研究者業績

山名 隼人

Hayato Yamana

基本情報

所属
自治医科大学 データサイエンスセンター 講師
国立病院機構本部 総合研究センター診療情報分析部 非常勤研究員
東京大学 臨床疫学・経済学 非常勤講師

researchmap会員ID
R000011081

論文

 139
  • Satoko Kameda, Hayato Yamana, Yusuke Sasabuchi, Nobuaki Michihata, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Takahide Kohro
    Pediatric neurology 164 97-104 2025年3月  
    BACKGROUND: The benefit of early corticosteroid use in pediatric bacterial meningitis is uncertain, except for its effect on hearing loss caused by Haemophilus influenzae type b (Hib) meningitis. We aimed to evaluate the association between early corticosteroid use and the short-term outcomes amid a background of decreased Hib infection incidence. METHODS: We conducted a retrospective cohort study using data from a nationwide inpatient database in Japan. We identified children younger than 15 years with bacterial meningitis who were discharged between April 2014 and March 2022. The primary outcome was a composite of in-hospital death and neurological sequelae, defined as tracheostomy during hospitalization or disturbed consciousness, mechanical ventilation, tube feeding, or antiepileptic drugs at discharge. The secondary outcome was a recorded diagnosis of hearing loss. Stabilized inverse probability of treatment weighting using propensity scores was performed to compare the outcomes between patients with and without intravenous corticosteroid use on the day of admission. RESULTS: Of the 1310 eligible patients, 454 (35%) received early corticosteroids. Overall, 170 patients (13%) had composite outcomes, including seven deaths (0.5%). Hearing loss was observed in seven patients. After propensity score weighting, no significant difference was observed between patients with and without early corticosteroid use in the composite outcome (14.2% vs 13.5%, respectively; risk difference: 0.7%; 95% confidence interval: -3.3% to 4.6%) or hearing loss (0.7% vs 0.5%, respectively; risk difference: 0.2%; 95% confidence interval: -0.7% to 1.2%). CONCLUSIONS: Early corticosteroid use in children with bacterial meningitis was not associated with reduced deaths or neurological sequelae.
  • Sachiko Ono, Mikio Nakajima, Hayato Yamana, Nobuaki Michihata, Kohei Uemura, Yosuke Ono, Hideo Yasunaga
    Vaccine 49 126812-126812 2025年1月31日  
    Tetanus remains a major global health issue in both developing and developed countries. Although guidelines are established on tetanus prophylaxis protocol for trauma patients, adherence to tetanus vaccination is unknown. In this study, we aimed to investigate the administration of tetanus toxoid among trauma patients in Japan, where approximately 100 patients are hospitalized for tetanus annually. Using the JMDC claims database, a large administrative claims database, we identified outpatients with trauma between 2005 and 2020. We divided them into those born before 1968 and those born in 1968 or later, as the routine tetanus immunization program started in 1968 in Japan. We described the characteristics of the patients and whether they received the first dose of tetanus toxoid when they visited a medical institution for any injury. Finally, we followed up the patients who received the first tetanus toxoid dose and had a history of incomplete primary vaccination series to examine whether they completed the recommended three doses of tetanus immunization within 12 months. We identified 85,761 trauma patients from the database, of whom 19,541 (22.8 %) were born before 1968 and not covered by the routine vaccination program. Among the patients covered by the routine vaccination program, 2.1 % (1400/66,220) received tetanus toxoid vaccination at the initial clinic/hospital visit for their injuries, whereas the proportion was 5.8 % (1139/19,541) in the patients not covered by the routine vaccination program. Among the 1139 patients who received tetanus prophylaxis at the time of wound management and were born before the implementation of the routine vaccination program, 31.4 % received the second dose, and 7.0 % completed the third dose within 12 months. Taken together, most trauma patients without a history of primary tetanus immunization did not receive the recommended tetanus prophylaxis. Increased awareness of tetanus prophylaxis is needed among both patients and healthcare professionals.
  • Hiroyuki Ohbe, Nobuaki Shime, Hayato Yamana, Tadahiro Goto, Yusuke Sasabuchi, Daisuke Kudo, Hiroki Matsui, Hideo Yasunaga, Shigeki Kushimoto
    Journal of intensive care 12(1) 54-54 2024年12月23日  
  • Akira Okada, Hayato Yamana, Hideaki Watanabe, Katsunori Manaka, Sachiko Ono, Kayo Ikeda Kurakawa, Masako Nishikawa, Makoto Kurano, Reiko Inoue, Hideo Yasunaga, Toshimasa Yamauchi, Takashi Kadowaki, Satoko Yamaguchi, Masaomi Nangaku
    Clinical kidney journal 17(12) sfae319 2024年12月  
    BACKGROUND AND HYPOTHESIS: We aimed to evaluate the diagnostic validity of the International Classification of Diseases, 10th Revision (ICD-10) codes for hyponatremia and hypernatremia, using a database containing laboratory data. We also aimed to clarify whether corrections for blood glucose, triglyceride, and total protein may affect the prevalence and the diagnostic validity. METHODS: We retrospectively identified admissions with laboratory values using a Japanese hospital-based database. We calculated the sensitivity, specificity, and positive/negative predictive values of recorded ICD-10-based diagnoses of hyponatremia (E87.1) and hypernatremia (E87.2), using serum sodium measurements during hospitalization (<135 and >145 mmol/l, respectively) as the reference standard. We also performed analyses with corrections of sodium concentrations for blood glucose, triglyceride, and total protein. RESULTS: We identified 1 813 356 hospitalizations, including 419 470 hyponatremic and 132 563 hypernatremic cases based on laboratory measurements, and 18 378 hyponatremic and 2950 hypernatremic cases based on ICD-10 codes. The sensitivity, specificity, positive predictive value, and negative predictive value of the ICD-10 codes were 4.1%, 99.9%, 92.5%, and 77.6%, respectively, for hyponatremia and 2.2%, >99.9%, 96.5%, and 92.8%, respectively, for hypernatremia. Corrections for blood glucose, triglyceride, and total protein did not largely alter diagnostic values, although prevalence changed especially after corrections for blood glucose and total protein. CONCLUSIONS: The ICD-10 diagnostic codes showed low sensitivity, high specificity, and high positive predictive value for identifying hyponatremia and hypernatremia. Corrections for glucose or total protein did not affect diagnostic values but would be necessary for accurate prevalence calculation.
  • Chanon Nusawat, So Sato, Hideaki Watanabe, Takaaki Konishi, Hayato Yamana, Hideo Yasunaga
    Clinical Drug Investigation 2024年11月7日  

MISC

 15

書籍等出版物

 3

講演・口頭発表等

 83

担当経験のある科目(授業)

 5

所属学協会

 4

共同研究・競争的資金等の研究課題

 2