研究者業績

小澤敬也

オザワケイヤ (Keiya Ozawa)

基本情報

所属: 自治医科大学（JMU）教授

学位: 医学博士(東京大学)

J-GLOBAL ID: 200901030330125009
researchmap会員ID: 0000018135

研究キーワード

6

研究分野

1

ライフサイエンス / 血液、腫瘍内科学 /

経歴

72

もっとみる

学歴

2

- 1977年

東京大学医学部医学科
- 1977年

University of Tokyo Faculty of Medicine

委員歴

7

2000年 - 2001年

国際実験血液学会 ISEH Standing Scientific Program Committee Member
1999年

日本癌学会評議員
1996年

がん分子標的治療研究会世話人
1994年

日本遺伝子治療学会幹事、評議員、プログラム委員
1994年

日本ウイルス学会将来計画委員会(将来構想検討委員会)委員

もっとみる

受賞

2

MISC

501

Vrral vectors for gene therapy.

Proeeedings of Bio Japan'96 Symposium.p.139-146,1996.
Unusual tumor formation in the tongue of an acute myelocytic leukemia patient: report of a case.

Oral Med. Pathol. 5: 53-56, 2000.
Ultrastructural cytochemistry of human erythroblasts in culture.

Microscopy15:5-6,1982
Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes.

Mol. Cell. Biol. 19:2754-2762, 1999.
Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor: A preliminary report.

Am.J.Med.86:178-182,1989.
Treatment of myelodysplastic syndrome using recombinant human erythropoietin in combination with short course administration of granulocyte colony-stimulating factor. In, Myelodysplastic Syndromes: Advances in Research and Treatment.

Elsevier Science B.V.p.337-341,1995
Translational regulation of B19 parvovirus capsid protein production by multiple upstream AUG triplets.

J.Biol.Chem.263:I0922-10926,1988.
Transduction of LacZ gene into leukemia cells using viral vectors ofretrovirus and adenovirus.

Leukemia9(Suppl.l):S64-S65,1995.
The use of heterologous promoters for adeno-associated virus (AAV) protein expression in AAV vector production.

Microbiol.Immunol.42:177-185,1998.
The gene encoding the nonstructural protein of B19 (human) parvovirus may be lethal in transf ected cells.

J.Virol.62:2884-2889,1988.
The effect of hydrocortisone on human granulopoiesis in vitro with cytochemical analysis of colonies.

Exp. Hematol.11:114-121,1983.
The alloantigen-specific immunosuppressive activity of estradiol-chlorarnbucil conjugate (KM2210)and its beneficial effect on allogeneic bone marrow transplantation in mice.

Transplantation54:676-681,1992.
Tec protein-tyrosine kinase is involved in the thrombopoietin/c-Mpl signaling pathway.

Exp.Hematol.25:211-216,1997.
Tec protein-tyrosine kinase is an effector molecule ofLyn protein-tyrosine kinase.

FASEBJ.10:637-642,1996.
Tec protein tyrosine kinase is involved in the signaling mechanism of granulocyte colony-stimulating factor receptor.

Cell Growth&Diff.7:1135-1139,1996.
Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription,

Blood 91:1496-1507,1998.
Sustained c-kit expression in a human erythrolenkemia cell line (HEL) afier megakaryocytic differentiation induced by 12- 0 tetradecanoylphorbol-13-acetate(TPA).

Leukemia Res.17:1079-1082,1993.
Susceptibility of human erythropoietic cells to B19 parvovirus in vitro increases with differentiation.

Blood75:603-610,1990.
Studies on nude mice bearing human CSF-producing tumor. III. Colony type of granulocyte-macrophage

Stem Cells 2:335-343,1982.
Studies of the B19 parivovirus in bone marrow cell culture. In, Parvoviruses and Human Disease

CRC Press,Boca Raton,p.117-132,31988.
Strategies for gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors.

Biogenic Amines 15: 21-37, 1999.
Strategies for gene therapy of Parkinson's disease using adeno-associated virus (AAV) vectors.

Biogenic Amines(in press)
Spontaneous bacterial peritonitis due to clostridium perfringens in a patient with liver cirrhosisand pure red cell aplasia.

Gastroenterol.Jpn.27:662-667.1992.
Smouldering leukemia Cytochemical changes of lenkemic cells associated with karyotypic evolutio in transition to overt leukemia.

Acta Haematol.Jpn. 46: 90-99, 1983.
Several new approaches to improvement of ot-interferon therapy in chronic myelogenous leukemia.

Eur.J.Cancer27(Suppl.4):S21-S25,1991.
Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay.

Blood 73:I17-122,1989.
Retrovirus-mediated gene transfer of human pyruvate kinase (PK) CDNA into murine hematopoietic cells: Implications for gene therapy of human PK deficiency.

Blood 83:2305-2310,1994.
Replication of the B19 parvovirus in human bone marrow cell cultures.

Science233:883-886,1986.
Regulatory production of granulocyte colony-stimulating factor (G-CSF) by stromal cells. In,Hematopoietic Growth Factors: Molecular Biology to Clinical Applications of rG-CSF.

Excerpta Medica,p.55-81,1991
Regulation of recombinant human granulocyte colony-stimulating factor production using herpes simplex virus I thymidine kinase gene.

Biochem.Biophys.Res.Commun.200:1245-1251,1994.
Recombinant immune interferon inhibits leukemic cell growth by a monocyte-macrophage-mediated mechanism.

Exp.Hematol,13:597-602,1985.
Recombinant human glycosylated granulocyte colony-stimulating factor (rhG-CSF)-combined regimen for allogeneic bone marrow transplantation in refractory acute myeloid leukemia.

Bone Marrow Transplant.13:239-245,1994.
Radiation sensitivity of leukemic progenitor cells in acute nonlymphocytic leukemia.

Cancer Res.43:2339-2341.1983 .
Quality of life in adult patients after stem cell transplantation.

Int. J. Hematol. 71: 283-289, 2000.
Pure red cell aplasia caused by parvovirus B 19 infection in a renal transplant recipient.

Eur.J.Haematol.54:68-69,1995.
Productive infection by B19 parvovirus of human erythroid bone marrow cells in vitro.

Blood70:384-391,1987.
Production of human granulocyte colony stimulating factor by various kinds of stromal cells in vitro detected by enzyme immunoassay and in situhybridizatio

Stem Cells12:416-423,1994.
Problems in the pathogenesis of aplastic anemia. In. Progress in Bone Marrow Transplantation.

Alan R.Liss,Inc.,p.3-12,1987.
Potential application of dominant negative retinoic acid receptor genes for ex vivo expansion of hematopoietic stem cells.

Gene Ther. Mol. Biol. 3: 293-300, 1999.
Potential application of dominant negative retinoic acid receptor genes for ex vivo expansion of hematopoietic stem cells.

Gene Ther.Mol.Biol.(in press)
Possible pathophysiological roles of G-CSF in myelodysplastic syndromes (MDS): A case report, In.Myelodysplastic Syndrome and Cytokines.

Elsevier Science Publishers B.V.,p.161-166,1991 .
Possible correlation between fusion pattern of BCR/ABL mRNA and clinical response to cx-interferonin chronic myelogenous leukemia.

Leukemia 6:948-951,1992.
Phenotypic conversion of T-lineage lymphoblasts in the lymph node to myeloblasts in the bone marrow during relapse after allogeneic bone marrow transplantation.

Int. J. Hematol. 72: 253-254, 2000.
Pharmacokinetics studies of intravenous glycosylated recombinant human granulocyte colony-stimulating factor in various hematological disorders:

Int.J.Hematol.66:57-67,1997.
Pathophysiological roles of G-CSF. In. Proceedings of the Ist International Congress on Vitamins and Biofactors in Life Science in Kobe,1991

Center for Academic Publications Japan,p.345-348,1992.
Novel transcription map for the B19(human) pathogenic parvovirus.

J.Virol.61:2395-2406,1987.
NH2-terminal pentapeptide of endothelial interleukin 8 is responsible for the induction of apoptosis in leukemic cells and has an antitumor effect in vivo.

Cancer Res. 59: 5651-5655, 1999.
N(G)-monomethyl-L-arginine inhibits erythropoietin gene expression by stimulating GATA-2.

Blood 96: 1716-1722, 2000.
Molecular breakpoints and platelet counts in chronic myeloid leukemia.

Blood 80:556-557,1992.
Modulation of normal myelopoiesisin vitro by retinoic acid. Biochem.

Biophys. Res.Commun,123:128-132,1984.

所属学協会

40

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共同研究・競争的資金等の研究課題

6

遺伝子治療

ミレニアム・プロジェクト
遺伝子治療

厚生労働科学研究費補助金
遺伝子治療

科学研究費補助金
Gene therapy

Millennium Project
Gene therapy

Health and Labour Sciences Research Grants

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