研究者業績

佐藤 滋

サトウ シゲル  (Shigeru Sato)

基本情報

所属
自治医科大学 分子病態治療研究センター 循環病態・代謝学研究部 准教授
学位
博士(理学)(1995年3月 東北大学)

J-GLOBAL ID
200901051614996694
researchmap会員ID
1000273348

外部リンク

学歴

 2

論文

 39
  • Jumpei Terakawa, Vanida A Serna, Devi M Nair, Shigeru Sato, Kiyoshi Kawakami, Sally Radovick, Pascal Maire, Takeshi Kurita
    Cell death and differentiation 27(12) 3307-3320 2020年6月22日  査読有り
    During female mammal reproductive tract development, epithelial cells of the lower Müllerian duct are committed to become stratified squamous epithelium of the vagina and ectocervix, when the expression of ΔNp63 transcription factor is induced by mesenchymal cells. The absence of ΔNp63 expression leads to adenosis, the putative precursor of vaginal adenocarcinoma. Our previous studies with genetically engineered mouse models have established that fibroblast growth factor (FGF)/mitogen-activated protein kinase (MAPK), bone morphogenetic protein (BMP)/SMAD, and activin A/runt-related transcription factor 1 (RUNX1) signaling pathways are independently required for ΔNp63 expression in Müllerian duct epithelium (MDE). Here, we report that sine oculis homeobox homolog 1 (SIX1) plays a critical role in the activation of ΔNp63 locus in MDE as a downstream transcription factor of mesenchymal signals. In the developing mouse reproductive tract, SIX1 expression was restricted to MDE within the future cervix and vagina. SIX1 expression was totally absent in SMAD4 null MDE and was reduced in RUNX1 null and FGFR2 null MDE, indicating that SIX1 is under the control of vaginal mesenchymal factors: BMP4, activin A and FGF7/10. Furthermore, Six1, Runx1, and Smad4 gene-dose-dependently activated ΔNp63 expression in MDE within the vaginal fornix. Using a mouse model of diethylstilbestrol (DES)-associated vaginal adenosis, we found DES action through epithelial estrogen receptor α (ESR1) inhibits activation of ΔNp63 locus in MDE by transcriptionally repressing SIX1 and RUNX1 in the vaginal fornix.
  • Takahashi M, Tamura M, Sato S, Kawakami K
    Disease models & mechanisms 11(10) 2018年10月  査読有り
  • Reza MS, Kobiyama A, Yamada Y, Ikeda Y, Ikeda D, Mizusawa N, Ikeo K, Sato S, Ogata T, Jimbo M, Kudo T, Kaga S, Watanabe S, Naiki K, Kaga Y, Mineta K, Bajic V, Gojobori T, Watabe S
    Gene 665 185-191 2018年7月  査読有り
  • Sato S, Furuta Y, Kawakami K
    Developmental dynamics : an official publication of the American Association of Anatomists 247(1) 250-261 2018年1月  査読有り
  • Ikeda K, Takahashi M, Sato S, Igarashi H, Ishizuka T, Yawo H, Arata S, Southard-Smith EM, Kawakami K, Onimaru H
    PloS one 10(7) e0132475 2015年  査読有り

MISC

 42

講演・口頭発表等

 41

担当経験のある科目(授業)

 10

共同研究・競争的資金等の研究課題

 23