研究者業績

小澤敬也

オザワケイヤ (Keiya Ozawa)

基本情報

所属: 自治医科大学（JMU）教授

学位: 医学博士(東京大学)

J-GLOBAL ID: 200901030330125009
researchmap会員ID: 0000018135

研究キーワード

6

研究分野

1

ライフサイエンス / 血液、腫瘍内科学 /

経歴

72

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学歴

2

- 1977年

東京大学医学部医学科
- 1977年

University of Tokyo Faculty of Medicine

委員歴

7

2000年 - 2001年

国際実験血液学会 ISEH Standing Scientific Program Committee Member
1999年

日本癌学会評議員
1996年

がん分子標的治療研究会世話人
1994年

日本遺伝子治療学会幹事、評議員、プログラム委員
1994年

日本ウイルス学会将来計画委員会(将来構想検討委員会)委員

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受賞

2

MISC

501

Effective prevention of relapse following allogeneic bone marrow transplantation (BMT) with recombinant human glycosylated G-CSF-combined regimen in drug resistant acute myeloid leukemia. In, The Mechanism and New Approach on Drug Resistance of Can・・・

Elsevier Science Publishers B.V.,p.303-3l0,1993

Effective prevention of relapse following allogeneic bone <br /> marrow transplantation (BMT) with recombinant human <br /> glycosylated G-CSF-combined regimen in drug resistant <br /> acute myeloid leukemia. In, The Mechanism and New <br /> Approach on Drug Resistance of Cancer Cells.
Effect of interferon-α in patients with chronic myelogenous lenkemia in accelerated phase: Cytogenetic and molecular studies.

Jpn.J.Cancer Res.81:682-686.1990.
Direct binding of C-terminal region of pl30cas to SH2 and SH3 domains of Src kinase.

J.Biol.Chem.271:8959-8965,1996
Differentiation induction of human promyelocytic lenkemia cells by acyclic retinoid (polyprenoic acid).

Int.J.Hematol.59:9-15,1993.
Differentiation and proliferation of lenkemic progenitor cells.

Acta Haematol.Jpn.46:1559-1567,1983.
Development of selective amplifier genes for hematopoietic stem cell gene therapy.

Proceeding of the International Workshop "Stem Cell Biology and Cellular and Molecular Treatment", pp.135-140, 2000.
Development of acute lymphoblastic lenkemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: A novel transgenic model for human Ph1 positive leukemias.

Blood 91:2067-2075,1998.
Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells.

Blood 90:3884-3892,1997.
Deletion of Src homology 3 domain results in constitutive activation of Tec protein-tyrosine kinase.

Jpn.J.Cancer Res.87:1106-1110,1996.
DNA replication of parvovirus B 19 in a human erythroid leukemia cell line (JK-1) in vitro.

Arch.Virol.131:201-208,1993.
Combined therapy with interferonα and methotrexate for the treatment of chronic myelogenous leukemia. In, The Mechanism and New Approach on Drug Resistance of Cancer Cells.

Elsevier Science Publishers B.V.,p.279-282,1993.
Collection of sufficient number of peripheral blood stem cells in healthy volunteer donors mobilized by rhG-CSF for allogeneic transplantation

Bone Marrow Transplant.12(Suppl.2):22,1993.
Cloning and characterization of mouse tec promoter. Biochem. Biophys.

Res.Commun.223:422-426,1996.
Clinical and biological aspects of interferon-alpha in the treatment of chronic myelogenous leukemia.

Gann Monograph on Cancer Research40:145-154,1993 .
Chronic bone marrow failure due to persistent B19 parvovirus infection.

N.Engl.J.Med.317:287-294,1987.
Charged-to-alanine scanning mutagenesis of N-terminal half of adeno-associated virus type 2 Rep78 protein.

J.Virol.(in press)
Charged-to alanine scanning mutagenesis of the N-terminal half of adeno-associated virus type 2 Rep78 protein.

J. Virol.73: 2682-2693, 1999.
Characterization of transformed hematopoietic cells afier activated ras gene transfection. In, Myelodysplastic Syndromes: Advances in Research and Treatment.

Elsevier Science B.V.p.237-243,1995.
Characterization of capsid and noncapsid proteins of B19 parvovirus propagated in human erythroidbone marrow cell cultures.

J.Virol.61:2627-2630, 1987.
Characteristics of granulocyte-macrophage colony formation in patients with chronic myelomonocytic Leukemia

Stem Cells1:345-353,1981
Changes in hematopoiesis-supporting ability of C3HIOTl/2 mouse embryo fibroblasts during differentiation.

Blood 81:1184-l192,1993.
Case report: Alternation therapy with antileukemic agents and recombinant human granulocyte colony-stimulating factor for RAEB in transformation.

Am.J.Med.Sci.303:316-318,1992.
Case report. Hemophagocytosis as a para-neoplastic syndrome in NK cell leukemia.

Int.J.Hematol.64:135-142,1996.
Biological activity of C-terminus modified version of human granulocyte colony-stimulating factor.

Biochem.Biophys.Res.Commun.(in press)
Binding of membrane-anchored macrophage colony-stimulating factor (M-CSF) to its receptor mediates specific adhesion between stromal cells and M-CSF receptor-bearing hematopoietic cells.

Blood 82:2634-2640,1993.
Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors.

Hum. Gene Ther.9:2527-2535,1998.
Basic studies toward hematopoietic stem cell gene therapy. In, Cell Therapy (ed. by Ikeda, Y., Hata, J., Koyasu, S., Kawakami, Y., Hattori, Y.)

Springer-Verlag, Tokyo, p.159-169, 2000.
B19 parvovirus replicates in erythroid leukemia cells in vitro.

J.Infect.Dis.160:548-549,1989.
Autologous peripheral blood stem cell transplantation for adults with B-lineage acute lymphoblastic leukemia: a pilot study.

Leukemia Lymphoma 38: 103-111, 2000.
Autologous bone marrow transplantation for patients with advanced chronic myelogenous leukemia.

Int.J.Hematol.66:493-503,1997.
Apoptosis-mediated regulation of recombinant human granulocyte eolony-stimulating factor production by genetically engineered fibroblasts.

Gene Ther.5:923-929,1998.
Adult T-cell lenkemia developing during immunosuppressive treatment in a renal transplant recipient.

Am.J.Hematol.41:292-294,1992.
Adhesion of NFS-60 myeloid leukemia cells to MC3T3-G2/PA6 stromal cells induces granulocyte colony-stimulating factor production.

Blood 84:415-420,l994.
Adeno-associated virus vector-mediated bcl-2 gene transfer into post-ischemic gerbil brain in vivo: prospects for gene therapy of ischemia-induced neuronal death.

Gene Ther. 7: 1244-1249, 2000.
Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome.

J.Virol.71:7951-7959,1997.
Adeno-associated virus (AAV) vectors and gene therapy of Parkinson's disease. In, Progress in Gene Therapy-Basic and Clinical Frontiers. (ed. by Bertolotti, R., Parvez, S. H., and Nagatsu, T.)

VSP BV, Natherlands, pp.289-306, 2000.
Acquisition of IL-3-independence in FDC-P2 cells after transfection with the activated c-H-rasgene using a bovine papillomavirus-based plasmid vector.

Blood 80:3198-3204,1992.
Acceleration of neutrophilic granulocyte recovery in bone recombinant human granulocyte colony marrow transplanted patients by administration.

Lancetii:38-39, 1988.
A synergistic increase in transplantable peripheral blood stem cells in mice by co-administration of recombinant human interleukin 6 and recombinant human granulocyte colony-stimulating factor.

Transplantation59:1596-1600,1995.
A selective amplifier gene for tamoxifen-inducible expansion of hematopoietic cells.

J. Gene Med. 1:236-244, 1999.
A possible correlation between the type of bcr-abl hybrid messenger RNA and platelet count in Philadelphia-positive chronic myelogenous leukemia.

Blood 78:3125-3127,1991
A novel strategy for the tumor angiogenesis-targeted gene therapy: Generation of angiostatin endogenous plasminogen by protease gene transfer.

Cancer Gene Ther. 7: 589-596, 2000.
A novel selective amplifier gene for hematopoietic stem cell gene therapy.

Cancer Res.Ther.Contr.7:27-31,1998.
A novel gene (drad-J) expressed in hematopoiesis-supporting stromal cell lines, ST2, PA6 and A54 preadipocytes:Use of mRNA differential display

Stem Cells15:334-339,1997.
A novel dicistronic AAV (adeno-associated virus) vector using a short IRES (internal ribosome entry site) segment derived from hepatitis C virus genome.

Gene 200: 157-162, 1997.
A new method for permanent preparations of hemopoietic cells in methylcellulose medium.

Hematol.10:145-150,1982.
A new apoptotic pathway for the complement factor B-derived fragment Bbeta.

J. Cell. Physiol. 185: 280-292, 2000.
A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction.

Blood 96: 941-949, 2000.
A case of myelodysplastic syndrome (refractory anemia) transforming into acute leukemia with monosomy 7 afier administration of granulocyte colony-stimulating factor. In, Myelodysplastic Syndromes: Advances in Research and Treatment.

Elsevier Science B.V, p.357-359, 1995.
A case of bilateral heel ulcers associated with hydroxyurea therapy for chronic myelogenous leukemia.

Jpn. J. Clin. Oncol. 30: 159-162, 2000.

所属学協会

40

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共同研究・競争的資金等の研究課題

6

遺伝子治療

ミレニアム・プロジェクト
遺伝子治療

厚生労働科学研究費補助金
遺伝子治療

科学研究費補助金
Gene therapy

Millennium Project
Gene therapy

Health and Labour Sciences Research Grants

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