Fuminori Tanihara   Maki Hirata   Zhao Namula   Lanh Thi Kim Do   Naoaki Yoshimura   Qingyi Lin   Koki Takebayashi   Tetsushi Sakuma   Takashi Yamamoto   Takeshige Otoi   
Frontiers in cell and developmental biology 11 884340 2023年 [査読有り]
Just one amino acid at the carboxy-terminus of the B chain distinguishes human insulin from porcine insulin. By introducing a precise point mutation into the porcine insulin (INS) gene, we were able to generate genetically modified pigs that secre...