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  2. 崔 龍洙

崔 龍洙

サイ リュウシュ  (Longzhu Cui)

基本情報

所属
自治医科大学 医学部感染・免疫学講座　細菌学部門 教授
学位
(BLANK)
研究者番号
50306932
ORCID ID
 https://orcid.org/0000-0002-8909-3885
J-GLOBAL ID
200901096624649406
researchmap会員ID
1000264314
外部リンク

研究キーワード

 5

研究分野

 4

経歴

 9
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学歴

 2

委員歴

 8
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受賞

 4

論文

 117
  • 崔龍洙 Longzhu Cui
    CRISPR Medicine News 2024年12月18日  
  • Aye Mya Sithu Shein, Dhammika Leshan Wannigama, Cameron Hurst, Peter N. Monk, Mohan Amarasiri, Thidathip Wongsurawat, Piroon Jenjaroenpun, Phatthranit Phattharapornjaroen, William Graham Fox Ditcham, Puey Ounjai, Thammakorn Saethang, Naphat Chantaravisoot, Vishnu Nayak Badavath, Sirirat Luk-in, Sumanee Nilgate, Ubolrat Rirerm, Sukrit Srisakul, Naris Kueakulpattana, Matchima Laowansiri, S. M. Ali Hosseini Rad, Supaporn Wacharapluesadee, Apaporn Rodpan, Natharin Ngamwongsatit, Arsa Thammahong, Hitoshi Ishikawa, Robin James Storer, Asada Leelahavanichkul, Naveen Kumar Devanga Ragupathi, Annika Y. Classen, Talerngsak Kanjanabuch, Daniel Pletzer, Kazuhiko Miyanaga, Longzhu Cui, Hiroshi Hamamoto, Paul G. Higgins, Anthony Kicic, Tanittha Chatsuwan, Parichart Hongsing, Shuichi Abe
    Scientific Reports 2024年11月22日  
  • Aa Haeruman Azam, Kohei Kondo, Kotaro Chihara, Tomohiro Nakamura, Shinjiro Ojima, Wenhan Nie, Azumi Tamura, Wakana Yamashita, Yo Sugawara, Motoyuki Sugai, 崔龍洙 Longzhu Cui, Yoshimasa Takahashi, Koichi Watashi, Kotaro Kiga
    Nature Communications 2024年11月11日  
    <jats:title>Abstract</jats:title> <jats:p>Retrons are bacterial genetic elements that encode a reverse transcriptase and, in combination with toxic effector proteins, can serve as antiphage defense systems. However, the mechanisms of action of most retron effectors, and how phages evade retrons, are not well understood. Here, we show that some phages can evade retrons and other defense systems by producing specific tRNAs. We find that expression of retron-Eco7 effector proteins (PtuA and PtuB) leads to degradation of tRNA<jats:sup>Tyr</jats:sup> and abortive infection. The genomes of T5 phages that evade retron-Eco7 include a tRNA-rich region, including a highly expressed tRNA<jats:sup>Tyr</jats:sup> gene, which confers protection against retron-Eco7. Furthermore, we show that other phages (T1, T7) can use a similar strategy, expressing a tRNA<jats:sup>Lys</jats:sup>, to counteract a tRNA anticodon defense system (PrrC170).</jats:p>
  • Longzhu Cui, Kotaro Kiga, Kiran Kondabagil, Alicja Węgrzyn
    Scientific Reports 2024年10月17日  
  • Aye Mya Sithu Shein, Parichart Hongsing, Aisha Khatib, Phatthranit Phattharapornjaroen, Kazuhiko Miyanaga, Longzhu Cui, Kenji Shibuya, Mohan Amarasiri, Peter N. Monk, Anthony Kicic, Tanittha Chatsuwan, Paul G. Higgins, Shuichi Abe, Dhammika Leshan Wannigama
    npj Antimicrobials and Resistance 2024年10月10日  
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MISC

 164

書籍等出版物

 1

所属学協会

 7
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共同研究・競争的資金等の研究課題

 23
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産業財産権

 3
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