読有り]
Human induced pluripotent stem cells (hiPSCs) are creating great expectations for regenerative medicine. However, safety strategies must be put in place to guard against teratoma formation after transplantation of hiPSC-derived cells into patients...
INTERNATIONAL JOURNAL OF HEMATOLOGY 106(5) 631-637 2017年11月 [査読有り]
We and others have reported that human hematopoietic stem cells (HSCs) are also present in the CD34-negative (CD34(-)) fraction of human cord blood (CB). Here, we examined the hematopoietic engraftment potential of 13 or 18 lineage-negative (13Lin...
自治医科大学
分子病態治療研究センター