研究者業績

小澤敬也

オザワケイヤ (Keiya Ozawa)

基本情報

所属: 自治医科大学（JMU）教授

学位: 医学博士(東京大学)

J-GLOBAL ID: 200901030330125009
researchmap会員ID: 0000018135

研究キーワード

6

研究分野

1

ライフサイエンス / 血液、腫瘍内科学 /

経歴

72

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学歴

2

- 1977年

東京大学医学部医学科
- 1977年

University of Tokyo Faculty of Medicine

委員歴

7

2000年 - 2001年

国際実験血液学会 ISEH Standing Scientific Program Committee Member
1999年

日本癌学会評議員
1996年

がん分子標的治療研究会世話人
1994年

日本遺伝子治療学会幹事、評議員、プログラム委員
1994年

日本ウイルス学会将来計画委員会(将来構想検討委員会)委員

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受賞

2

MISC

501

Chronic bone marrow failure due to persistent B19 parvovirus infection.

N.Engl.J.Med.317:287-294,1987.
Charged-to-alanine scanning mutagenesis of N-terminal half of adeno-associated virus type 2 Rep78 protein.

J.Virol.(in press)
Charged-to alanine scanning mutagenesis of the N-terminal half of adeno-associated virus type 2 Rep78 protein.

J. Virol.73: 2682-2693, 1999.
Characterization of transformed hematopoietic cells afier activated ras gene transfection. In, Myelodysplastic Syndromes: Advances in Research and Treatment.

Elsevier Science B.V.p.237-243,1995.
Characterization of the kinase activity essential for tyrosine phosphorylation of pl30cas in fibroblasts.

Oncogene14:1419-1426,1997.
Characterization of capsid and noncapsid proteins of B19 parvovirus propagated in human erythroidbone marrow cell cultures.

J.Virol.61:2627-2630, 1987.
Characteristics of granulocyte-macrophage colony formation in patients with chronic myelomonocytic Leukemia

Stem Cells1:345-353,1981
Changes in hematopoiesis-supporting ability of C3HIOTl/2 mouse embryo fibroblasts during differentiation.

Blood 81:1184-l192,1993.
Case report: Alternation therapy with antileukemic agents and recombinant human granulocyte colony-stimulating factor for RAEB in transformation.

Am.J.Med.Sci.303:316-318,1992.
Case report. Hemophagocytosis as a para-neoplastic syndrome in NK cell leukemia.

Int.J.Hematol.64:135-142,1996.
Biological activity of C-terminus modified version of human granulocyte colony-stimulating factor.

Biochem.Biophys.Res.Commun.(in press)
Binding of membrane-anchored macrophage colony-stimulating factor (M-CSF) to its receptor mediates specific adhesion between stromal cells and M-CSF receptor-bearing hematopoietic cells.

Blood 82:2634-2640,1993.
Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors.

Hum. Gene Ther.9:2527-2535,1998.
Basic studies toward hematopoietic stem cell gene therapy. In, Cell Therapy (ed. by Ikeda, Y., Hata, J., Koyasu, S., Kawakami, Y., Hattori, Y.)

Springer-Verlag, Tokyo, p.159-169, 2000.
B19 parvovirus replicates in erythroid leukemia cells in vitro.

J.Infect.Dis.160:548-549,1989.
Autologous peripheral blood stem cell transplantation for adults with B-lineage acute lymphoblastic leukemia: a pilot study.

Leukemia Lymphoma 38: 103-111, 2000.
Autologous bone marrow transplantation for patients with advanced chronic myelogenous leukemia.

Int.J.Hematol.66:493-503,1997.
Apoptosis-mediated regulation of recombinant human granulocyte eolony-stimulating factor production by genetically engineered fibroblasts.

Gene Ther.5:923-929,1998.
Adult T-cell lenkemia developing during immunosuppressive treatment in a renal transplant recipient.

Am.J.Hematol.41:292-294,1992.
Adhesion of NFS-60 myeloid leukemia cells to MC3T3-G2/PA6 stromal cells induces granulocyte colony-stimulating factor production.

Blood 84:415-420,l994.
Adeno-associated virus vector-mediated bcl-2 gene transfer into post-ischemic gerbil brain in vivo: prospects for gene therapy of ischemia-induced neuronal death.

Gene Ther. 7: 1244-1249, 2000.
Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome.

J.Virol.71:7951-7959,1997.
Adeno-associated virus (AAV) vectors and gene therapy of Parkinson's disease. In, Progress in Gene Therapy-Basic and Clinical Frontiers. (ed. by Bertolotti, R., Parvez, S. H., and Nagatsu, T.)

VSP BV, Natherlands, pp.289-306, 2000.
Acquisition of IL-3-independence in FDC-P2 cells after transfection with the activated c-H-rasgene using a bovine papillomavirus-based plasmid vector.

Blood 80:3198-3204,1992.
Acceleration of neutrophilic granulocyte recovery in bone recombinant human granulocyte colony marrow transplanted patients by administration.

Lancetii:38-39, 1988.
A synergistic increase in transplantable peripheral blood stem cells in mice by co-administration of recombinant human interleukin 6 and recombinant human granulocyte colony-stimulating factor.

Transplantation59:1596-1600,1995.
A selective amplifier gene for tamoxifen-inducible expansion of hematopoietic cells.

J. Gene Med. 1:236-244, 1999.
A possible correlation between the type of bcr-abl hybrid messenger RNA and platelet count in Philadelphia-positive chronic myelogenous leukemia.

Blood 78:3125-3127,1991
A novel strategy for the tumor angiogenesis-targeted gene therapy: Generation of angiostatin endogenous plasminogen by protease gene transfer.

Cancer Gene Ther. 7: 589-596, 2000.
A novel selective amplifier gene for hematopoietic stem cell gene therapy.

Cancer Res.Ther.Contr.7:27-31,1998.
A novel gene (drad-J) expressed in hematopoiesis-supporting stromal cell lines, ST2, PA6 and A54 preadipocytes:Use of mRNA differential display

Stem Cells15:334-339,1997.
A novel dicistronic AAV (adeno-associated virus) vector using a short IRES (internal ribosome entry site) segment derived from hepatitis C virus genome.

Gene 200: 157-162, 1997.
A new method for permanent preparations of hemopoietic cells in methylcellulose medium.

Hematol.10:145-150,1982.
A new apoptotic pathway for the complement factor B-derived fragment Bbeta.

J. Cell. Physiol. 185: 280-292, 2000.
A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction.

Blood 96: 941-949, 2000.
A case of myelodysplastic syndrome (refractory anemia) transforming into acute leukemia with monosomy 7 afier administration of granulocyte colony-stimulating factor. In, Myelodysplastic Syndromes: Advances in Research and Treatment.

Elsevier Science B.V, p.357-359, 1995.
A case of bilateral heel ulcers associated with hydroxyurea therapy for chronic myelogenous leukemia.

Jpn. J. Clin. Oncol. 30: 159-162, 2000.
A Stu I polymorphism in the human granulocyte colony-stimulating factor gene.

Nucl.Acid Res.17:7544,1989.
A functional role of mitogen-activated protein kinases, Erk1 and Erk2, in the differentiation of a human leukemia cell line, UT-7/GM: A possible key factor for cell fate determination toward erythroid and megakaryocytic lineages.

Int. J. Hematol. 73 : 78-83, 2001.
g-Rays enhance rAAV-mediated transgene expression and cytocidal effect of AAV-HSVtk / ganciclovir on cancer cells.

Cancer Gene Ther. 8 : 99-106, 2001
Forkhead family transcription factor FKHRL1 is expressed in human megakaryocytes and regulates cell cycling as a downstream molecule of TPO signaling.

J. Biol. Chem. 276 : 15082-15089, 2001.
Morphological and physiological restorations of hereditary form of dilated cardiomyopathy by somatic gene therapy. Biochem. Biophys.

Res. Commun. 284 : 431-435, 2001.
Antitumor effect of beta2-microglobulin in leukemic cell-bearing mice via apoptosis-inducing activity : activation of caspase-3 and nuclear factor-kappaB.

Cancer Res. 61 : 4414-4417, 2001.
CD13 is the resistance mechanism for endothelial interleukin-8 inducing apoptosis. In, Cell-Surface Aminopeptidases : Basic and Clinical Aspects. (ed. by Mizutani, S.and Turner, A.J.)

Elsevier Science B.V., p. 177-184, 2001.
Adeno-associated virus-mediated transfer of endothelial nitric oxide synthase gene reduces vasoconstrictive response.

Exp. Clin. Cardiol. 6 : 50-55, 2001.
A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus. Hum.

Gene Ther. 12 : 1047-1061, 2001.
Targeted integration of foreign dna into a defined locus on chromosome 19 in K562 cells using MV-derived components.

Int. J. Hematol. 73 : 469-475, 2001.
Adeno-associated virus-mediated transfer of endothelial nitric oxide synthase gene inhibits protein synthesis of rat ventricular cardiomyocytes. Cardiovas.

Drug Ther. 15 : 19-24, 2001.
Colon cancer with meningeal carcinomatosis and myelodysplastic syndrome in a patient who underwent intensive chemotherapy for acute myelogenous leukemia : a case report.

Jpn. J. Clin. Oncol. 31: 221-225, 2001.
beta₂-Microglobulin identified as an apoptosis-inducing factor and its characterization.

Blood 94: 2744-2753, 1999.

所属学協会

40

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共同研究・競争的資金等の研究課題

6

遺伝子治療

ミレニアム・プロジェクト
遺伝子治療

厚生労働科学研究費補助金
遺伝子治療

科学研究費補助金
Gene therapy

Millennium Project
Gene therapy

Health and Labour Sciences Research Grants

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