医学部 解剖学講座

野田 泰子

ノダ ヤスコ  (Yasuko Noda)

基本情報

所属
自治医科大学 医学部解剖学講座 解剖学部門 教授
学位
医学博士(東京大学)

J-GLOBAL ID
201401064473644084
researchmap会員ID
B000238453

外部リンク

学歴

 2

論文

 31
  • Mochizuki S, Miki H, Zhou R, Kido Y, Nishimura W, Kikuchi M, Noda Y
    Experimental cell research 370(2) 601-612 2018年9月  査読有り
  • Nishimura, Wataru, Sakaue-Sawano, Asako, Takahashi, Satoru, Miyawaki, Atsushi, Yasuda, Kazuki, Noda, Yasuko
    Islets 10(3) 2018年4月  査読有り
    Glucose metabolism is regulated by insulin, which is produced from β-cells in the pancreas. Because insulin is secreted into vessels in response to blood glucose, vascular structures of the pancreas, especially the relationship between vessels and β-cells, are important for physiological and pathological glucose metabolism. Here, we developed a system to visualize vessels surrounding mature β-cells expressing transcription factor MafA in a three-dimensional manner. Optical clearing of the pancreas prevented light scattering of fluorescence driven by the bacterial artificial chromosome (BAC)-mafA promoter in β-cells. Reconstruction of confocal images demonstrated mature β-cells and the glomerular-like structures of β-cell vasculatures labeled with DyLight 488-conjugated lectin in normal mice as well as in low-dose streptozotocin-injected diabetes model mice with reduced β-cell mass. This technological innovation of organ imaging can be used to investigate morphological changes in vascular structures during transplantation, regeneration and diabetes development.
  • Hideyuki Ohzawa, Atsushi Miki, Takumi Teratani, Satomi Shiba, Yasunaru Sakuma, Wataru Nishimura, Yasuko Noda, Noriyoshi Fukushima, Hirofumi Fujii, Yasuo Hozumi, Hirofumi Mukai, Yoshikazu Yasuda
    ONCOLOGY LETTERS 13(3) 1731-1740 2017年3月  査読有り
    Pathological complete response (pCR) is considered to be a useful prognostic marker for neoadjuvant chemotherapy to improve the survival rate of patients with operable breast cancer. In the present study, we identified differentially expressed microRNAs (miRNAs) between pCR and non-pCR groups of patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer who received neoadjuvant chemotherapy with trastuzumab. Expression profiles were examined by miRNA microarrays using total RNA extracted from formalin-fixed, paraffin-embedded tissues from pretreatment biopsy specimens. Significant differences were observed in miRNAs associated with pCR between the luminal B-like (HER2-positive) and HER2posi-tive (nonluminal) subtypes, which were further classified according to their estrogen receptor (ER) status. Prediction models constructed with differentially expressed miRNAs performed well. In conclusion, the combination of miRNA profiles and ER status may improve the accuracy of pCR prediction in patients with HER2-positive breast cancer and enable the development of personalized treatment regimens.
  • Oe Souichi, Miki Harukata, Nishimura Wataru, Noda Yasuko
    Cell Structure and Function 41(1) 23-31 2016年  査読有り
    Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor critical for synaptic plasticity, neuronal development and neurite extension. BDNF mRNA is transported to dendrites and axons, where it is expressed locally. We previously reported that dendritic targeting elements in the BDNF 3' UTR are necessary for dendritic transport and interact with cytoplasmic polyadenylation element binding
  • Nishimura W, Ishibashi N, Eto K, Funahashi N, Udagawa H, Miki H, Oe S, Noda Y, Yasuda K
    Journal of molecular endocrinology 55(1) 31-40 2015年6月  査読有り

MISC

 6

書籍等出版物

 1

担当経験のある科目(授業)

 5