INTRODUCTION: The Hippo pathway consists of mammalian sterile 20-like kinase 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and yes-associated protein (YAP)1. Herein, we present the first report on the significance of major Hippo pathway prot...
Virchows Archiv : an international journal of pathology 2023年9月
The present study immunohistochemically investigated trimethylation of lysine 27 of histone 3 (H3K27me3) expression in 769 endometrial carcinomas and 196 uterine mesenchymal tumors. One dedifferentiated endometrial carcinoma (DEC) and one carcinos...
Laura D Wood N Volkan Adsay Olca Basturk Lodewijk A A Brosens Noriyoshi Fukushima Seung-Mo Hong Sung-Joo Kim Jae W Lee Claudio Luchini Michaël Noë Martha B Pitman Aldo Scarpa Aatur D Singhi Mariko Tanaka Toru Furukawa
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2023年8月
BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, and pathological examina...
A 61-year-old woman was administered 35 cycles of pembrolizumab for the treatment of recurrent endometrial cancer, achieving a complete response. She presented with asymptomatic pancreatic enlargement and elevated hepatobiliary enzymes, but amylas...
Kiri Koshu Kazuhiro Muramatsu Tomomi Maru Yoshie Kurokawa Yoshitaka Mizobe Hirokazu Yamagishi Daisuke Matsubara Koji Yokoyama Eriko Jimbo Hideki Kumagai Yukihiro Sanada Yasunaru Sakuma Noriyoshi Fukushima Aya Narita Takanori Yamagata Hitoshi Osaka
Brain & development 2023年7月
BACKGROUND: Niemann-Pick disease type C (NPC) is an autosomal recessive inherited and neurodegenerative disorder. Approximately 10% of NPC patients have acute liver failure and sometimes need liver transplantation (LT), and 7% reportedly develop i...
改訂された膵癌取扱い規約第8版において,膵癌に対する薬物・放射線治療後の組織学的効果判定基準については,前版で提示した「生存し得ると判断される癌細胞の残存率を目安に行う」独自の分類システムを継承しつつ,国際動向もにらみCAP(College of American Pathologists)システムの併記を推奨した。両システムの違いは,規約システムが,残存した腫瘍量の割合を評価の軸にした「相対的評価」であるのに対し,CAPシステムでは,残存腫瘍にフォーカスした「絶対的評価」に近いシステムで...
自治医科大学
附属病院