研究者氏名	太田聡
	オオタサトシ
所属	自治医科大学
部署	医学部生化学講座構造生化学部門
職名	講師
学位	バイオサイエンス博士(奈良先端科学技術大学院大学)
J-Global ID	201401081432958696

研究キーワード

ST2 ,発がん ,転移 ,MerTK ,IL-33 ,Ras ,クロマトグラフィー ,キネトコア ,分子生物学 ,生化学 ,タンパク質 ,がん ,動原体 ,チェックポイント ,プロテオミクス ,染色体分配 ,染色体複製 ,DNA複製 ,プロテオーム ,質量分析 ,クロマチン ,細胞周期 ,染色体 ,シグナル伝達

研究分野

ライフサイエンス / 細胞生物学 /
ライフサイエンス / 分子生物学 /
ライフサイエンス / 医化学 /

論文

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Overexpression of satellite RNAs in heterochromatin induces chromosomal instability and reflects drug sensitivity in mouse cancer cells.

Sawako Tamaki Koichi Suzuki Iku Abe Yuhei Endo Nao Kakizawa Fumiaki Watanabe Masaaki Saito Shingo Tsujinaka Yasuyuki Miyakura Satoshi Ohta Kenji Tago Ken Yanagisawa Fumio Konishi Toshiki Rikiyama

Scientific reports 12(1) 10999-10999 2022年6月

Overexpression of satellite RNAs in heterochromatin induces chromosomal instability (CIN) through the DNA damage response and cell cycle checkpoint activation. Although satellite RNAs may be therapeutic targets, the associated mechanisms underlyin...

The role of MerTK in promoting cell migration is enhanced by the oncogenic Ras/IL‐33 signaling axis

Satoshi Ohta Kenji Tago Takahiro Kuchimaru Megumi Funakoshi‐Tago Hisanaga Horie Chihiro Aoki‐Ohmura Jitsuhiro Matsugi Ken Yanagisawa

The FEBS Journal 289(7) 1950-1967 2021年11月

Ras genes are frequently mutated in many cancer types; however, there are currently no conclusively effective anticancer drugs against Ras-induced cancer. Therefore, the downstream effectors of Ras signaling need to be identified for the developme...

K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors.

Kenji Tago Satoshi Ohta Chihiro Aoki-Ohmura Megumi Funakoshi-Tago Miho Sashikawa Takeshi Matsui Yuki Miyamoto Taeko Wada Tomoyuki Oshio Mayumi Komine Jitsuhiro Matsugi Yusuke Furukawa Mamitaro Ohtsuki Junji Yamauchi Ken Yanagisawa

Scientific reports 11(1) 20658-20658 2021年10月

NKIRAS1 and NKIRAS2 (also called as κB-Ras) were identified as members of the atypical RAS family that suppress the transcription factor NF-κB. However, their function in carcinogenesis is still controversial. To clarify how NKIRAS acts on cellula...

Production of capsid proteins of rat hepatitis E virus in Escherichia coli and characterization of self-assembled virus-like particles.

Tominari Kobayashi Masaharu Takahashi Satoshi Ohta Shigeo Nagashima Putu Prathiwi Primadharsini Mulyanto Satoshi Kunita Kazumoto Murata Hiroaki Okamoto

Virus research 302 198483-198483 2021年9月

Rat hepatitis E virus (HEV) has been isolated from wild rats worldwide and the potential of zoonotic transmission has been documented. Escherichia coli (E. coli) is utilized as an effective system for producing HEV-like particles. However, the pro...

ILDR2 stabilization is regulated by its interaction with GRP78.

Kazuhisa Watanabe Kazuhiro Nakayama Satoshi Ohta Ayumi Matsumoto Hidetoshi Tsuda Sadahiko Iwamoto

Scientific reports 11(1) 8414-8414 2021年4月

Ildr2 was initially identified as a genetic modifier of diabetes susceptibility in B6.DBA Lepob congenic mice, and was associated with decreased β-cell replication rates, reduced β-cell mass, and persistent mild hypoinsulinemic hyperglycemia. Howe...