研究者氏名	冨永薫
	トミナガカオル
URL	http://kaken.nii.ac.jp/d/r/20265242.ja.html
所属	自治医科大学
部署	医学部生化学講座構造生化学部門
職名	教授
学位	博士（医学）(自治医科大学)
J-Global ID	201401018168107794

研究キーワード

ミトコンドリア ,老化 ,代謝 ,エピジェネティクス ,ガン ,加齢 ,ヒストン修飾 ,幹細胞 ,クロマチン ,細胞老化 ,リポ多糖 ,C3H ,MAPキナーゼ ,IL-6 ,マクロファージ ,HeJマウス ,線維芽細胞 ,NF-κB ,感染防御 ,スカベンジャー受容体 ,LPS(リポ多糖) ,ノックアウトマウス

研究分野

12 >

ライフサイエンス / 栄養学、健康科学 / 加齢、老化
ライフサイエンス / 機能生物化学 / 代謝
ライフサイエンス / 神経科学一般 / 神経幹細胞
ライフサイエンス / 分子生物学 / エピジェネティクス、クロマチン
ライフサイエンス / ゲノム生物学 /

経歴

2022年4月

現在

自治医科大学医学部生化学講座構造生化学部門教授

2020年10月

2022年3月

自治医科大学医学部生化学講座機能生化学部門教授

2011年4月

2020年9月

自治医科大学医学部准教授

論文

12 3 4 5 >

Fatty Acids Play a Critical Role in Mitochondrial Oxidative Phosphorylation in Effector T Cells in Graft-versus-Host Disease.

Hirofumi Nakano Kazuya Sato Junko Izawa Norihito Takayama Hiroko Hayakawa Takashi Ikeda Shin-Ichiro Kawaguchi Kiyomi Mashima Kento Umino Kaoru Morita Ryoji Ito Nobuhiko Ohno Kaoru Tominaga Hitoshi Endo Yoshinobu Kanda

ImmunoHorizons 8(3) 228-241 2024年3月

Although the role of aerobic glycolysis in activated T cells has been well characterized, whether and how fatty acids (FAs) contribute to donor T cell function in allogeneic hematopoietic stem cell transplantation is unclear. Using xenogeneic graf...

Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells

Kaoru Tominaga Eiji Sakashita Katsumi Kasashima Kenji Kuroiwa Yasumitsu Nagao Naoki Iwamori Hitoshi Endo

International Journal of Molecular Sciences 24(3) 2113-2113 2023年1月 [査読有り]

Epigenetic regulation via epigenetic factors in collaboration with tissue-specific transcription factors is curtail for establishing functional organ systems during development. Brain development is tightly regulated by epigenetic factors, which a...

Dimethyl fumarate ameliorates graft‐versus‐host disease by inhibiting T‐cell metabolism and immune responses through a reactive oxygen species‐dependent mechanism

Kiyomi Mashima Kazuya Sato Takashi Ikeda Junko Izawa Norihito Takayama Hiroko Hayakawa Shin‐Ichiro Kawaguchi Hirofumi Nakano Takashi Nagayama Kento Umino Kaoru Morita Kaoru Tominaga Hitoshi Endo Yoshinobu Kanda

British Journal of Haematology 2022年2月 [査読有り]

Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo

Rintaro Kuroda Kaoru Tominaga Katsumi Kasashima Kenji Kuroiwa Eiji Sakashita Hiroko Hayakawa Tom Kouki Nobuhiko Ohno Kensuke Kawai Hitoshi Endo

PLOS ONE 16(7) e0255355-e0255355 2021年7月 [査読有り]

Mitochondrial dysfunction is significantly associated with neurological deficits and age-related neurological diseases. While mitochondria are dynamically regulated and properly maintained during neurogenesis, the manner in which mitochondrial act...

Mesenchymal Stromal Cells Inhibit Aerobic Glycolysis in Activated T Cells by Negatively Regulating Hexokinase II Activity Through PD-1/PD-L1 Interaction

Yasufumi Kawasaki Kazuya Sato Kiyomi Mashima Hirofumi Nakano Takashi Ikeda Kento Umino Kaoru Morita Junko Izawa Norihito Takayama Hiroko Hayakawa Kaoru Tominaga Hitoshi Endo Yoshinobu Kanda

TRANSPLANTATION AND CELLULAR THERAPY 27(3) 2021年3月 [査読有り]

Mesenchymal stromal cells (MSCs) have been shown to inhibit aerobic glycolysis in activated T cells, leading to increased autophagy. Although tryptophan depletion induced by indoleamine 2,3-dioxygenase (IDO) generated by MSCs has been suggested as...