研究者業績

三木 厚

ミキ アツシ  (Atsushi Miki)

基本情報

所属
自治医科大学 医学部 外科学講座 消化器一般移植外科学部門 講師
学位
医学博士(岡山大学)

研究者番号
20570378
J-GLOBAL ID
201401083701983832
researchmap会員ID
B000238645

外部リンク

学歴

 2

論文

 163
  • Hideyuki Ohzawa, Kentaro Kurashina, Atsushi Miki, Yasunari Okuda, Misuzu Mori, Masuzu Ueda, Yoshinori Hosoya, Joji Kitayama, Naohiro Sata, Hirofumi Fujii
    ANNALS OF ONCOLOGY 27 2016年7月  
  • 笠原 尚哉, 寺谷 工, 横田 真一郎, 三木 厚, 浦橋 泰然, 藤本 康弘, 佐久間 康成, 佐田 尚宏
    日本消化器外科学会総会 71回 WS7-1 2016年7月  
  • 森本 光昭, 佐久間 康成, 笹沼 秀紀, 小泉 大, 遠藤 和洋, 三木 厚, 北山 丈二, アラン・レフォー, 佐田 尚宏
    日本肝胆膵外科学会・学術集会プログラム・抄録集 28回 565-565 2016年6月  
  • 湯澤 真梨子, 三木 厚, 利府 和馬, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    栃木県医学会々誌 46 49-51 2016年6月  
  • 眞田 幸弘, 浦橋 泰然, 井原 欣幸, 山田 直也, 岡田 憲樹, 平田 雄大, 片野 匠, 三木 厚, 笹沼 英紀, 佐久間 康成, 佐田 尚宏, 水田 耕一
    日本肝胆膵外科学会・学術集会プログラム・抄録集 28回 473-473 2016年6月  
  • 小泉 大, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 佐田 尚宏
    手術 70(7) 985-989 2016年6月  
  • Y. Sakuma, H. Sasanuma, A. Miki, A. Shimizu, N. Sata, Y. Yasuda, A. K. Lefor, Y. Hirata, N. Yamada, N. Okada, Y. Sanada, Y. Ihara, T. Urahashi, K. Mizuta
    Transplantation Proceedings 48(4) 1110-1114 2016年5月1日  査読有り
  • 小泉 大, 田口 昌延, 三木 厚, 遠藤 和洋, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本外科学会定期学術集会抄録集 116回 PS-4 2016年4月  
  • 湯澤 真梨子, 三木 厚, 利府 数馬, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本外科学会定期学術集会抄録集 116回 RS-5 2016年4月  
  • K Nanmoku, N Ishikawa, A Kurosawa, T Shimizu, T Kimura, A Miki, Y Sakuma, T Yagisawa
    Transplant infectious disease : an official journal of the Transplantation Society 18(2) 234-9 2016年4月  
    BACKGROUND: Urinary tract infection caused by human adenovirus (HAdV) after renal transplantation (RT) results in graft loss because of concomitant nephropathy and acute rejection and may result in death because of systemic dissemination. METHODS: We assessed the time period between RT and disease onset, symptoms, treatment details, disease duration, renal graft function, outcomes, and complications. RESULTS: HAdV infection of the urinary tract occurred in 8 of 170 renal transplant recipients. Symptoms were macrohematuria in all 8 patients, dysuria in 7, and fever in 5. The median period from RT to disease onset was 367 (range, 7-1763) days, and the median disease duration was 15 (range, 8-42) days. The mean serum creatinine (sCr) level prior to onset was 1.35 ± 0.48 mg/dL and the mean maximum sCr level during disease was 2.34 ± 1.95 mg/dL. These values were increased by ≥25% in 5 patients. The mean sCr levels when symptoms resolved was 1.54 ± 0.67 mg/dL, and no significant difference was seen before, during, or after disease onset (P = 0.069). Two patients were diagnosed with HAdV viremia and 1 with acute tubulointerstitial nephritis revealed on biopsy. In addition to a reduction in immunosuppressant dosage, 2 patients received gammaglobulins and 5 received ganciclovir. CONCLUSION: Symptoms of all patients were alleviated, although some patients developed nephritis or viremia. Hence, the possibility of exacerbation should always be considered. Adequate follow-up observation should be conducted, and diligent and aggressive therapeutic intervention is required to prevent the condition from worsening.
  • 芝 聡美, 三木 厚, 大澤 英之, 寺谷 工, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本外科学会定期学術集会抄録集 116回 OP-5 2016年4月  
  • 倉科 憲太郎, 三木 厚, 松本 健司, 村越 美穂, 佐藤 敏子, 小暮 亜弥子, 齋藤 心, 鯉沼 広治, 笹沼 英紀, 小泉 大, 佐久間 康成, 堀江 久永, 細谷 好則, 佐田 尚宏
    日本外科学会定期学術集会抄録集 116回 PS-3 2016年4月  
  • 倉科 憲太郎, 細谷 好則, 齋藤 心, 松本 志郎, 小暮 亜弥子, 佐藤 敏子, 村越 美穂, 荒川 由起子, 岡田 憲樹, 春田 英律, 宇井 崇, 三木 厚, 堀江 久永, 佐久間 康成, 佐田 尚宏
    日本胃癌学会総会記事 88回 344-344 2016年3月  
  • 倉科 憲太郎, 細谷 好則, 小暮 亜弥子, 村越 美穂, 佐藤 敏子, 荒川 由起子, 齋藤 心, 松本 志郎, 春田 英律, 宇井 崇, 三木 厚, 佐久間 康成, 堀江 久永, 佐田 尚宏
    日本静脈経腸栄養学会雑誌 31(1) 326-326 2016年1月  
  • 三木 厚, 佐久間 康成, 大澤 英之, 芝 聡美, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐田 尚宏
    胆膵の病態生理 = The Japanese journal of bilio-pancreatic pathophysiology 32(1) 35-37 2016年  
  • A. Miki, Y. Sakuma, H. Sasanuma, M. Koizumi, K. Endo, N. Sata
    PANCREAS 44(8) 1398-1398 2015年11月  
  • 吉田 淳, 佐久間 康成, 森嶋 計, 笠原 尚哉, 三木 厚, 笹沼 英紀, 佐田 尚宏, 安田 是和
    日本消化器外科学会雑誌 48(Suppl.2) 279-279 2015年10月  
  • 三木 厚, 佐久間 康成, 遠藤 和洋, 小泉 大, 笹沼 秀紀, 佐田 尚宏
    胆道 29(3) 553-553 2015年8月  
  • 吉田 淳, 佐久間 康成, 森嶋 計, 笠原 尚哉, 三木 厚, 笹沼 英紀, 佐田 尚宏, 安田 是和
    小切開・鏡視外科学会雑誌 6(1) 45-50 2015年8月  
  • 佐田 尚宏, 鈴木 正徳, 三木 厚, 小泉 大, 笹沼 英紀, 佐久間 康成
    手術 69(9) 1339-1344 2015年8月  
  • 笠原 尚哉, 寺谷 工, 三木 厚, 佐久間 康成, 藤本 康弘, 上本 伸二, 佐田 尚宏, 安田 是和
    日本消化器外科学会総会 70回 P-8 2015年7月  
  • 三木 厚, 佐久間 康成, 森嶋 計, 笹沼 秀紀, 佐田 尚宏, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集 27回 545-545 2015年6月  
  • 清水 敦, 遠藤 和洋, 三木 厚, 小泉 大, 笹沼 英紀, 佐久間 康成, 鈴木 正徳, 佐田 尚宏
    肝・胆・膵 70(6) 901-906 2015年6月  
  • 高橋 和也, 三木 厚, 佐田 尚宏, 佐久間 康成, 笠原 尚哉, 森嶋 計, 安田 是和
    膵臓 30(3) 404-404 2015年5月  
  • 三木 厚, 佐久間 康成, 森嶋 計, 笠原 尚哉, 笹沼 英紀, 佐田 尚宏, 安田 是和
    日本外科学会定期学術集会抄録集 115回 OP-8 2015年4月  
  • 眞田 幸弘, 川野 陽一, 三木 厚, 相田 順子, 仲村 賢一, 下村 七生貴, 石川 直, 新井 冨生, 平田 雄大, 山田 直也, 岡田 憲樹, 井原 欣幸, 浦橋 泰然, 安田 是和, 田久保 海誉, 水田 耕一
    日本外科学会定期学術集会抄録集 115回 OP-5 2015年4月  
  • 笠原 尚哉, 寺谷 工, 三木 厚, 佐久間 康成, 藤本 康弘, 上本 伸二, 佐田 尚宏, 安田 是和
    日本消化器病学会雑誌 112(臨増総会) A394-A394 2015年3月  
  • Atsushi Miki, Yasunaru Sakuma, Hideyuki Ohzawa, Yukihiro Sanada, Hideki Sasanuma, Alan T Lefor, Naohiro Sata, Yoshikazu Yasuda
    International surgery 100(3) 480-5 2015年3月  査読有り
    We report a rare case of immunoglobulin G4 (IgG4)-related sclerosing cholangitis without other organ involvement. A 69-year-old-man was referred for the evaluation of jaundice. Computed tomography revealed thickening of the bile duct wall, compressing the right portal vein. Endoscopic retrograde cholangiopancreatography showed a lesion extending from the proximal confluence of the common bile duct to the left and right hepatic ducts. Intraductal ultrasonography showed a bile duct mass invading the portal vein. Hilar bile duct cancer was initially diagnosed and percutaneous transhepatic portal vein embolization was performed, preceding a planned right hepatectomy. Strictures persisted despite steroid therapy. Therefore, partial resection of the common bile duct following choledochojejunostomy was performed. Histologic examination showed diffuse and severe lymphoplasmacytic infiltration, and abundant plasma cells, which stained positive for anti-IgG4 antibody. The final diagnosis was IgG4 sclerosing cholangitis. Types 3 and 4 IgG4 sclerosing cholangitis remains a challenge to differentiate from cholangiocarcinoma. A histopathologic diagnosis obtained with a less invasive approach avoided unnecessary hepatectomy.
  • Hideyuki Ohzawa, Atsushi Miki, Yasuo Hozumi, Chieko Miyazaki, Yuka Sagara, Yumiko Tanaka, Satomi Shiba, Hiromi Joutoku, Masako Sakuragi, Megumi Takehara, Yasunaru Sakuma, Wataru Nishimura, Hirofumi Fujii, Yoshikazu Yasuda
    Oncology letters 9(1) 119-124 2015年1月  
    Chemotherapy-induced nausea and vomiting is a serious adverse side-effect of anthracycline-based chemotherapy regimens, in patients with breast cancer. A combination of three drugs, 5-hydroxytryptamine (5-HT3) receptor antagonist, aprepitant and dexamethasone, is recommended for antiemetic therapy. Palonosetron (PALO), a novel 5-HT3 receptor antagonist has been identified to be effective against delayed nausea and vomiting. In this study, the results of PALO for patients who received anthracycline-based chemotherapy were compared with that of granisetron (GRA) using a crossover study design. This study evaluated the efficacy of antiemetics in the first cycle of chemotherapy, as well as the second and third cycles. A total of 21 patients and 19 patients were assigned to PALO and GRA treatment groups during the first cycle of chemotherapy, respectively. The patients switched to the other antiemetic drug for the second chemotherapy cycle (PALO followed by GRA or GRA followed by PALO). The patients could select PALO or GRA antiemetics for the third cycle, according to their preference. A total of 21 patients selected PALO and 18 patients selected GRA in the third cycle, and one patient was withdrawn from the study as their third cycle questionnaire was not obtained. No significant differences between PALO and GRA were identified in first and second cycles. However, during the third cycle, a significant difference was observed in acute-phase complete control of emetic events between the PALO and GRA groups, which was defined as no emetic episode, no additional antiemetic treatment and no more than mild nausea, between PALO and GRA. These results demonstrated that changing antiemetics may affect the efficacy of antiemetics. This study indicates that alteration of antiemetic regimens, including drug combination and order, may improve the efficacy of antiemetic treatment.
  • Atsushi Miki, Camillo Ricordi, Toshiyuki Yamamoto, Yasunaru Sakuma, Ryosuke Misawa, Atsuyoshi Mita, Luca Inverardi, Rodolfo Alejandro, Hirohito Ichii
    Pancreas 43(8) 1317-22 2014年11月  
    OBJECTIVES: The effects of glucocorticoid during culture on human islet cells have been controversial. Exendin-4 (EX) enhances the insulin secretion and significantly improves clinical outcomes in islet cell transplantation. In this study, we examined the effects of glucocorticoids and EX on human islet cells during pretransplant culture. METHODS: Methylprednisolone (MP) and/or EX were added to the standard culture medium for clinical islet cell transplantation. Islets were cultured for 24 hours with 3 different conditions (control, no additives; MP alone; and MP + EX). β-Cell fractional viability, cellular composition, multiple cytokine/chemokine production, multiple phosphorylation proteins, and glucose-induced insulin secretion were evaluated. RESULTS: Viable β-cell survival in MP and MP + EX group was significantly higher than in the control group. Exendin-4 prevented MP-induced reduction of insulin secretion. Methylprednisolone supplementation to the culture medium decreased cytokine and chemokine production. Moreover, extracellular signal-regulated kinase 1/2 phosphorylation was significantly increased by MP and MP + EX. CONCLUSIONS: Glucocorticoid supplementation into culture media significantly decreased the cytokine/chemokine production and increased the extracellular signal-regulated kinase 1/2 phosphorylation, resulting in the improvement of human β-cell survival. In addition, EX maintained the insulin secretion suppressed by MP. The supplementation of MP and EX together could be a useful strategy to create suitable human islets for transplantation.
  • 石黒 保直, 佐久間 康成, 笹沼 英紀, 藤原 岳人, 黒河内 顕, 三木 厚, 兼田 裕司, 森嶋 計, 佐田 尚宏, 安田 是和
    日本消化器外科学会雑誌 47(Suppl.2) 211-211 2014年10月  
  • 石岡 秀基, 石黒 保直, 森嶋 計, 三木 厚, 兼田 裕司, 黒河内 顕, 笹沼 英紀, 佐久間 康成, 佐田 尚宏, 安田 是和
    日本消化器外科学会雑誌 47(Suppl.2) 258-258 2014年10月  
  • 佐田 尚宏, 田口 昌延, 笠原 直哉, 森嶋 計, 兼田 裕司, 三木 厚, 石黒 保直, 黒河内 顕, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 清水 敦, 栗原 克己, 安田 是和
    胆と膵 35(臨増特大) 1125-1129 2014年10月  
  • Yukihiro Sanada, Naoya Yamada, Masanobu Taguchi, Kazue Morishima, Naoya Kasahara, Yuji Kaneda, Atsushi Miki, Yasunao Ishiguro, Akira Kurogochi, Kazuhiro Endo, Masaru Koizumi, Hideki Sasanuma, Takehito Fujiwara, Yasunaru Sakuma, Atsushi Shimizu, Masanobu Hyodo, Naohiro Sata, Yoshikazu Yasuda
    INTERNATIONAL SURGERY 99(4) 426-431 2014年7月  査読有り
  • 清水 敦, 佐田 尚宏, 森嶋 計, 兼田 裕司, 石黒 保直, 三木 厚, 黒河内 顕, 遠藤 和洋, 小泉 大, 笹沼 英紀, 佐久間 康成, 田中 昌宏, 安田 是和
    外科 76(7) 747-752 2014年7月  
  • T Shimizu, T Urahashi, Y Ihara, Y Kaneda, A Miki, Y Sanada, T Wakiya, N Okada, N Yamada, K Mizuta
    Transplantation proceedings 46(3) 999-1000 2014年4月  
    Anastomotic stricture of the choledochojejunostomy is a common complication after living donor liver transplantation. Most anastomotic strictures can be treated by percutaneous transhepatic cholangiodrainage and/or double balloon endoscopy. However, in severe cases and/or in small infants, neither of these is possible. Our new technique, cholangiography accompanied by cholangioscopy, enabled successful guidewire placement and balloon dilatation in cases with severe anastomotic stricture.
  • Yukihiro Sanada, Youichi Kawano, Atsushi Miki, Junko Aida, Ken-ichi Nakamura, Naotaka Shimomura, Naoshi Ishikawa, Tomio Arai, Yuta Hirata, Naoya Yamada, Noriki Okada, Taiichi Wakiya, Yoshiyuki Ihara, Taizen Urahashi, Yoshikazu Yasuda, Kaiyo Takubo, Koichi Mizuta
    Transplant International 27(4) 383-390 2014年4月  
  • A. Miki, Y. Sakuma, H. Sasanuma, Y. Kaneda, N. Sata, Y. Yasuda
    PANCREAS 42(8) 1368-1368 2013年11月  
  • Wataru Nishimura, Koki Eto, Atsushi Miki, Motohito Goto, Miho Kawaguchi, Takao Nammo, Haruhide Udagawa, Masaki Hiramoto, Yukiko Shimizu, Tadashi Okamura, Toshiyoshi Fujiwara, Yoshikazu Yasuda, Kazuki Yasuda
    Endocrinology 154(11) 4388-4395 2013年11月1日  査読有り
  • Ai Sadatomo, Koji Koinuma, Atsushi Miki, Hisanaga Horie, Yoshikazu Yasuda
    Gan to kagaku ryoho. Cancer & chemotherapy 40(7) 943-5 2013年7月  
    A 64-year-old man received mFOLFOX6+bevacizumab chemotherapy for metastatic lung cancer after rectal cancer resection( Stage IV). After 28 courses, he had an abdominal pain with fever, and computed tomography showed pelvic abscess with stercolith of appendix. He was diagnosed as acute appendicitis with intra-abdominal abscess, and emergency appendectomy with drainage was performed. Two days after the operation, he was suspected to have a sutural leakage as was suggested from the properties of his drainage, therefore re-operation was performed. A small hole of the ileum, about 2mm in diameter, was observed. The margin of the hole showed neither inflammatory nor neoplastic change, and a suturing closure of the hole was performed. The post-operative course was uneventful. Histopathological findings of the resected appendix suggested that the perforation was caused by necrosis of metastatic cancer cells penetrating the appendiceal wall. This is a case of a bevacizumab-related metachronous perforation that occurred in different gastrointestinal origins within a very short term.
  • 西村 渉, 衛藤 弘城, 三木 厚, 南茂 隆生, 川口 美穂, 宇田川 陽秀, 平本 正樹, 佐久間 康成, 安田 是和, 安田 和基
    糖尿病 56(Suppl.1) S-253 2013年4月  
  • A. Miki, N. Sata, Y. Sakuma, M. Taguchi, N. Kasahara, K. Morishima, Y. Kaneda, K. Endo, M. Koizumi, H. Sasanuma, A. Shimizu, M. Hyodo, A. T. Lefor, Y. Yasuda
    PANCREAS 41(8) 1386-1386 2012年11月  
  • 芝 順太郎, 齋藤 心, 三木 厚, 黒河内 顕, 太白 健一, 齋藤 晶, 宮倉 安幸, 堀江 久永, 安田 是和, 栗原 克己
    日本臨床外科学会雑誌 73(増刊) 675-675 2012年10月  
  • Atsushi Miki, Yasuyuki Miyakura, Yasunaru Sakuma, Hidetoshi Kumano, Hisanaga Horie, Naohiro Sata, Alan T Lefor, Yoshikazu Yasuda
    The American surgeon 78(9) E425-6 2012年9月  
  • Masaru Koizumi, Naohiro Sata, Masanobu Taguchi, Naoya Kasahara, Kazue Morishima, Yuji Kaneda, Atsushi Miki, Kunihiko Shimura, Hideki Sasanuma, Takehito Fujiwara, Makoto Ota, Atsushi Shimizu, Masanobu Hyodo, Alan T. Lefor, Yoshikazu Yasuda
    JOURNAL OF SURGICAL EDUCATION 69(5) 605-610 2012年9月  査読有り
  • Hidenori Takahashi, Phillip Ruiz, Camillo Ricordi, Victor Delacruz, Atsushi Miki, Atsuyoshi Mita, Ryosuke Misawa, Scott Barker, George W Burke, Andreas G Tzakis, Hirohito Ichii
    Cell transplantation 21(1) 113-25 2012年  
    There is abundant evidence that immune cells infiltrating into a transplanted organ play a critical role for destructive inflammatory or regulatory immune reactions. Quantitative in situ analysis (i.e., in tissue sections) of immune cells remains challenging due to a lack of objective methodology. Laser scanning cytometry (LSC) is an imaging-based methodology that performs quantitative measurements on fluorescently and/ or chromatically stained tissue or cellular specimens at a single-cell level. In this study, we have developed a novel objective method for analysis of immune cells, including Foxp3(+) T regulatory cells (Tregs), on formalin-fixed /paraffin-embedded (FFPE) transplant biopsy sections using iCys® Research Imaging Cytometer. The development of multiple immunofluorescent staining was established using FFPE human tonsil sample. The CD4/CD8 ratio and the population of Tregs among CD4(+) cells were analyzed using iCys and compared with the results from conventional flow cytometry analysis (FCM). Our multiple immunofluorescent staining techniques allow obtaining clear staining on FFPE sections. The CD4/CD8 ratio analyzed by iCys was concordant with those obtained by FCM. This method was also applicable for liver, small intestine, kidney, pancreas, and heart transplant biopsy sections and provide an objective quantification of Tregs within the grafts.
  • 藤原 岳人, 兼田 裕司, 森嶋 計, 三木 厚, 俵藤 正信, 太田 真, 清水 敦, 佐久間 康成, 眞田 幸弘, 脇屋 太一, 浦橋 泰然, 水田 耕一, 安田 是和
    日本臨床外科学会雑誌 72(増刊) 408-408 2011年10月  
  • 太田 真, 俵藤 正信, 藤原 岳人, 小泉 大, 三木 厚, 兼田 裕司, 黒河内 顕, 長瀬 通隆, 佐田 尚弘, 安田 是和
    日本肝胆膵外科学会・学術集会プログラム・抄録集 23回 357-357 2011年6月  
  • Toshiyuki Yamamoto, Atsuyoshi Mita, Camillo Ricordi, Shari Messinger, Atsushi Miki, Yasunaru Sakuma, Francesca Timoneri, Scott Barker, Alessia Fornoni, R Damaris Molano, Luca Inverardi, Antonello Pileggi, Hirohito Ichii
    Transplantation 89(11) 1328-35 2010年6月15日  
    OBJECTIVES: Recent studies demonstrated that prolactin (PRL) has beneficial effects on beta cells for islet transplantation. We examined the effect of human recombinant PRL (rhPRL) supplementation to the culture media to determine its potential use in the context of clinical islet transplantation. MATERIALS AND METHODS: Each human islet isolated from 14 deceased multiorgan donors was cultured in Miami modified media-1 supplemented with or without rhPRL (500 microg/L) for 48 hr. beta-Cell survival and proliferation (BrdU and Ki-67) were determined by laser scanning cytometry. The cytoprotective effects of rhPRL against noxious stimuli were assessed by flow cytometry (tetramethylrhodamine ethyl ester). Cytokine/chemokine and tissue factor productions were measured in vitro, and islet potency was assessed in vivo in diabetic immunodeficient mice. RESULTS: beta-Cell survival during culture was 37% higher in the rhPRL group than in control (P=0.029). rhPRL protected beta cells in vitro from cytokines, Nitric oxide donor, and H2O2. The exposure to rhPRL did not affect human beta-cell proliferation with our protocol. rhPRL treatment did not alter cytokine/chemokine and tissue factor production in vitro or affected human islet functionality in vivo: recipient mice achieved normoglycemia with a comparable tempo, whereas loss of graft function was observed in two of the seven mice in the control group and in none of the rhPRL group (p=n.s.). CONCLUSION: rhPRL supplementation to islet culture media improved human beta-cell-specific survival without altering islet quality. Addition of rhPRL to cultured islets may grant a more viable beta-cell mass in culture. The development of beta-cell cytoprotective strategies will be of assistance in improving islet transplantation outcomes.
  • Atsushi Miki, Ricordi Camillo, Yasunaru Sakuma, Ryosuke Misawa, Luca Inverardi, Antonello Pileggi, Naohiro Sata, Yoshikazu Yasuda, Hirohito Ichii
    AMERICAN JOURNAL OF TRANSPLANTATION 10 78-78 2010年1月  

MISC

 196
  • 青木裕一, 笹沼秀紀, 下平健太郎, 木村有希, 目黒由行, 田口昌延, 森嶋計, 三木厚, 兼田裕司, 池田恵理子, 池田恵理子, 菅野敦, 福嶋敬宜, 佐田尚弘
    膵臓(Web) 38(3) 2023年  
  • Yuichi Aoki, Hisashi Oshiro, Akihiko Yoshida, Kazue Morishima, Atsushi Miki, Hideki Sasanuma, Yasunaru Sakuma, Alan Kawarai Lefor, Naohiro Sata
    BMC gastroenterology 20(1) 105-105 2020年4月15日  
    BACKGROUND: Capicua transcriptional repressor (CIC) -rearranged sarcoma is characterized by small round cells, histologically similar to Ewing sarcoma. However, CIC-rearranged sarcoma has different clinical, histological, and immunohistochemical features from Ewing sarcoma. It is important to differentiate between these tumors. CASE PRESENTATION: The patient is a 44-year-old man with a duodenal tumor diagnosed in another hospital who presented with a history of melena. Laboratory studies showed anemia with a serum hemoglobin of 6.0 g/dL. He was hospitalized and gastrointestinal bleeding was controlled successfully with endoscopy. However, he suffered from appetite loss and vomiting and progression of anemia a few weeks after presentation. Upper gastrointestinal endoscopy showed a circumferential soft tumor in the second portion of the duodenum and the endoscope could not pass distally. Computed tomography scan showed a greater than 10 cm tumor in the duodenum, with compression of the inferior vena cava and infiltrating the ascending colon. A definitive pathologic diagnosis could not be established despite four biopsies from the tumor edge. Due to gastrointestinal obstruction and progression of anemia, a pylorus-preserving pancreaticoduodenectomy with partial resection of the inferior vena cava and right hemicolectomy was performed as a complete tumor resection. The tumor was diagnosed as a CIC-rearranged sarcoma, but 2 months postoperatively local recurrence and distant metastases to the liver and lung were found. The patient died 3 months after surgery. CONCLUSIONS: Although the only definitive treatment for CIC-rearranged sarcoma is surgical resection, the CIC-rearranged sarcoma is highly malignant with a poor prognosis even after radical resection. More research is needed to establish optimal treatment strategies.
  • 松宮美沙希, 猪瀬悟史, 田中保平, 高見真梨子, 崎尾亮太郎, 加賀谷丈紘, 太白健一, 宮崎千絵子, 田原真紀子, 三木厚, 鯉沼広治, 栗原克己, 金井信行
    日本臨床外科学会雑誌 81 2020年  
  • 吉田 淳, 笹沼 英紀, 片野 匠, 篠原 翔一, 森嶋 計, 三木 厚, 宮戸 英世, 遠藤 和洋, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    胆道 33(3) 581-581 2019年10月  
  • 篠原 翔一, 笹沼 英紀, 宮戸 英世, 森嶋 計, 三木 厚, 遠藤 和洋, 吉田 淳, 佐久間 康成, 北山 丈二, 佐田 尚宏
    胆道 33(3) 628-628 2019年10月  

共同研究・競争的資金等の研究課題

 8