糟谷豪

研究者氏名	糟谷豪

URL	https://scholar.google.co.jp/citations?user=ZKiWyWgAAAAJ&hl=ja&oi=sra
所属	自治医科大学
部署	医学部生理学講座　統合生理学部門
職名	講師
学位	博士（理学）(東京大学)
科研費研究者番号	80845115
ORCID ID	0000-0003-1756-5764
J-Global ID	201901003448115571

研究キーワード

電気生理学 ,構造生物学 ,電子顕微鏡 ,イオンチャネル

研究分野

ライフサイエンス / 医療薬学 /
ライフサイエンス / 生理学 /
ライフサイエンス / 生物物理学 /
ライフサイエンス / 構造生物化学 /

経歴

2024年4月

現在

自治医科大学医学部生理学講座統合生理学部門講師

2019年4月

2024年3月

自治医科大学医学部生理学講座統合生理学部門助教

学歴

2018年3月

東京大学大学院理学系研究科生物科学専攻博士課程

委員歴

2023年3月

現在

日本生理学会評議員

論文

12 3 >

Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex

Daichi Yamanouchi Go Kasuya Koichi Nakajo Yoshiaki Kise Osamu Nureki

Molecular Cell 2023年11月 [査読有り]

Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1-KCNE3 channel complex

Go Kasuya Koichi Nakajo

eLife 2022年11月 [査読有り]

Two HCN4 Channels Play Functional Roles in the Zebrafish Heart

Jiaying Liu Go Kasuya Buntaro Zempo Koichi Nakajo

Frontiers in Physiology 13 2022年6月 [査読有り]

The HCN4 channel is essential for heart rate regulation in vertebrates by generating pacemaker potentials in the sinoatrial node. HCN4 channel abnormality may cause bradycardia and sick sinus syndrome, making it an important target for clinical re...

Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1

Tatsuya Hagino Takafumi Kato Go Kasuya Kan Kobayashi Tsukasa Kusakizako Shin Hamamoto Tomoaki Sobajima Yuichiro Fujiwara Keitaro Yamashita Hisashi Kawasaki Andrés D. Maturana Tomohiro Nishizawa Osamu Nureki

Nature Communications 13(1) 2022年5月 [査読有り]

Abstract

In the light reaction of plant photosynthesis, modulation of electron transport chain reactions is important to maintain the efficiency of photosynthesis under a broad range of light intensities. VCCN1 was recently identified as a voltag...

Structural basis of gating modulation of Kv4 channel complexes

Yoshiaki Kise Go Kasuya Hiroyuki H. Okamoto Daichi Yamanouchi Kan Kobayashi Tsukasa Kusakizako Tomohiro Nishizawa Koichi Nakajo Osamu Nureki

Nature 599(7883) 158-164 2021年9月 [査読有り]

<title>Abstract</title>Modulation of voltage-gated potassium (Kv) channels by auxiliary subunits is central to the physiological function of channels in the brain and heart^1,2. Native Kv4 tetrameric channels form macromolecular ternary ...

MISC

Modulation of potassium channels by transmembrane auxiliary subunits via voltage‐sensing domains

Koichi Nakajo Go Kasuya

Physiological Reports 12(6) 2024年3月 [査読有り][招待有り]

Abstract

Voltage‐gated K⁺ (K_V) and Ca²⁺‐activated K⁺ (K_Ca) channels are essential proteins for membrane repolarization in excitable cells. They also play important physiological roles in non‐...

Recent Advances in the Structural Biology of the Volume-Regulated Anion Channel LRRC8

Go Kasuya Osamu Nureki

Frontiers in Pharmacology 13 2022年5月 [査読有り][招待有り]

Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed of five LRRC8A-E isoforms, are pore-forming components of the volume-regulated anion channel (VRAC), which is activated by cell swelling and releases chloride ions (C...

Structural insights into divalent cation modulations and ligand specificity of ATP-gated P2X receptor channels

Yuichiro Fujiwara Go Kasuya Motoyuki Hattori Osamu Nureki

Journal of Physiological Sciences 66(Supplement1) S66 2016年 [査読有り]

1P034 H+/Ca2交換輸送体における対向輸送の分子基盤(01B. 蛋白質:構造機能相関,ポスター,日本生物物理学会年会第51回(2013年度))

53(supplement1-2) S111-S111 2013年