研究者業績

小澤敬也

オザワケイヤ (Keiya Ozawa)

基本情報

所属: 自治医科大学（JMU）教授

学位: 医学博士(東京大学)

J-GLOBAL ID: 200901030330125009
researchmap会員ID: 0000018135

研究キーワード

6

研究分野

1

ライフサイエンス / 血液、腫瘍内科学 /

経歴

72

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学歴

2

- 1977年

東京大学医学部医学科
- 1977年

University of Tokyo Faculty of Medicine

委員歴

7

2000年 - 2001年

国際実験血液学会 ISEH Standing Scientific Program Committee Member
1999年

日本癌学会評議員
1996年

がん分子標的治療研究会世話人
1994年

日本遺伝子治療学会幹事、評議員、プログラム委員
1994年

日本ウイルス学会将来計画委員会(将来構想検討委員会)委員

もっとみる

受賞

2

MISC

536

Implantation of genetically manipulated fibroblasts into mice as anti-tumor alpha-interferon therapy

Cancer Res. 50: 5102-5106, 1990.
Implantation of genetically manipulated fibroblasts into mice as a model of cytokine supplementation gene therapy using human G-CSF and IFN-alpha cDNAS. In, Molecular Approaches to the Study and Treatment of Human Diseases.

Elsevier Science Publishers B.V.,p.419-428,1992.
Implantation of fibroblasts transfected with human granulocyte colony-stimulating factor (G-CSF)cDNA into mice as a model of cytokine supplement gene therapy.

Blood 74:1274-1280,1989.
Identification of PU. I and Spl as essential transcription factors for the promoter activity of mouse tec gene.

Biochem.Biophys.Res.Commun.234:376-381,1997.
Human granulocyte colony formation in serum-free cultures stimulated with purified recombinant granulocyte colony- stimulating factor.

Exp. Hematol.18:883-887,1990.
Highly-regulated expression of adeno-associated virus large Rep proteins in stable 293 cell lines using the Cre-loxP switching system.

J. Gen. Virol. 80: 2477-2480, 1999.
Hemopoietic precursor cells in erythroleukemia

Stem Cells1:224-232,1981
Hematopoietic stem cell gene therapy: a current overview.

Int. J. Hematol. 69: 227-233, 1999.
Hematopoiesis-supporting ability of a differentiation-inducible stromal cell line of mouse embryo fibroblasts.

Bone Marrow Transplant.12(Suppl.2):29,1993.
HRX gene rearrangement in secondary acute lymphoblastic leukemia.

Leukemia and Lymphoma17:391-399,1995.
HRX gene rearrangement in acute lymphoblastic leukemia after adjuvant chemotherapy of breast cancer.

Blood82:3220-3221,1993.
Green fluorescent protein as a selectable marker of retrovirally transduced hematopoietic progenitors.

Stem Cells 17: 226-232, 1999.
Granulocyte colony-stimulating factor stimulates human mature neutrophilic granulocytes to pre interferon-alpha.

Blood75:17-19,1990.
Gene transfer into rat renal cells using adeno-associated virus vectors.

Am. J. Nephrol. 20: 242-247, 2000.
Gene therapy of a rodent model of Parkinson's disease using adeno-associated virus (AAV) vectors. In, Progress in Alzheimer's and Parkinson's Disease

Plenum Publishing Co.p.647-652,1998.
Gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors.

J. Neural Transm. [suppl] 58: 181-191, 2000.
Functional mapping of the genome of the B19 (human) parvovirus by in vitro translation after negative hybrid selection.

J.Virol.62:2508-2511,1988.
Filamented pseudomonas aeruginosa and a markedly high level of endotoxin in cerebrospinal fluid.

J. Infect. 41: 114-115, 2000.
Fatal GVHD demonstrating an involvement of respiratory muscle following donor leukocyte transfusion (DLT).

Bone Marrow Transplant.19:737-740,1997.
Fas and mutant estrogen receptor chimeric gene: a novel suicide vector for tamoxifen-inducible apoptosis.

Jpn.J.Cancer Res.89:741-747,1998.
Expression profiles of I and sialosyl-1 antigens on blood cells: the sialosyl-1 antigen is expressed along the monocytic differentiation.

Leukemia Res. 22: 1029-1036, 1998.
Expression of granulocyte and granulocyte-macrophage colony-stimulating factors by human non-hematopoietic tumor cells.

Growth Factors3:325-331.1990.
Essential thrombocythemia transformed to acute myelogenous leukemia with t(3;17)(p24;q12), del(5)(q13q34) after treatment with carboquone and hydroxyurea.

J. Clin. Oncol. 30: 310-312, 2000.
Enhancement of human T lymphocyte colony formation by 12-0- tetradecanoylphorbol-13-acetate(TPA)

Exp.Hematol.11:1014-10211983.
Engraftment syndrome after autologous peripheral blood stem cell transplantation with high numbers of peripheral blood stem cells followed by granulocyte colony-stimulating factor administration.

Bone Marrow Transplant. 25: 228-229, 2000.
Endogenously generated nitric oxide by nitric-oxide synthase gene transfer inhibits cellular proliferation.

J. Phamacol. Exp. Therapeut. 292: 387-393, 2000.
Elimination of small cell lung cancer cells in vitro from human bone marrow by a monoclonal antibody.

Cancer Res.45:1930-1933,1985.
Elevated expression of DNA polymerase P gene in glioma cell lines with acquired resistance to 1-(4-amin0-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea.

Biochem. Biophys.Res. Commun. 227: 558-563, 1996.
Efficient production of adeno-associated virus vectors using split-type helper plasmids.

Jpn. J. Cancer Res. 90: 476-483, 1999.
Effects of recombinant interferons on the clonogenic growth of leukemic cells and normal hemopoietic Progenitors

Int.J.Cell Cloning 304-312,1985.
Effects of prostaglandin E on the proliferation and differentiation of leukemic progenitor cnonlymphocytic leukemia.

Int.J.Cell CloningI:440-450,1983.
Effects of myeloid cell growth factors on alkaline phosphatase, myeloperoxidase, defensin and granulocyte colony-stimulating t'actor receptor mRNA expression in hematopoietic cells of normal indiciduals and myeloid disorders.

Brit.J Haematol.92:9-22,1996.
Effects of lithium on the growth of hematopoietic progenitors in vitro.

Folia Psychiatrica et Neurologica Jpn.37:413,1983
Effects of interleukin-6(IL-6)on hematopoiesis in bone marrow transplanted mice.

Transplantation 47:738-740,1989.
Effects of 12-tetradecanoylphorbol-13-acetate on the proliferation and differentiation of normal leukemic myeloid progenitor cells.

Cancer Res.43:2306-2310,1983.
Effective prevention of relapse following allogeneic bone marrow transplantation (BMT) with recombinant human glycosylated G-CSF-combined regimen in drug resistant acute myeloid leukemia. In, The Mechanism and New Approach on Drug Resistance of Can・・・

Elsevier Science Publishers B.V.,p.303-3l0,1993

Effective prevention of relapse following allogeneic bone <br /> marrow transplantation (BMT) with recombinant human <br /> glycosylated G-CSF-combined regimen in drug resistant <br /> acute myeloid leukemia. In, The Mechanism and New <br /> Approach on Drug Resistance of Cancer Cells.
Effect of interferon-α in patients with chronic myelogenous lenkemia in accelerated phase: Cytogenetic and molecular studies.

Jpn.J.Cancer Res.81:682-686.1990.
Direct binding of C-terminal region of pl30cas to SH2 and SH3 domains of Src kinase.

J.Biol.Chem.271:8959-8965,1996
Differentiation induction of human promyelocytic lenkemia cells by acyclic retinoid (polyprenoic acid).

Int.J.Hematol.59:9-15,1993.
Differentiation and proliferation of lenkemic progenitor cells.

Acta Haematol.Jpn.46:1559-1567,1983.
Development of selective amplifier genes for hematopoietic stem cell gene therapy.

Proceeding of the International Workshop "Stem Cell Biology and Cellular and Molecular Treatment", pp.135-140, 2000.
Development of acute lymphoblastic lenkemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: A novel transgenic model for human Ph1 positive leukemias.

Blood 91:2067-2075,1998.
Development of a novel selective amplifier gene for controllable expansion of transduced hematopoietic cells.

Blood 90:3884-3892,1997.
Deletion of Src homology 3 domain results in constitutive activation of Tec protein-tyrosine kinase.

Jpn.J.Cancer Res.87:1106-1110,1996.
DNA replication of parvovirus B 19 in a human erythroid leukemia cell line (JK-1) in vitro.

Arch.Virol.131:201-208,1993.
Combined therapy with interferonα and methotrexate for the treatment of chronic myelogenous leukemia. In, The Mechanism and New Approach on Drug Resistance of Cancer Cells.

Elsevier Science Publishers B.V.,p.279-282,1993.
Collection of sufficient number of peripheral blood stem cells in healthy volunteer donors mobilized by rhG-CSF for allogeneic transplantation

Bone Marrow Transplant.12(Suppl.2):22,1993.
Cloning and characterization of mouse tec promoter. Biochem. Biophys.

Res.Commun.223:422-426,1996.
Clinical and biological aspects of interferon-alpha in the treatment of chronic myelogenous leukemia.

Gann Monograph on Cancer Research40:145-154,1993 .
Chronic bone marrow failure due to persistent B19 parvovirus infection.

N.Engl.J.Med.317:287-294,1987.

所属学協会

40

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共同研究・競争的資金等の研究課題

6

遺伝子治療

ミレニアム・プロジェクト
遺伝子治療

厚生労働科学研究費補助金
遺伝子治療

科学研究費補助金
Gene therapy

Millennium Project
Gene therapy

Health and Labour Sciences Research Grants

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