研究者業績

仲矢 丈雄

ナカヤ タケオ  (Takeo Nakaya)

基本情報

所属
自治医科大学 医学部病理学講座 人体病理学部門 准教授
学位
博士(医学)(東京大学)

研究者番号
80512277
J-GLOBAL ID
201501007018614597
researchmap会員ID
B000247321

外部リンク

2015年4月~ 自治医科大学 医学部・大学院医学研究科 講師

主要な論文

 37
  • Takeo Nakaya, Seishi Ogawa, Ichiro Manabe, Masami Tanaka, Masashi Sanada, Toshiro Sato, Makoto M. Taketo, Kazuki Nakao, Hans Clevers, Masashi Fukayama, Masahiko Kuroda, Ryozo Nagai
    CANCER RESEARCH 74(10) 2882-2891 2014年5月  査読有り
    The intestinal epithelium maintains homeostasis by a self-renewal process involving resident stem cells, including Lgr5(+) crypt-base columnar cells, but core mechanisms and their contributions to intestinal cancer are not fully defined. In this study, we examined a hypothesized role for KLF5, a zinc-finger transcription factor that is critical to maintain the integrity of embryonic and induced pluripotent stem cells, in intestinal stem-cell integrity and cancer in the mouse. Klf5 was indispensable for the integrity and oncogenic transformation of intestinal stem cells. In mice, inducible deletion of Klf5 in Lgr5(+) stem cells suppressed their proliferation and survival in a manner associated with nuclear localization of beta-catenin (Catnb), generating abnormal apoptotic cells in intestinal crypts. Moreover, production of lethal adenomas and carcinomas by specific expression of an oncogenic mutant of beta-catenin in Lgr5(+) stem cells was suppressed completely by Klf5 deletion in the same cells. Given that activation of the Wnt/beta-catenin pathway is the most frequently altered pathway in human colorectal cancer, our results argue that KLF5 acts as a fundamental core regulator of intestinal oncogenesis at the stem-cell level, and they suggest KLF5 targeting as a rational strategy to eradicate stem-like cells in colorectal cancer. (C) 2014 AACR.

MISC

 3

書籍等出版物

 4

講演・口頭発表等

 4

担当経験のある科目(授業)

 1

共同研究・競争的資金等の研究課題

 11