研究者氏名	澤城大悟
	サワキダイゴ
URL
所属	自治医科大学
部署	医学部　薬理学講座　臨床薬理学部門
職名	講師
科研費研究者番号	40456132
ORCID ID	0000-0003-1417-2033
J-Global ID	202301010250577706

論文

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Multi-Omics of Familial Thoracic Aortic Aneurysm and Dissection: Calcium Transport Impairment Predisposes Aortas to Dissection.

Shota Tomida Tamaki Ishima Daigo Sawaki Yasushi Imai Ryozo Nagai Kenichi Aizawa

International journal of molecular sciences 24(20) 2023年10月

Several genetic defects, including a mutation in myosin heavy chain 11 (Myh11), are reported to cause familial thoracic aortic aneurysm and dissection (FTAAD). We recently showed that mice lacking K1256 of Myh11 developed aortic dissection when st...

Osteopontin promotes age-related adipose tissue remodeling through senescence-associated macrophage dysfunction.

Daigo Sawaki Yanyan Zhang Amel Mohamadi Maria Pini Zaineb Mezdari Larissa Lipskaia Suzain Naushad Lucille Lamendour Dogus Murat Altintas Marielle Breau Hao Liang Maissa Halfaoui Thaïs Delmont Mathieu Surenaud Déborah Rousseau Takehiko Yoshimitsu Fawzia Louache Serge Adnot Corneliu Henegar Philippe Gual Gabor Czibik Geneviève Derumeaux

JCI insight 8(8) 2023年4月

Adipose tissue macrophages (ATMs) play an important role in obesity and inflammation, and they accumulate in adipose tissue (AT) with aging. Furthermore, increased ATM senescence has been shown in obesity-related AT remodeling and dysfunction. How...

Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging.

Gabor Czibik Zaineb Mezdari Dogus Murat Altintas Juliette Bréhat Maria Pini Thomas d'Humières Thaïs Delmont Costin Radu Marielle Breau Hao Liang Cecile Martel Azania Abatan Rizwan Sarwar Ophélie Marion Suzain Naushad Yanyan Zhang Maissa Halfaoui Nadine Suffee Didier Morin Serge Adnot Stéphane Hatem Arash Yavari Daigo Sawaki Geneviève Derumeaux

Circulation 144(7) 559-574 2021年8月

BACKGROUND: Aging myocardium undergoes progressive cardiac hypertrophy and interstitial fibrosis with diastolic and systolic dysfunction. Recent metabolomics studies shed light on amino acids in aging. The present study aimed to dissect how aging ...

Adipose tissue senescence is mediated by increased ATP content after a short-term high-fat diet exposure.

Maria Pini Gabor Czibik Daigo Sawaki Zaineb Mezdari Laura Braud Thaïs Delmont Raquel Mercedes Cécile Martel Nelly Buron Geneviève Marcelin Annie Borgne-Sanchez Roberta Foresti Roberto Motterlini Corneliu Henegar Geneviève Derumeaux

Aging cell 20(8) e13421 2021年8月

In the context of obesity, senescent cells accumulate in white adipose tissue (WAT). The cellular underpinnings of WAT senescence leading to insulin resistance are not fully elucidated. The objective of the current study was to evaluate the presen...

Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction.

Nathalie Mougenot Delphine Mika Gabor Czibik Elizabeth Marcos Shariq Abid Amal Houssaini Benjamin Vallin Aziz Guellich Hind Mehel Daigo Sawaki Grégoire Vandecasteele Rodolphe Fischmeister Roger J Hajjar Jean-Luc Dubois-Randé Isabelle Limon Serge Adnot Geneviève Derumeaux Larissa Lipskaia

Cardiovascular research 115(12) 1778-1790 2019年10月

AIMS: Increase of cardiac cAMP bioavailability and PKA activity through adenylyl-cyclase 8 (AC8) overexpression enhances contractile function in young transgenic mice (AC8TG). Ageing is associated with decline of cardiac contraction partly by the ...